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Neurologic complications of COVID-19.
Am J Emerg Med. 2020 07; 38(7):1549.e3-1549.e7.AJ

Abstract

BACKGROUND

Much of the focus regarding the global pandemic of coronavirus disease of 2019 (COVID-19) has been on the cardiovascular, pulmonary, and hematologic complications. However, neurologic complications have arisen as an increasingly recognized area of morbidity and mortality.

OBJECTIVE

This brief report summarizes the neurologic complications associated with COVID-19 with an emphasis on the emergency medicine clinician.

DISCUSSION

COVID-19 has infected over 3.5 million people and killed over 240,000 people worldwide. While pulmonary complications are profound, the neurologic system is also significantly impacted, with complications including acute cerebrovascular events, encephalitis, Guillain-Barré syndrome, acute necrotizing hemorrhagic encephalopathy, and hemophagocytic lymphohistiocytosis. Additionally, patients on immunosuppressive medications for pre-existing neurologic issues are at an increased risk for complications with COVID-19 infection, and many of the currently proposed COVID-19 therapies can interact with these medications.

CONCLUSIONS

When caring for COVID-19 patients, emergency medicine clinicians should be aware of the neurologic complications from COVID-19.

Authors+Show Affiliations

Department of Emergency Medicine, Brooke Army Medical Center, San Antonio, TX, United States of America.Department of Emergency Medicine, Brooke Army Medical Center, San Antonio, TX, United States of America. Electronic address: Brit.long@yahoo.com.Department of Emergency Medicine, Rush University Medical Center, Chicago, IL, United States of America.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32425321

Citation

Bridwell, Rachel, et al. "Neurologic Complications of COVID-19." The American Journal of Emergency Medicine, vol. 38, no. 7, 2020, pp. 1549.e3-1549.e7.
Bridwell R, Long B, Gottlieb M. Neurologic complications of COVID-19. Am J Emerg Med. 2020;38(7):1549.e3-1549.e7.
Bridwell, R., Long, B., & Gottlieb, M. (2020). Neurologic complications of COVID-19. The American Journal of Emergency Medicine, 38(7), e3-e7. https://doi.org/10.1016/j.ajem.2020.05.024
Bridwell R, Long B, Gottlieb M. Neurologic Complications of COVID-19. Am J Emerg Med. 2020;38(7):1549.e3-1549.e7. PubMed PMID: 32425321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurologic complications of COVID-19. AU - Bridwell,Rachel, AU - Long,Brit, AU - Gottlieb,Michael, Y1 - 2020/05/16/ PY - 2020/05/08/received PY - 2020/05/10/accepted PY - 2020/5/20/pubmed PY - 2020/7/17/medline PY - 2020/5/20/entrez KW - COVID-19 KW - Cerebrovascular disease KW - Coronavirus KW - Encephalopathy KW - HLH KW - Infectious disease KW - Neurologic SP - 1549.e3 EP - 1549.e7 JF - The American journal of emergency medicine JO - Am J Emerg Med VL - 38 IS - 7 N2 - BACKGROUND: Much of the focus regarding the global pandemic of coronavirus disease of 2019 (COVID-19) has been on the cardiovascular, pulmonary, and hematologic complications. However, neurologic complications have arisen as an increasingly recognized area of morbidity and mortality. OBJECTIVE: This brief report summarizes the neurologic complications associated with COVID-19 with an emphasis on the emergency medicine clinician. DISCUSSION: COVID-19 has infected over 3.5 million people and killed over 240,000 people worldwide. While pulmonary complications are profound, the neurologic system is also significantly impacted, with complications including acute cerebrovascular events, encephalitis, Guillain-Barré syndrome, acute necrotizing hemorrhagic encephalopathy, and hemophagocytic lymphohistiocytosis. Additionally, patients on immunosuppressive medications for pre-existing neurologic issues are at an increased risk for complications with COVID-19 infection, and many of the currently proposed COVID-19 therapies can interact with these medications. CONCLUSIONS: When caring for COVID-19 patients, emergency medicine clinicians should be aware of the neurologic complications from COVID-19. SN - 1532-8171 UR - https://www.unboundmedicine.com/medline/citation/32425321/Neurologic_complications_of_COVID_19_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-6757(20)30364-8 DB - PRIME DP - Unbound Medicine ER -