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Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses.
Otolaryngol Head Neck Surg. 2020 07; 163(1):156-161.OH

Abstract

Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medicine's PubMed/MEDLINE database to query for articles describing COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, and other coronaviruses, with any mention of smell, taste, or other chemosensory or sinonasal dysfunction. Aggregate analysis demonstrated an incidence of 49.6% (n = 497 of 1002; 95% CI, 46.5%-52.7%), 47.9% (n = 480 of 1002; 95% CI, 44.8%-51.0%), and 17.9% (n = 880 of 4909; 95% CI, 16.9%-19.0%) for smell loss, taste loss, and smell or taste loss, respectively, in patients infected with SARS-CoV-2. Additionally, there were significantly higher incidences of runny nose/rhinorrhea/rhinitis and nasal congestion/obstruction/blockage in other coronaviruses as compared with SARS-CoV-2 (P < .001). Understanding these less well-characterized symptoms may help develop measures for estimating early markers of disease prevalence and/or resolution. Level of evidence: 4.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.Department of Otolaryngology-Head and Neck Surgery, University of California, Irvine, California, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32423285

Citation

Lehrich, Brandon M., et al. "Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 163, no. 1, 2020, pp. 156-161.
Lehrich BM, Goshtasbi K, Raad RA, et al. Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses. Otolaryngol Head Neck Surg. 2020;163(1):156-161.
Lehrich, B. M., Goshtasbi, K., Raad, R. A., Ganti, A., Papagiannopoulos, P., Tajudeen, B. A., & Kuan, E. C. (2020). Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 163(1), 156-161. https://doi.org/10.1177/0194599820929278
Lehrich BM, et al. Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses. Otolaryngol Head Neck Surg. 2020;163(1):156-161. PubMed PMID: 32423285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aggregate Prevalence of Chemosensory and Sinonasal Dysfunction in SARS-CoV-2 and Related Coronaviruses. AU - Lehrich,Brandon M, AU - Goshtasbi,Khodayar, AU - Raad,Richard A, AU - Ganti,Ashwin, AU - Papagiannopoulos,Peter, AU - Tajudeen,Bobby A, AU - Kuan,Edward C, Y1 - 2020/05/19/ PY - 2020/5/20/pubmed PY - 2020/7/16/medline PY - 2020/5/20/entrez KW - COVID-19 KW - coronavirus KW - olfaction KW - sinonasal outcomes KW - smell loss KW - taste loss SP - 156 EP - 161 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 163 IS - 1 N2 - Much of the published literature regarding the novel coronavirus disease 2019 (COVID-19) constitutes lower respiratory system symptomatology, while there exists a paucity of data describing the complicated sequelae of the upper respiratory system, including chemosensory and/or sinonasal dysfunction. This study utilized the National Library of Medicine's PubMed/MEDLINE database to query for articles describing COVID-19, SARS-CoV-2, SARS-CoV-1, MERS-CoV, and other coronaviruses, with any mention of smell, taste, or other chemosensory or sinonasal dysfunction. Aggregate analysis demonstrated an incidence of 49.6% (n = 497 of 1002; 95% CI, 46.5%-52.7%), 47.9% (n = 480 of 1002; 95% CI, 44.8%-51.0%), and 17.9% (n = 880 of 4909; 95% CI, 16.9%-19.0%) for smell loss, taste loss, and smell or taste loss, respectively, in patients infected with SARS-CoV-2. Additionally, there were significantly higher incidences of runny nose/rhinorrhea/rhinitis and nasal congestion/obstruction/blockage in other coronaviruses as compared with SARS-CoV-2 (P < .001). Understanding these less well-characterized symptoms may help develop measures for estimating early markers of disease prevalence and/or resolution. Level of evidence: 4. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/32423285/Aggregate_Prevalence_of_Chemosensory_and_Sinonasal_Dysfunction_in_SARS_CoV_2_and_Related_Coronaviruses_ L2 - https://journals.sagepub.com/doi/10.1177/0194599820929278?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -