Citation
Yu, Jingyou, et al. "DNA Vaccine Protection Against SARS-CoV-2 in Rhesus Macaques." Science (New York, N.Y.), vol. 369, no. 6505, 2020, pp. 806-811.
Yu J, Tostanoski LH, Peter L, et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 2020;369(6505):806-811.
Yu, J., Tostanoski, L. H., Peter, L., Mercado, N. B., McMahan, K., Mahrokhian, S. H., Nkolola, J. P., Liu, J., Li, Z., Chandrashekar, A., Martinez, D. R., Loos, C., Atyeo, C., Fischinger, S., Burke, J. S., Slein, M. D., Chen, Y., Zuiani, A., Lelis, F. J. N., ... Barouch, D. H. (2020). DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science (New York, N.Y.), 369(6505), 806-811. https://doi.org/10.1126/science.abc6284
Yu J, et al. DNA Vaccine Protection Against SARS-CoV-2 in Rhesus Macaques. Science. 2020 08 14;369(6505):806-811. PubMed PMID: 32434945.
TY - JOUR
T1 - DNA vaccine protection against SARS-CoV-2 in rhesus macaques.
AU - Yu,Jingyou,
AU - Tostanoski,Lisa H,
AU - Peter,Lauren,
AU - Mercado,Noe B,
AU - McMahan,Katherine,
AU - Mahrokhian,Shant H,
AU - Nkolola,Joseph P,
AU - Liu,Jinyan,
AU - Li,Zhenfeng,
AU - Chandrashekar,Abishek,
AU - Martinez,David R,
AU - Loos,Carolin,
AU - Atyeo,Caroline,
AU - Fischinger,Stephanie,
AU - Burke,John S,
AU - Slein,Matthew D,
AU - Chen,Yuezhou,
AU - Zuiani,Adam,
AU - Lelis,Felipe J N,
AU - Travers,Meghan,
AU - Habibi,Shaghayegh,
AU - Pessaint,Laurent,
AU - Van Ry,Alex,
AU - Blade,Kelvin,
AU - Brown,Renita,
AU - Cook,Anthony,
AU - Finneyfrock,Brad,
AU - Dodson,Alan,
AU - Teow,Elyse,
AU - Velasco,Jason,
AU - Zahn,Roland,
AU - Wegmann,Frank,
AU - Bondzie,Esther A,
AU - Dagotto,Gabriel,
AU - Gebre,Makda S,
AU - He,Xuan,
AU - Jacob-Dolan,Catherine,
AU - Kirilova,Marinela,
AU - Kordana,Nicole,
AU - Lin,Zijin,
AU - Maxfield,Lori F,
AU - Nampanya,Felix,
AU - Nityanandam,Ramya,
AU - Ventura,John D,
AU - Wan,Huahua,
AU - Cai,Yongfei,
AU - Chen,Bing,
AU - Schmidt,Aaron G,
AU - Wesemann,Duane R,
AU - Baric,Ralph S,
AU - Alter,Galit,
AU - Andersen,Hanne,
AU - Lewis,Mark G,
AU - Barouch,Dan H,
Y1 - 2020/05/20/
PY - 2020/05/05/received
PY - 2020/05/16/accepted
PY - 2020/5/22/pubmed
PY - 2020/8/28/medline
PY - 2020/5/22/entrez
SP - 806
EP - 811
JF - Science (New York, N.Y.)
JO - Science
VL - 369
IS - 6505
N2 - The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made the development of a vaccine a top biomedical priority. In this study, we developed a series of DNA vaccine candidates expressing different forms of the SARS-CoV-2 spike (S) protein and evaluated them in 35 rhesus macaques. Vaccinated animals developed humoral and cellular immune responses, including neutralizing antibody titers at levels comparable to those found in convalescent humans and macaques infected with SARS-CoV-2. After vaccination, all animals were challenged with SARS-CoV-2, and the vaccine encoding the full-length S protein resulted in >3.1 and >3.7 log10 reductions in median viral loads in bronchoalveolar lavage and nasal mucosa, respectively, as compared with viral loads in sham controls. Vaccine-elicited neutralizing antibody titers correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate vaccine protection against SARS-CoV-2 in nonhuman primates.
SN - 1095-9203
UR - https://www.unboundmedicine.com/medline/citation/32434945/DNA_vaccine_protection_against_SARS_CoV_2_in_rhesus_macaques_
DB - PRIME
DP - Unbound Medicine
ER -