Tags

Type your tag names separated by a space and hit enter

Progestogens in luteal support.
Horm Mol Biol Clin Investig. 2020 May 20 [Online ahead of print]HM

Abstract

Progestational agents are often prescribed to increase the clinical pregnancy rate in assisted reproduction. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. Progesterone production from the corpus luteum is essential for reproduction, but assisted reproductive technologies (ART) can impair luteal function. ART cycles can be classified into three, fresh cycles in which there may or may not be luteal insufficiency, agonist or antagonist cycles in which there is luteal insufficiency, and luteal support is essential, and donor cycles, in which there is no corpus luteum, and a luteal phase has to be created. However, there is no adequate diagnostic test for luteal insufficiency. This article summarises the effect of various progestogens, progesterone itself whether administered vaginally, intra-muscularly, rectally or subcutaneously, and the effect of the progestogen, dydrogesterone. The time of commencement and cessation of therapy are also discussed. Progestogens are also often used to treat threatened and recurrent miscarriage. In these patients progestogen supplementation may need to be prolonged. In threatened miscarriage, until after all bleeding stops, and in recurrent miscarriage, at least as long as the luteo-placental shift.

Authors+Show Affiliations

Department of Obstetrics & Gynecology, Sheba Medical Center, Tel Hashomer, 52621,Israel.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32432564

Citation

Carp, Howard J A.. "Progestogens in Luteal Support." Hormone Molecular Biology and Clinical Investigation, 2020.
Carp HJA. Progestogens in luteal support. Horm Mol Biol Clin Investig. 2020.
Carp, H. J. A. (2020). Progestogens in luteal support. Hormone Molecular Biology and Clinical Investigation. https://doi.org/10.1515/hmbci-2019-0067
Carp HJA. Progestogens in Luteal Support. Horm Mol Biol Clin Investig. 2020 May 20; PubMed PMID: 32432564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progestogens in luteal support. A1 - Carp,Howard J A, Y1 - 2020/05/20/ PY - 2019/11/14/received PY - 2020/03/31/accepted PY - 2020/5/21/entrez KW - ART KW - IVF KW - luteal support KW - progesterone KW - progestogens JF - Hormone molecular biology and clinical investigation JO - Horm Mol Biol Clin Investig N2 - Progestational agents are often prescribed to increase the clinical pregnancy rate in assisted reproduction. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. Progesterone production from the corpus luteum is essential for reproduction, but assisted reproductive technologies (ART) can impair luteal function. ART cycles can be classified into three, fresh cycles in which there may or may not be luteal insufficiency, agonist or antagonist cycles in which there is luteal insufficiency, and luteal support is essential, and donor cycles, in which there is no corpus luteum, and a luteal phase has to be created. However, there is no adequate diagnostic test for luteal insufficiency. This article summarises the effect of various progestogens, progesterone itself whether administered vaginally, intra-muscularly, rectally or subcutaneously, and the effect of the progestogen, dydrogesterone. The time of commencement and cessation of therapy are also discussed. Progestogens are also often used to treat threatened and recurrent miscarriage. In these patients progestogen supplementation may need to be prolonged. In threatened miscarriage, until after all bleeding stops, and in recurrent miscarriage, at least as long as the luteo-placental shift. SN - 1868-1891 UR - https://www.unboundmedicine.com/medline/citation/32432564/Progestogens_in_luteal_support_ L2 - https://www.degruyter.com/doi/10.1515/hmbci-2019-0067 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.