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The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris.
J Cosmet Dermatol. 2020 May 18 [Online ahead of print]JC

Abstract

BACKGROUND

Epidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70%-100% of patients in a dose-dependent manner. Acneiform folliculitis is considered to be caused by an inflammatory process due to follicular hyperkeratosis and subsequently a set of changes both in epidermis and hair follicles as a result of epidermal growth factor receptor (EGFR) blockade. Both acne vulgaris and acneiform folliculitis due to EGFRIs show similar changes in the pilosebaceous unit. Furthermore, in both groups of patients, topical application of recombinant human epidermal growth factor (EGF) has been reported to improve the disease.

AIMS

In this study, it was aimed to investigate the role of EGF and EGFR amount, expression, and EGFR gene polymorphisms in the etiopathogenesis of acne vulgaris.

PATIENTS/METHODS

156 acne vulgaris patients, within 18-25 years of age, who had 15 or more inflammatory acne lesions on dermatologic evaluation were included in this study. The absence of any known systemic or genetic disease or cancer and any systemic or topical treatment for the last 1 month were prerequisites. In the control group, 154 volunteers in the same age range who were examined at the outpatient clinic with diagnoses of melanocytic nevus, ephelid, cherry angioma, and callus and who had no more than 3 inflammatory acne lesions were recruited. The amounts of EGF and EGFR were determined by sandwich ELISA, expressions of EGF and EGFR by reverse transcriptase polymerase chain reaction; EGFR polymorphisms were examined by restriction enzyme digestion, Sanger, and high-resolution melting methods.

RESULTS

The patient and control groups were compared in terms of EGFR gene polymorphisms in addition to the amount and expressions of EGF and EGFR. The amount of EGF in the serum was found to be significantly higher in the acne group. (P = .0012). There was no significant difference in other parameters studied.

CONCLUSION

The results of our study showed a significant increase in the amount of EGF in the acne group. Though EGF may be incriminated in the etiopathogenesis of AV, the most likely explanation about its role may be controlling inflammation from the very first stage.

Authors+Show Affiliations

Department of Dermatology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Turkey.Department of Dermatology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Turkey.Department of Medical Biology, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Turkey.Department of Biophysics, Acibadem Mehmet Ali Aydınlar University, School of Medicine, Istanbul, Turkey.Labgen Genetic Diagnostic Center, Acibadem Healthcare Services, Footnote: Biruni University, School of Medicine, Department of Medical Biology, Istanbul, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32421896

Citation

Aydingoz, Ikbal Esen, et al. "The Investigation of the Amounts and Expressions of Epidermal Growth Factor, Epidermal Growth Factor Receptor, and Epidermal Growth Factor Receptor Gene Polymorphisms in Acne Vulgaris." Journal of Cosmetic Dermatology, 2020.
Aydingoz IE, Tukenmez Demirci G, Agirbasli D, et al. The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris. J Cosmet Dermatol. 2020.
Aydingoz, I. E., Tukenmez Demirci, G., Agirbasli, D., Oz-Arslan, D., & Yenmis, G. (2020). The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris. Journal of Cosmetic Dermatology. https://doi.org/10.1111/jocd.13498
Aydingoz IE, et al. The Investigation of the Amounts and Expressions of Epidermal Growth Factor, Epidermal Growth Factor Receptor, and Epidermal Growth Factor Receptor Gene Polymorphisms in Acne Vulgaris. J Cosmet Dermatol. 2020 May 18; PubMed PMID: 32421896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor, and epidermal growth factor receptor gene polymorphisms in acne vulgaris. AU - Aydingoz,Ikbal Esen, AU - Tukenmez Demirci,Gulsen, AU - Agirbasli,Deniz, AU - Oz-Arslan,Devrim, AU - Yenmis,Guven, Y1 - 2020/05/18/ PY - 2020/01/23/received PY - 2020/03/23/revised PY - 2020/05/13/accepted PY - 2020/5/19/pubmed PY - 2020/5/19/medline PY - 2020/5/19/entrez KW - acne vulgaris KW - epidermal growth factor KW - epidermal growth factor receptor KW - etiology KW - gene expression JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol N2 - BACKGROUND: Epidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70%-100% of patients in a dose-dependent manner. Acneiform folliculitis is considered to be caused by an inflammatory process due to follicular hyperkeratosis and subsequently a set of changes both in epidermis and hair follicles as a result of epidermal growth factor receptor (EGFR) blockade. Both acne vulgaris and acneiform folliculitis due to EGFRIs show similar changes in the pilosebaceous unit. Furthermore, in both groups of patients, topical application of recombinant human epidermal growth factor (EGF) has been reported to improve the disease. AIMS: In this study, it was aimed to investigate the role of EGF and EGFR amount, expression, and EGFR gene polymorphisms in the etiopathogenesis of acne vulgaris. PATIENTS/METHODS: 156 acne vulgaris patients, within 18-25 years of age, who had 15 or more inflammatory acne lesions on dermatologic evaluation were included in this study. The absence of any known systemic or genetic disease or cancer and any systemic or topical treatment for the last 1 month were prerequisites. In the control group, 154 volunteers in the same age range who were examined at the outpatient clinic with diagnoses of melanocytic nevus, ephelid, cherry angioma, and callus and who had no more than 3 inflammatory acne lesions were recruited. The amounts of EGF and EGFR were determined by sandwich ELISA, expressions of EGF and EGFR by reverse transcriptase polymerase chain reaction; EGFR polymorphisms were examined by restriction enzyme digestion, Sanger, and high-resolution melting methods. RESULTS: The patient and control groups were compared in terms of EGFR gene polymorphisms in addition to the amount and expressions of EGF and EGFR. The amount of EGF in the serum was found to be significantly higher in the acne group. (P = .0012). There was no significant difference in other parameters studied. CONCLUSION: The results of our study showed a significant increase in the amount of EGF in the acne group. Though EGF may be incriminated in the etiopathogenesis of AV, the most likely explanation about its role may be controlling inflammation from the very first stage. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/32421896/The_investigation_of_the_amounts_and_expressions_of_epidermal_growth_factor,_epidermal_growth_factor_receptor,_and_epidermal_growth_factor_receptor_gene_polymorphisms_in_acne_vulgaris L2 - https://doi.org/10.1111/jocd.13498 DB - PRIME DP - Unbound Medicine ER -
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