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Biotransformation of arsenic and toxicological implication of arsenic metabolites.
Arch Toxicol. 2020 Aug; 94(8):2587-2601.AT

Abstract

Arsenic is a well-known environmental carcinogen and chronic exposure to arsenic through drinking water has been reported to cause skin, bladder and lung cancers, with arsenic metabolites being implicated in the pathogenesis. In contrast, arsenic trioxide (As2O3) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, in which the binding of arsenite (iAsIII) to promyelocytic leukemia (PML) protein is the proposed initial step. These findings on the two-edged sword characteristics of arsenic suggest that after entry into cells, arsenic reaches the nucleus and triggers various nuclear events. Arsenic is reduced, conjugated with glutathione, and methylated in the cytosol. These biotransformations, including the production of reactive metabolic intermediates, appear to determine the intracellular dynamics, target organs, and biological functions of arsenic.

Authors+Show Affiliations

Center for Health and Environmental Risk Research, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan. seishiro@nies.go.jp.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32435915

Citation

Hirano, Seishiro. "Biotransformation of Arsenic and Toxicological Implication of Arsenic Metabolites." Archives of Toxicology, vol. 94, no. 8, 2020, pp. 2587-2601.
Hirano S. Biotransformation of arsenic and toxicological implication of arsenic metabolites. Arch Toxicol. 2020;94(8):2587-2601.
Hirano, S. (2020). Biotransformation of arsenic and toxicological implication of arsenic metabolites. Archives of Toxicology, 94(8), 2587-2601. https://doi.org/10.1007/s00204-020-02772-9
Hirano S. Biotransformation of Arsenic and Toxicological Implication of Arsenic Metabolites. Arch Toxicol. 2020;94(8):2587-2601. PubMed PMID: 32435915.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biotransformation of arsenic and toxicological implication of arsenic metabolites. A1 - Hirano,Seishiro, Y1 - 2020/05/20/ PY - 2020/02/25/received PY - 2020/05/04/accepted PY - 2020/5/22/pubmed PY - 2020/5/22/medline PY - 2020/5/22/entrez KW - Arsenic KW - Arsine KW - Glutathione KW - Metalloid KW - Methylation KW - Promyelocytic leukemia KW - Reduction SP - 2587 EP - 2601 JF - Archives of toxicology JO - Arch. Toxicol. VL - 94 IS - 8 N2 - Arsenic is a well-known environmental carcinogen and chronic exposure to arsenic through drinking water has been reported to cause skin, bladder and lung cancers, with arsenic metabolites being implicated in the pathogenesis. In contrast, arsenic trioxide (As2O3) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, in which the binding of arsenite (iAsIII) to promyelocytic leukemia (PML) protein is the proposed initial step. These findings on the two-edged sword characteristics of arsenic suggest that after entry into cells, arsenic reaches the nucleus and triggers various nuclear events. Arsenic is reduced, conjugated with glutathione, and methylated in the cytosol. These biotransformations, including the production of reactive metabolic intermediates, appear to determine the intracellular dynamics, target organs, and biological functions of arsenic. SN - 1432-0738 UR - https://www.unboundmedicine.com/medline/citation/32435915/Biotransformation_of_arsenic_and_toxicological_implication_of_arsenic_metabolites L2 - https://doi.org/10.1007/s00204-020-02772-9 DB - PRIME DP - Unbound Medicine ER -
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