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Clinical Features and Experimental Models of Cerebral Small Vessel Disease.
Front Aging Neurosci. 2020; 12:109.FA

Abstract

Cerebral small vessel disease (SVD) refers to a group of disease conditions affecting the cerebral small vessels, which include the small arteries, arterioles, capillaries, and postcapillary venules in the brain. SVD is the primary cause of vascular cognitive impairment and gait disturbances in aged people. There are several types of SVD, though arteriolosclerosis, which is mainly associated with hypertension, aging, and diabetes mellitus, and cerebral amyloid angiopathy (CAA) comprise most SVD cases. The pathology of arteriolosclerosis-induced SVD is characterized by fibrinoid necrosis and lipohyalinosis, while CAA-associated SVD is characterized by progressive deposition of amyloid beta (Aβ) protein in the cerebral vessels. Brain magnetic resonance imaging (MRI) has been used for examination of SVD lesions; typical lesions are characterized by white matter hyperintensity, lacunar infarcts, enlargement of perivascular spaces (EPVS), microbleeds, cortical superficial siderosis (cSS), and cortical microinfarcts. The microvascular changes that occur in the small vessels are difficult to identify clearly; however, these consequent image findings can represent the SVD. There are two main strategies for prevention and treatment of SVD, i.e., pharmacotherapy and lifestyle modification. In this review, we discuss clinical features of SVD, experimental models replicating SVD, and treatments to further understand the pathological and clinical features of SVD.

Authors+Show Affiliations

Department of Neurology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan.Department of Neurology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan.Department of Neurology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan.Department of Neurology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan.Department of Neurology, Mie University Graduate School of Medicine, Mie University, Tsu, Japan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32431603

Citation

Shindo, Akihiro, et al. "Clinical Features and Experimental Models of Cerebral Small Vessel Disease." Frontiers in Aging Neuroscience, vol. 12, 2020, p. 109.
Shindo A, Ishikawa H, Ii Y, et al. Clinical Features and Experimental Models of Cerebral Small Vessel Disease. Front Aging Neurosci. 2020;12:109.
Shindo, A., Ishikawa, H., Ii, Y., Niwa, A., & Tomimoto, H. (2020). Clinical Features and Experimental Models of Cerebral Small Vessel Disease. Frontiers in Aging Neuroscience, 12, 109. https://doi.org/10.3389/fnagi.2020.00109
Shindo A, et al. Clinical Features and Experimental Models of Cerebral Small Vessel Disease. Front Aging Neurosci. 2020;12:109. PubMed PMID: 32431603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical Features and Experimental Models of Cerebral Small Vessel Disease. AU - Shindo,Akihiro, AU - Ishikawa,Hidehiro, AU - Ii,Yuichiro, AU - Niwa,Atsushi, AU - Tomimoto,Hidekazu, Y1 - 2020/05/05/ PY - 2020/01/22/received PY - 2020/03/30/accepted PY - 2020/5/21/entrez PY - 2020/5/21/pubmed PY - 2020/5/21/medline KW - Alzheimer’s disease KW - blood-brain barrier KW - lacuna KW - neurovascular unit KW - white matter SP - 109 EP - 109 JF - Frontiers in aging neuroscience JO - Front Aging Neurosci VL - 12 N2 - Cerebral small vessel disease (SVD) refers to a group of disease conditions affecting the cerebral small vessels, which include the small arteries, arterioles, capillaries, and postcapillary venules in the brain. SVD is the primary cause of vascular cognitive impairment and gait disturbances in aged people. There are several types of SVD, though arteriolosclerosis, which is mainly associated with hypertension, aging, and diabetes mellitus, and cerebral amyloid angiopathy (CAA) comprise most SVD cases. The pathology of arteriolosclerosis-induced SVD is characterized by fibrinoid necrosis and lipohyalinosis, while CAA-associated SVD is characterized by progressive deposition of amyloid beta (Aβ) protein in the cerebral vessels. Brain magnetic resonance imaging (MRI) has been used for examination of SVD lesions; typical lesions are characterized by white matter hyperintensity, lacunar infarcts, enlargement of perivascular spaces (EPVS), microbleeds, cortical superficial siderosis (cSS), and cortical microinfarcts. The microvascular changes that occur in the small vessels are difficult to identify clearly; however, these consequent image findings can represent the SVD. There are two main strategies for prevention and treatment of SVD, i.e., pharmacotherapy and lifestyle modification. In this review, we discuss clinical features of SVD, experimental models replicating SVD, and treatments to further understand the pathological and clinical features of SVD. SN - 1663-4365 UR - https://www.unboundmedicine.com/medline/citation/32431603/Clinical_Features_and_Experimental_Models_of_Cerebral_Small_Vessel_Disease L2 - https://doi.org/10.3389/fnagi.2020.00109 DB - PRIME DP - Unbound Medicine ER -
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