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Hair growth potential of Salvia plebeia extract and its associated mechanisms.
Pharm Biol. 2020 Dec; 58(1):400-409.PB

Abstract

Context:

Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.

Objective:

To investigate the hair growth potential of SP extract by using human dermal papilla cells (hDPCs) and C57BL/6 mice.Materials and methods: The entire SP plant sample was ground into powder and extracted with 99.9% methyl alcohol. Various concentrations of SP extract were added to hDPCs to evaluate the proliferation, migration, and factors related to hair growth and cycling. Effect of topical SP administration on hair regrowth was tested in vivo in male C57BL/6 mice for 21 days.

Results:

SP extract significantly increased the proliferation of cultured hDPCs at doses of 15.6 and 31.3 μg/mL compared to control group by 123% and 132%, respectively. Expression of hepatocyte growth factor increased while the level of TGF-β1 and SMAD2/3 decreased when treated with SP extract. At the molecular level, the extract activated Wnt/β-catenin signalling by raising β-catenin and phospho-GSK3β expression. SP extract also exerted anti-apoptotic and proliferative effects in hDPCs by increasing the Bcl-2/Bax ratio and activating cell proliferation-related proteins, ERK and Akt. Finally, the extract caused an induction of the anagen phase leading to significantly enhanced hair growth in treated male mice.Discussion and conclusion: Our results indicate that SP extract has the capacity to activate hDPCs into a proliferative state to promote hair growth. Further research is necessary to determine the bioactive components and their mechanisms of action responsible for SP-related hair growth effect.

Authors+Show Affiliations

Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi, Korea.Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi, Korea.Center for Cardiovascular Research, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.Center for Cardiovascular Research, John A Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.Department of Food and Nutrition, College of Biotechnology and Natural Resources, Chung-Ang University, Anseong, Gyeonggi, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32420784

Citation

Jin, Guang-Ri, et al. "Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms." Pharmaceutical Biology, vol. 58, no. 1, 2020, pp. 400-409.
Jin GR, Zhang YL, Yap J, et al. Hair growth potential of Salvia plebeia extract and its associated mechanisms. Pharm Biol. 2020;58(1):400-409.
Jin, G. R., Zhang, Y. L., Yap, J., Boisvert, W. A., & Lee, B. H. (2020). Hair growth potential of Salvia plebeia extract and its associated mechanisms. Pharmaceutical Biology, 58(1), 400-409. https://doi.org/10.1080/13880209.2020.1759654
Jin GR, et al. Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms. Pharm Biol. 2020;58(1):400-409. PubMed PMID: 32420784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hair growth potential of Salvia plebeia extract and its associated mechanisms. AU - Jin,Guang-Ri, AU - Zhang,Yi-Lin, AU - Yap,Jonathan, AU - Boisvert,William A, AU - Lee,Bog-Hieu, PY - 2020/5/19/entrez PY - 2020/5/19/pubmed PY - 2021/3/13/medline KW - Akt KW - Bax KW - Bcl-2 KW - C57BL/6 mice KW - ERK KW - GSK3β KW - Human dermal papilla cells KW - anti-apoptotic KW - hair regrowth KW - β-catenin SP - 400 EP - 409 JF - Pharmaceutical biology JO - Pharm Biol VL - 58 IS - 1 N2 - Context: Although Salvia plebeia (SP) R. Brown (Labiatae) is known to possess various biological activities, the effects of SP on hair growth have not been elucidated.Objective: To investigate the hair growth potential of SP extract by using human dermal papilla cells (hDPCs) and C57BL/6 mice.Materials and methods: The entire SP plant sample was ground into powder and extracted with 99.9% methyl alcohol. Various concentrations of SP extract were added to hDPCs to evaluate the proliferation, migration, and factors related to hair growth and cycling. Effect of topical SP administration on hair regrowth was tested in vivo in male C57BL/6 mice for 21 days.Results: SP extract significantly increased the proliferation of cultured hDPCs at doses of 15.6 and 31.3 μg/mL compared to control group by 123% and 132%, respectively. Expression of hepatocyte growth factor increased while the level of TGF-β1 and SMAD2/3 decreased when treated with SP extract. At the molecular level, the extract activated Wnt/β-catenin signalling by raising β-catenin and phospho-GSK3β expression. SP extract also exerted anti-apoptotic and proliferative effects in hDPCs by increasing the Bcl-2/Bax ratio and activating cell proliferation-related proteins, ERK and Akt. Finally, the extract caused an induction of the anagen phase leading to significantly enhanced hair growth in treated male mice.Discussion and conclusion: Our results indicate that SP extract has the capacity to activate hDPCs into a proliferative state to promote hair growth. Further research is necessary to determine the bioactive components and their mechanisms of action responsible for SP-related hair growth effect. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/32420784/Hair_growth_potential_of_Salvia_plebeia_extract_and_its_associated_mechanisms_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2020.1759654 DB - PRIME DP - Unbound Medicine ER -