Tags

Type your tag names separated by a space and hit enter

Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019.
Eye (Lond). 2020 Jul; 34(7):1220-1223.E

Abstract

OBJECTIVES

Since there are few reports on the ocular involvement of coronavirus disease 2019 (COVID-19) patients, this study aimed to assess the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in the tears of patients with COVID-19.

METHODS

In this prospective case series, nasopharyngeal and tear sampling of 43 patients with severe COVID-19 were performed. The quantitative reverse transcription polymerase chain reaction (RT-PCR) was conducted to detect SARS-CoV-2. Ocular and systemic signs and symptoms were recorded from their medical history.

RESULTS

The mean age of patients was 56 ± 13 years. The average disease time from initiation of symptoms was 3.27 days, range: 1-7 days. Forty-one patients (95.3%) had fever at the time of sampling. Only one patient had conjunctivitis. Thirty (69.8%) nasopharyngeal and three (7%) tear samples were positive for SARS-CoV-2. The result of tear sample was positive in the patient with conjunctivitis. All patients with positive tear RT-PCR results had positive nasopharyngeal RT-PCR results.

CONCLUSIONS

Ocular manifestation was rare in this series of severe COVID-19 patients, however, 7% of the patients had viral RNA in their conjunctival secretions. Therefore, possibility of ocular transmission should be considered even in the absence of ocular manifestations.

Authors+Show Affiliations

Ophthalmic Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Ophthalmology, Torfeh Medical Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Ophthalmic Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. amir_arab_91@yahoo.com. Department of Ophthalmology, Torfeh Medical Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. amir_arab_91@yahoo.com.Ophthalmic Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Department of Ophthalmology, Torfeh Medical Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Ophthalmic Epidemiology Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32424329

Citation

Karimi, Saeed, et al. "Detection of Severe Acute Respiratory Syndrome Coronavirus-2 in the Tears of Patients With Coronavirus Disease 2019." Eye (London, England), vol. 34, no. 7, 2020, pp. 1220-1223.
Karimi S, Arabi A, Shahraki T, et al. Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. Eye (Lond). 2020;34(7):1220-1223.
Karimi, S., Arabi, A., Shahraki, T., & Safi, S. (2020). Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. Eye (London, England), 34(7), 1220-1223. https://doi.org/10.1038/s41433-020-0965-2
Karimi S, et al. Detection of Severe Acute Respiratory Syndrome Coronavirus-2 in the Tears of Patients With Coronavirus Disease 2019. Eye (Lond). 2020;34(7):1220-1223. PubMed PMID: 32424329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of severe acute respiratory syndrome Coronavirus-2 in the tears of patients with Coronavirus disease 2019. AU - Karimi,Saeed, AU - Arabi,Amir, AU - Shahraki,Toktam, AU - Safi,Sare, Y1 - 2020/05/18/ PY - 2020/04/17/received PY - 2020/05/06/accepted PY - 2020/05/01/revised PY - 2020/5/20/pubmed PY - 2020/7/4/medline PY - 2020/5/20/entrez SP - 1220 EP - 1223 JF - Eye (London, England) JO - Eye (Lond) VL - 34 IS - 7 N2 - OBJECTIVES: Since there are few reports on the ocular involvement of coronavirus disease 2019 (COVID-19) patients, this study aimed to assess the presence of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) in the tears of patients with COVID-19. METHODS: In this prospective case series, nasopharyngeal and tear sampling of 43 patients with severe COVID-19 were performed. The quantitative reverse transcription polymerase chain reaction (RT-PCR) was conducted to detect SARS-CoV-2. Ocular and systemic signs and symptoms were recorded from their medical history. RESULTS: The mean age of patients was 56 ± 13 years. The average disease time from initiation of symptoms was 3.27 days, range: 1-7 days. Forty-one patients (95.3%) had fever at the time of sampling. Only one patient had conjunctivitis. Thirty (69.8%) nasopharyngeal and three (7%) tear samples were positive for SARS-CoV-2. The result of tear sample was positive in the patient with conjunctivitis. All patients with positive tear RT-PCR results had positive nasopharyngeal RT-PCR results. CONCLUSIONS: Ocular manifestation was rare in this series of severe COVID-19 patients, however, 7% of the patients had viral RNA in their conjunctival secretions. Therefore, possibility of ocular transmission should be considered even in the absence of ocular manifestations. SN - 1476-5454 UR - https://www.unboundmedicine.com/medline/citation/32424329/Detection_of_severe_acute_respiratory_syndrome_Coronavirus_2_in_the_tears_of_patients_with_Coronavirus_disease_2019_ L2 - http://dx.doi.org/10.1038/s41433-020-0965-2 DB - PRIME DP - Unbound Medicine ER -