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A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease.
Lipids Health Dis. 2020 May 19; 19(1):97.LH

Abstract

OBJECTIVES

Numerous studies have reported that lipid metabolic abnormalities may play an important role in the development of Parkinson's disease (PD), with mixed results. This meta-analysis aims to systematically assess the relationship between serum cholesterol or triglyceride and the PD risk and to further determine the role of dyslipidemia in potential predictive value.

METHODS

This research systematically consulted and screened observational studies to evaluate the association of serum lipids with the risk of PD as of April 01, 2020 based on the inclusion and exclusion criteria. Two researchers screened and extracted the data independently. Then this article summarized the characteristics of all clinical studies and collected the corresponding data to perform pooled and sensitivity analyses. The meta-analysis was performed by using the RevMan 5.3 software after data extraction, quality assessment and analysis of publication bias.

RESULTS

Twenty-one related studies (13 case-control and 8 cohort studies) were selected with a total of 980,180 subjects, including 11,188 PD patients. Meta-analysis showed that higher levels of serum triglyceride (S-TG) [standard mean different (SMD) = - 0.26 (95% confidence interval (CI): - 0.39 to - 0.13, p<0.00001), relative risk (RR) = 0.67 (95% CI: 0.60 to 0.75, p<0.00001)] could be considered as protective factors for the pathogenesis of PD. However, there was no significant association between serum high density lipoprotein cholesterol (S-HDL) and the risk of PD. Meanwhile, serum low density lipoprotein cholesterol (S-LDL) [SMD = -0.26 (95% CI: - 0.43 to - 0.07, p = 0.006), RR = 0.76 (95% CI: 0.59 to 0.97, p = 0.03)] and serum total cholesterol (S-TC) levels [SMD = -0.21 (95% CI: - 0.33 to - 0.10, p = 0.0002), RR = 0.86 (95% CI: 0.77 to 0.97, p = 0.01)] were negatively associated with PD risk.

CONCLUSIONS

This systematic review suggests that elevated serum levels of TG, LDL and TC may be protective factors for the pathogenesis of PD. Further longitudinal and well-designed prospective studies with a large sample size are needed to confirm the findings in this meta-analysis.

Authors+Show Affiliations

Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi Province, China.Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.Department of Science and Education, Heping Hospital Affiliated to Changzhi Medical College, Changzhi city, Shanxi, P.R. China.Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi Province, China.Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi Province, China. yujian80@163.com.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China. zhangxy9@gmail.com. Department of Psychology, University of Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing, 100101, China. zhangxy9@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32430016

Citation

Fu, Xiaoxue, et al. "A Systematic Review and Meta-analysis of Serum Cholesterol and Triglyceride Levels in Patients With Parkinson's Disease." Lipids in Health and Disease, vol. 19, no. 1, 2020, p. 97.
Fu X, Wang Y, He X, et al. A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease. Lipids Health Dis. 2020;19(1):97.
Fu, X., Wang, Y., He, X., Li, H., Liu, H., & Zhang, X. (2020). A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease. Lipids in Health and Disease, 19(1), 97. https://doi.org/10.1186/s12944-020-01284-w
Fu X, et al. A Systematic Review and Meta-analysis of Serum Cholesterol and Triglyceride Levels in Patients With Parkinson's Disease. Lipids Health Dis. 2020 May 19;19(1):97. PubMed PMID: 32430016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review and meta-analysis of serum cholesterol and triglyceride levels in patients with Parkinson's disease. AU - Fu,Xiaoxue, AU - Wang,Yu, AU - He,Xiaofeng, AU - Li,Hongyu, AU - Liu,Hong, AU - Zhang,Xiangyang, Y1 - 2020/05/19/ PY - 2019/11/05/received PY - 2020/05/12/accepted PY - 2020/5/21/entrez PY - 2020/5/21/pubmed PY - 2021/3/18/medline KW - Low density lipoprotein cholesterol KW - Meta-analysis KW - Parkinson’s disease KW - Systematic review KW - Total cholesterol KW - Triglyceride SP - 97 EP - 97 JF - Lipids in health and disease JO - Lipids Health Dis VL - 19 IS - 1 N2 - OBJECTIVES: Numerous studies have reported that lipid metabolic abnormalities may play an important role in the development of Parkinson's disease (PD), with mixed results. This meta-analysis aims to systematically assess the relationship between serum cholesterol or triglyceride and the PD risk and to further determine the role of dyslipidemia in potential predictive value. METHODS: This research systematically consulted and screened observational studies to evaluate the association of serum lipids with the risk of PD as of April 01, 2020 based on the inclusion and exclusion criteria. Two researchers screened and extracted the data independently. Then this article summarized the characteristics of all clinical studies and collected the corresponding data to perform pooled and sensitivity analyses. The meta-analysis was performed by using the RevMan 5.3 software after data extraction, quality assessment and analysis of publication bias. RESULTS: Twenty-one related studies (13 case-control and 8 cohort studies) were selected with a total of 980,180 subjects, including 11,188 PD patients. Meta-analysis showed that higher levels of serum triglyceride (S-TG) [standard mean different (SMD) = - 0.26 (95% confidence interval (CI): - 0.39 to - 0.13, p<0.00001), relative risk (RR) = 0.67 (95% CI: 0.60 to 0.75, p<0.00001)] could be considered as protective factors for the pathogenesis of PD. However, there was no significant association between serum high density lipoprotein cholesterol (S-HDL) and the risk of PD. Meanwhile, serum low density lipoprotein cholesterol (S-LDL) [SMD = -0.26 (95% CI: - 0.43 to - 0.07, p = 0.006), RR = 0.76 (95% CI: 0.59 to 0.97, p = 0.03)] and serum total cholesterol (S-TC) levels [SMD = -0.21 (95% CI: - 0.33 to - 0.10, p = 0.0002), RR = 0.86 (95% CI: 0.77 to 0.97, p = 0.01)] were negatively associated with PD risk. CONCLUSIONS: This systematic review suggests that elevated serum levels of TG, LDL and TC may be protective factors for the pathogenesis of PD. Further longitudinal and well-designed prospective studies with a large sample size are needed to confirm the findings in this meta-analysis. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/32430016/A_systematic_review_and_meta_analysis_of_serum_cholesterol_and_triglyceride_levels_in_patients_with_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -