Tags

Type your tag names separated by a space and hit enter

Relationship between tRNA-derived fragments and human cancers.
Int J Cancer. 2020 May 19 [Online ahead of print]IJ

Abstract

tRNA-derived fragments, a class of small noncoding RNAs (sncRNAs), have been identified in numerous studies in recent years. tRNA-derived fragments are classified into two main groups, including tRNA halves (tiRNAs) and tRNA-derived small RNA fragments (tRFs), according to different cleavage positions of the precursor or mature tRNAs. Instead of random tRNA degradation debris, a growing body of evidence has shown that tRNA-derived fragments are precise products of specific tRNA modifications and play important roles in biological activities, such as regulating protein translation, affecting gene expression, and altering immune signaling. Recently, the relations between tRNA-derived fragments and the occurrence of human diseases, especially cancers, have generated wide interest. It has been demonstrated that tRNA-derived fragments are involved in cancer cell proliferation, metastasis, progression and survival. In this review, we will describe the biogenesis of tRNA-derived fragments, the distinct expression and function of tRNA-derived fragments in the development of cancers, and their emerging roles as diagnostic and prognostic biomarkers and precise targets of future treatments.

Authors+Show Affiliations

Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Nanjing Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Personalized Cancer Medicine, Nanjing Medical University, Nanjing, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32427348

Citation

Zeng, Tianyu, et al. "Relationship Between tRNA-derived Fragments and Human Cancers." International Journal of Cancer, 2020.
Zeng T, Hua Y, Sun C, et al. Relationship between tRNA-derived fragments and human cancers. Int J Cancer. 2020.
Zeng, T., Hua, Y., Sun, C., Zhang, Y., Yang, F., Yang, M., Yang, Y., Li, J., Huang, X., Wu, H., Fu, Z., Li, W., & Yin, Y. (2020). Relationship between tRNA-derived fragments and human cancers. International Journal of Cancer. https://doi.org/10.1002/ijc.33107
Zeng T, et al. Relationship Between tRNA-derived Fragments and Human Cancers. Int J Cancer. 2020 May 19; PubMed PMID: 32427348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between tRNA-derived fragments and human cancers. AU - Zeng,Tianyu, AU - Hua,Yijia, AU - Sun,Chunxiao, AU - Zhang,Yuchen, AU - Yang,Fan, AU - Yang,Mengzhu, AU - Yang,Yiqi, AU - Li,Jun, AU - Huang,Xiang, AU - Wu,Hao, AU - Fu,Ziyi, AU - Li,Wei, AU - Yin,Yongmei, Y1 - 2020/05/19/ PY - 2020/01/02/received PY - 2020/04/14/revised PY - 2020/05/11/accepted PY - 2020/5/20/pubmed PY - 2020/5/20/medline PY - 2020/5/20/entrez KW - biomarker KW - cancer progression KW - cancer treatment KW - chemoresistance KW - tRNA-derived fragments JF - International journal of cancer JO - Int. J. Cancer N2 - tRNA-derived fragments, a class of small noncoding RNAs (sncRNAs), have been identified in numerous studies in recent years. tRNA-derived fragments are classified into two main groups, including tRNA halves (tiRNAs) and tRNA-derived small RNA fragments (tRFs), according to different cleavage positions of the precursor or mature tRNAs. Instead of random tRNA degradation debris, a growing body of evidence has shown that tRNA-derived fragments are precise products of specific tRNA modifications and play important roles in biological activities, such as regulating protein translation, affecting gene expression, and altering immune signaling. Recently, the relations between tRNA-derived fragments and the occurrence of human diseases, especially cancers, have generated wide interest. It has been demonstrated that tRNA-derived fragments are involved in cancer cell proliferation, metastasis, progression and survival. In this review, we will describe the biogenesis of tRNA-derived fragments, the distinct expression and function of tRNA-derived fragments in the development of cancers, and their emerging roles as diagnostic and prognostic biomarkers and precise targets of future treatments. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/32427348/Relationship_between_tRNA_derived_fragments_and_human_cancers_ L2 - https://doi.org/10.1002/ijc.33107 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.