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[Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases].
Zhongguo Dang Dai Er Ke Za Zhi. 2020 May; 22(5):488-493.ZD

Abstract

OBJECTIVE

To study the clinical features of vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children with neurological symptoms at disease onset.

METHODS

A retrospective analysis was performed on the medical data of 88 children with the initial symptoms of the nervous system, such as transient loss of consciousness, dizziness, headache, and convulsion, who were finally diagnosed with VVS or POTS.

RESULTS

Of the 88 children, there were 35 boys (40%) and 53 girls (60%), with an age of 4-15 years. The peak age of onset was between 10 and 13 years. All the children had the initial symptoms of transient loss of consciousness, dizziness, headache, and convulsion. Nervous system diseases were excluded by electroencephalography, cerebrospinal fluid examination, and cranial MRI. Of the 88 children, 53 (60%) were confirmed with VVS, and 35 (40%) with POTS, according to the results of head-up tilt test (HUTT). Five children with the initial symptom of transient loss of consciousness were misdiagnosed with epilepsy. Predisposing factors were determined for 59 children (67%), and prolonged standing was the most common factor, followed by change in body position and strenuous exercise. Premonitory symptoms were observed in 66 children (75%), among which chest discomfort was the most common symptom, followed by gastrointestinal symptoms (nausea, vomiting, and abdominal pain) and pale complexion. All 88 children received health education and exercise for autonomic nerve function, among whom 53 children with VVS were given oral rehydration salts and 35 children with POTS were given oral rehydration salts and metoprolol. All 88 children were followed up for 18 months, and the response rates to the above treatment at 3, 6, 12, and 18 months of follow-up were 87%, 93%, 93%, and 90% respectively.

CONCLUSIONS

In addition to nervous system diseases, functional cardiovascular diseases including VVS and POTS should be considered for children with the initial symptoms of transient loss of consciousness, dizziness, headache, and convulsion. HUTT can be used to make a confirmed diagnosis, and the early treatment can achieve a good outcome.

Links

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Authors+Show Affiliations

Wang AP
Department of Pediatrics, Second Xiangya Hospital of Central South University, Changsha 410011, China. liuliqun@csu.edu.cn.
Zheng J
No affiliation info available
Wang C
No affiliation info available
Cai H
No affiliation info available
Mao DA
No affiliation info available
Lin P
No affiliation info available
Li F
No affiliation info available
Luo HY
No affiliation info available
Xiong JJ
No affiliation info available
Liu LQ
No affiliation info available

MeSH

AdolescentChildChild, PreschoolFemaleHumansMalePostural Orthostatic Tachycardia SyndromePostureRetrospective StudiesSyncope, VasovagalTilt-Table Test

Pub Type(s)

Journal Article

Language

chi

PubMed ID

32434646

Citation

Wang, Ai-Ping, et al. "[Vasovagal Syncope or Postural Orthostatic Tachycardia Syndrome in Children With Neurological Symptoms at Disease Onset: a Clinical Analysis of 88 Cases]." Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, vol. 22, no. 5, 2020, pp. 488-493.
Wang AP, Zheng J, Wang C, et al. [Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(5):488-493.
Wang, A. P., Zheng, J., Wang, C., Cai, H., Mao, D. A., Lin, P., Li, F., Luo, H. Y., Xiong, J. J., & Liu, L. Q. (2020). [Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 22(5), 488-493.
Wang AP, et al. [Vasovagal Syncope or Postural Orthostatic Tachycardia Syndrome in Children With Neurological Symptoms at Disease Onset: a Clinical Analysis of 88 Cases]. Zhongguo Dang Dai Er Ke Za Zhi. 2020;22(5):488-493. PubMed PMID: 32434646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Vasovagal syncope or postural orthostatic tachycardia syndrome in children with neurological symptoms at disease onset: a clinical analysis of 88 cases]. AU - Wang,Ai-Ping, AU - Zheng,Jing, AU - Wang,Cheng, AU - Cai,Hong, AU - Mao,Ding-An, AU - Lin,Ping, AU - Li,Fang, AU - Luo,Hai-Yan, AU - Xiong,Jia-Jia, AU - Liu,Li-Qun, PY - 2020/5/22/entrez PY - 2020/5/22/pubmed PY - 2020/7/28/medline SP - 488 EP - 493 JF - Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics JO - Zhongguo Dang Dai Er Ke Za Zhi VL - 22 IS - 5 N2 - OBJECTIVE: To study the clinical features of vasovagal syncope (VVS) and postural orthostatic tachycardia syndrome (POTS) in children with neurological symptoms at disease onset. METHODS: A retrospective analysis was performed on the medical data of 88 children with the initial symptoms of the nervous system, such as transient loss of consciousness, dizziness, headache, and convulsion, who were finally diagnosed with VVS or POTS. RESULTS: Of the 88 children, there were 35 boys (40%) and 53 girls (60%), with an age of 4-15 years. The peak age of onset was between 10 and 13 years. All the children had the initial symptoms of transient loss of consciousness, dizziness, headache, and convulsion. Nervous system diseases were excluded by electroencephalography, cerebrospinal fluid examination, and cranial MRI. Of the 88 children, 53 (60%) were confirmed with VVS, and 35 (40%) with POTS, according to the results of head-up tilt test (HUTT). Five children with the initial symptom of transient loss of consciousness were misdiagnosed with epilepsy. Predisposing factors were determined for 59 children (67%), and prolonged standing was the most common factor, followed by change in body position and strenuous exercise. Premonitory symptoms were observed in 66 children (75%), among which chest discomfort was the most common symptom, followed by gastrointestinal symptoms (nausea, vomiting, and abdominal pain) and pale complexion. All 88 children received health education and exercise for autonomic nerve function, among whom 53 children with VVS were given oral rehydration salts and 35 children with POTS were given oral rehydration salts and metoprolol. All 88 children were followed up for 18 months, and the response rates to the above treatment at 3, 6, 12, and 18 months of follow-up were 87%, 93%, 93%, and 90% respectively. CONCLUSIONS: In addition to nervous system diseases, functional cardiovascular diseases including VVS and POTS should be considered for children with the initial symptoms of transient loss of consciousness, dizziness, headache, and convulsion. HUTT can be used to make a confirmed diagnosis, and the early treatment can achieve a good outcome. SN - 1008-8830 UR - https://www.unboundmedicine.com/medline/citation/32434646/[Vasovagal_syncope_or_postural_orthostatic_tachycardia_syndrome_in_children_with_neurological_symptoms_at_disease_onset:_a_clinical_analysis_of_88_cases]_ DB - PRIME DP - Unbound Medicine ER -