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Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri.
Front Immunol. 2020; 11:682.FI

Abstract

"Location, location, and location": according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T cells to recirculate throughout blood or lymph, or to stably reside in certain tissues, turned out to determine immunity to pathogens, and tumors. If location matters also for human beings, the inspiring environment of Capri Island has contributed to the success of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology focused on "T cell memory," held in Anacapri from October 12, 2018 to October 15, 2018. In this minireview, we would like to highlight some novel concepts about T cell migration and residency and discuss their implications in relation to recent advances in the field, including the mechanisms regulating compartmentalization and cell cycle entry of T cells during activation, the role of mitochondrial metabolism in T cell movement, and the residency of regulatory T cells.

Authors+Show Affiliations

Dipartimento di Scienze Cliniche Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Rome, Italy. Laboratory Affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.Department of Biology, University of Rome Tor Vergata, Rome, Italy.Institute of Molecular Biology and Pathology, National Research Council (CNR), Rome, Italy. Dipartimento di Medicina Molecolare (DMM), Sapienza Università di Roma, Rome, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32431695

Citation

Piconese, Silvia, et al. "Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri." Frontiers in Immunology, vol. 11, 2020, p. 682.
Piconese S, Campello S, Natalini A. Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri. Front Immunol. 2020;11:682.
Piconese, S., Campello, S., & Natalini, A. (2020). Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri. Frontiers in Immunology, 11, 682. https://doi.org/10.3389/fimmu.2020.00682
Piconese S, Campello S, Natalini A. Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri. Front Immunol. 2020;11:682. PubMed PMID: 32431695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recirculation and Residency of T Cells and Tregs: Lessons Learnt in Anacapri. AU - Piconese,Silvia, AU - Campello,Silvia, AU - Natalini,Ambra, Y1 - 2020/05/05/ PY - 2020/01/10/received PY - 2020/03/26/accepted PY - 2020/5/21/entrez PY - 2020/5/21/pubmed PY - 2020/5/21/medline KW - T cells KW - Tregs KW - cell cycle KW - cell migration KW - recirculation SP - 682 EP - 682 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - "Location, location, and location": according to this mantra, the place where living beings settle has a key impact on the success of their activities; in turn, the living beings can, in many ways, modify their environment. This idea has now become more and more true for T cells. The ability of T cells to recirculate throughout blood or lymph, or to stably reside in certain tissues, turned out to determine immunity to pathogens, and tumors. If location matters also for human beings, the inspiring environment of Capri Island has contributed to the success of the EFIS-EJI Ruggero Ceppellini Advanced School of Immunology focused on "T cell memory," held in Anacapri from October 12, 2018 to October 15, 2018. In this minireview, we would like to highlight some novel concepts about T cell migration and residency and discuss their implications in relation to recent advances in the field, including the mechanisms regulating compartmentalization and cell cycle entry of T cells during activation, the role of mitochondrial metabolism in T cell movement, and the residency of regulatory T cells. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/32431695/Recirculation_and_Residency_of_T_Cells_and_Tregs:_Lessons_Learnt_in_Anacapri L2 - https://doi.org/10.3389/fimmu.2020.00682 DB - PRIME DP - Unbound Medicine ER -
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