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Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection.
Am J Physiol Endocrinol Metab. 2020 06 01; 318(6):E878-E880.AJ

Abstract

The viral pandemic of the coronavirus disease 2019 (COVID-19), generated by a novel mutated severe acute respiratory syndrome coronavirus (SARS-CoV-2), has become a serious worldwide public health emergency, evolving exponentially. While the main organ targeted in this disease is the lungs, other vital organs, such as the heart and kidney, may be implicated. The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). The ACE2 is also involved in testicular male regulation of steroidogenesis and spermatogenesis. As the SARS-CoV-2 may have the potential to infect the testis via ACE2 and adversely affect male reproductive system, it is essential to commence with targeted studies to learn from the current pandemic, with the possibility of preemptive intervention, depending on the findings and time course of the continuing pandemic.

Authors+Show Affiliations

Reproductive Medicine, Department of Obstetrics and Gynecology, Baruch Padeh Medical Center, Poriya, Israel. Azrieili Faculty of Medicine in Galilee, Bar-Ilan University, Safed, Israel.Department of Physiology, Rappaport Faculty of Medicine, Technion, Haifa, Israel. Laboratory Medicine, Rambam Health Care Campus, Haifa, Israel.Azrieili Faculty of Medicine in Galilee, Bar-Ilan University, Safed, Israel.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32421367

Citation

Younis, Johnny S., et al. "Is There an Impact of the COVID-19 Pandemic On Male Fertility? the ACE2 Connection." American Journal of Physiology. Endocrinology and Metabolism, vol. 318, no. 6, 2020, pp. E878-E880.
Younis JS, Abassi Z, Skorecki K. Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. Am J Physiol Endocrinol Metab. 2020;318(6):E878-E880.
Younis, J. S., Abassi, Z., & Skorecki, K. (2020). Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. American Journal of Physiology. Endocrinology and Metabolism, 318(6), E878-E880. https://doi.org/10.1152/ajpendo.00183.2020
Younis JS, Abassi Z, Skorecki K. Is There an Impact of the COVID-19 Pandemic On Male Fertility? the ACE2 Connection. Am J Physiol Endocrinol Metab. 2020 06 1;318(6):E878-E880. PubMed PMID: 32421367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is there an impact of the COVID-19 pandemic on male fertility? The ACE2 connection. AU - Younis,Johnny S, AU - Abassi,Zaid, AU - Skorecki,Karl, Y1 - 2020/05/18/ PY - 2020/5/19/pubmed PY - 2020/6/9/medline PY - 2020/5/19/entrez SP - E878 EP - E880 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 318 IS - 6 N2 - The viral pandemic of the coronavirus disease 2019 (COVID-19), generated by a novel mutated severe acute respiratory syndrome coronavirus (SARS-CoV-2), has become a serious worldwide public health emergency, evolving exponentially. While the main organ targeted in this disease is the lungs, other vital organs, such as the heart and kidney, may be implicated. The main host receptor of the SARS-CoV-2 is angiotensin converting enzyme 2 (ACE2), a major component of the renin-angiotensin-aldosterone system (RAAS). The ACE2 is also involved in testicular male regulation of steroidogenesis and spermatogenesis. As the SARS-CoV-2 may have the potential to infect the testis via ACE2 and adversely affect male reproductive system, it is essential to commence with targeted studies to learn from the current pandemic, with the possibility of preemptive intervention, depending on the findings and time course of the continuing pandemic. SN - 1522-1555 UR - https://www.unboundmedicine.com/medline/citation/32421367/Is_there_an_impact_of_the_COVID_19_pandemic_on_male_fertility_The_ACE2_connection_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00183.2020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=www.ncbi.nlm.nih.gov DB - PRIME DP - Unbound Medicine ER -