Tags

Type your tag names separated by a space and hit enter

Small-for-gestational age placentas associate with an increased risk of adverse outcomes in pregnancies complicated by either type I or type II pre-gestational diabetes mellitus.
J Matern Fetal Neonatal Med. 2020 May 19 [Online ahead of print]JM

Abstract

Introduction: One-fifth of pregnancies with pre-gestational diabetes mellitus (pre-DM) yield placentas <10th percentile small for gestational age (SGA), compared to a non-diabetic population. We hypothesized that SGA placentas of women with pre-DM, whether type I (T1DM) or type II (T2DM), exhibit distinct histopathological changes and pregnancy outcomes compared to pre-DM pregnancies with an AGA placenta.

Methods:

We conducted a retrospective, cohort study of placentas from pregnant women enrolled in the Diabetes in Pregnancy Program at Brown University between 2003 and 2011, by comparing pre-DM patients with SGA placentas to pre-DM patients with AGA placental weights.

Results:

The SGA placenta groups were associated with an increased risk for adverse clinical outcomes, compared to AGA placentas in pregnancies complicated by either T1DM or T2DM. Compared to their AGA pre-DM counterparts, T1DM, SGA placentas show increased peri-villous fibrin/fibrinoid deposition, thrombosis in fetal blood vessels, and meconium staining. Moreover, the histopathology of SGA placentas from T2DM is characterized by decidual vasculopathy, accelerated villous maturity, and erythroblastosis, compared to T2DM AGA placentas. The contrasting placental pathologies between the two pre-DM SGA phenotypes evolved independent of patient demographics and were unrelated to indicators of the glycemic control present at early gestational ages.Discussion: A sub-population of pre-DM women with either T1DM or T2DM diabetes that have an SGA placenta are at increased risk for adverse clinical outcomes in pregnancy, compared to pre-DM women with AGA placental weights.

Authors+Show Affiliations

Women and Infants Hospital of Rhode Island, RI, USA. Alpert Medical School of Brown University, RI, USA. Phoenix Perinatal Associates, Phoenix, AZ, USA.Women and Infants Hospital of Rhode Island, RI, USA.Penn State College of Medicine, Hershey, PA, USA.Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO, USA.Women and Infants Hospital of Rhode Island, RI, USA. Alpert Medical School of Brown University, RI, USA. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32429723

Citation

Starikov, Roman, et al. "Small-for-gestational Age Placentas Associate With an Increased Risk of Adverse Outcomes in Pregnancies Complicated By Either Type I or Type II Pre-gestational Diabetes Mellitus." The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2020, pp. 1-6.
Starikov R, Has P, Wu R, et al. Small-for-gestational age placentas associate with an increased risk of adverse outcomes in pregnancies complicated by either type I or type II pre-gestational diabetes mellitus. J Matern Fetal Neonatal Med. 2020.
Starikov, R., Has, P., Wu, R., Nelson, D. M., & He, M. (2020). Small-for-gestational age placentas associate with an increased risk of adverse outcomes in pregnancies complicated by either type I or type II pre-gestational diabetes mellitus. The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 1-6. https://doi.org/10.1080/14767058.2020.1767572
Starikov R, et al. Small-for-gestational Age Placentas Associate With an Increased Risk of Adverse Outcomes in Pregnancies Complicated By Either Type I or Type II Pre-gestational Diabetes Mellitus. J Matern Fetal Neonatal Med. 2020 May 19;1-6. PubMed PMID: 32429723.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small-for-gestational age placentas associate with an increased risk of adverse outcomes in pregnancies complicated by either type I or type II pre-gestational diabetes mellitus. AU - Starikov,Roman, AU - Has,Phinnara, AU - Wu,Robert, AU - Nelson,D Michael, AU - He,Mai, Y1 - 2020/05/19/ PY - 2020/5/21/entrez KW - Placenta KW - outcomes histopathology KW - pregestational diabetes mellitus risk KW - pregnancy KW - small for gestational age SP - 1 EP - 6 JF - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JO - J. Matern. Fetal. Neonatal. Med. N2 - Introduction: One-fifth of pregnancies with pre-gestational diabetes mellitus (pre-DM) yield placentas <10th percentile small for gestational age (SGA), compared to a non-diabetic population. We hypothesized that SGA placentas of women with pre-DM, whether type I (T1DM) or type II (T2DM), exhibit distinct histopathological changes and pregnancy outcomes compared to pre-DM pregnancies with an AGA placenta.Methods: We conducted a retrospective, cohort study of placentas from pregnant women enrolled in the Diabetes in Pregnancy Program at Brown University between 2003 and 2011, by comparing pre-DM patients with SGA placentas to pre-DM patients with AGA placental weights.Results: The SGA placenta groups were associated with an increased risk for adverse clinical outcomes, compared to AGA placentas in pregnancies complicated by either T1DM or T2DM. Compared to their AGA pre-DM counterparts, T1DM, SGA placentas show increased peri-villous fibrin/fibrinoid deposition, thrombosis in fetal blood vessels, and meconium staining. Moreover, the histopathology of SGA placentas from T2DM is characterized by decidual vasculopathy, accelerated villous maturity, and erythroblastosis, compared to T2DM AGA placentas. The contrasting placental pathologies between the two pre-DM SGA phenotypes evolved independent of patient demographics and were unrelated to indicators of the glycemic control present at early gestational ages.Discussion: A sub-population of pre-DM women with either T1DM or T2DM diabetes that have an SGA placenta are at increased risk for adverse clinical outcomes in pregnancy, compared to pre-DM women with AGA placental weights. SN - 1476-4954 UR - https://www.unboundmedicine.com/medline/citation/32429723/Small-for-gestational_age_placentas_associate_with_an_increased_risk_of_adverse_outcomes_in_pregnancies_complicated_by_either_type_I_or_type_II_pre-gestational_diabetes_mellitus L2 - http://www.tandfonline.com/doi/full/10.1080/14767058.2020.1767572 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.