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Could COVID-19 have an impact on male fertility?
Andrologia. 2020 Jul; 52(6):e13654.A

Abstract

The pandemic caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to several hypotheses of functional alteration of different organs. The direct influence of this virus on the male urogenital organs is still to be evaluated. However some hypotheses can already be made, especially in the andrological field, for the biological similarity of the SARS-CoV and SARS-CoV2. As well as SARS-CoV, SARS CoV-2 uses the 'Angiotensin Converting Enzyme-2' (ACE2) as a receptor to enter human cells. It was found that ACE2, Angiotensin (1-7) and its MAS receptors are present, over in the lung, also in the testicles, in particular in Leydig and Sertoli cells. A first hypothesis is that the virus could enter the testicle and lead to alterations in testicular functionality. A second hypothesis is that the binding of the virus to the ACE2 receptor, could cause an excess of ACE2 and give rise to a typical inflammatory response. The inflammatory cells could interfere with the function of Leydig and Sertoli cells. Both hypotheses should be evaluated and confirmed, in order to possibly monitor fertility in patients COVID-19+.

Authors+Show Affiliations

Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.Andrology and Urogynecology Clinic, Santa Maria Terni Hospital, University of Perugia, Terni, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32436229

Citation

Illiano, Ester, et al. "Could COVID-19 Have an Impact On Male Fertility?" Andrologia, vol. 52, no. 6, 2020, pp. e13654.
Illiano E, Trama F, Costantini E. Could COVID-19 have an impact on male fertility? Andrologia. 2020;52(6):e13654.
Illiano, E., Trama, F., & Costantini, E. (2020). Could COVID-19 have an impact on male fertility? Andrologia, 52(6), e13654. https://doi.org/10.1111/and.13654
Illiano E, Trama F, Costantini E. Could COVID-19 Have an Impact On Male Fertility. Andrologia. 2020;52(6):e13654. PubMed PMID: 32436229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Could COVID-19 have an impact on male fertility? AU - Illiano,Ester, AU - Trama,Francesco, AU - Costantini,Elisabetta, Y1 - 2020/05/21/ PY - 2020/03/30/received PY - 2020/04/27/revised PY - 2020/04/29/accepted PY - 2020/5/22/pubmed PY - 2020/6/18/medline PY - 2020/5/22/entrez KW - COVID-19 KW - angiotensin-converting enzyme 2 KW - male infertility SP - e13654 EP - e13654 JF - Andrologia JO - Andrologia VL - 52 IS - 6 N2 - The pandemic caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to several hypotheses of functional alteration of different organs. The direct influence of this virus on the male urogenital organs is still to be evaluated. However some hypotheses can already be made, especially in the andrological field, for the biological similarity of the SARS-CoV and SARS-CoV2. As well as SARS-CoV, SARS CoV-2 uses the 'Angiotensin Converting Enzyme-2' (ACE2) as a receptor to enter human cells. It was found that ACE2, Angiotensin (1-7) and its MAS receptors are present, over in the lung, also in the testicles, in particular in Leydig and Sertoli cells. A first hypothesis is that the virus could enter the testicle and lead to alterations in testicular functionality. A second hypothesis is that the binding of the virus to the ACE2 receptor, could cause an excess of ACE2 and give rise to a typical inflammatory response. The inflammatory cells could interfere with the function of Leydig and Sertoli cells. Both hypotheses should be evaluated and confirmed, in order to possibly monitor fertility in patients COVID-19+. SN - 1439-0272 UR - https://www.unboundmedicine.com/medline/citation/32436229/Could_COVID_19_have_an_impact_on_male_fertility L2 - https://doi.org/10.1111/and.13654 DB - PRIME DP - Unbound Medicine ER -