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Fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonists in the treatment of Japanese people with type 2 diabetes: An innovative solution to a complex therapeutic challenge.
Diabetes Obes Metab. 2020 May 20 [Online ahead of print]DO

Abstract

Over 10 million people in Japan have known or suspected type 2 diabetes (T2D), and this number is expected to rise. Although many people require therapy escalation due to the progressive nature of T2D, this appears to be suboptimal in Japanese real-world clinical practice. Insulin therapy tends to be introduced only when glycaemic control is very poor (mean HbA1c >9%). Although basal insulin (BI) therapy is effective in reducing fasting plasma glucose (FPG), postprandial plasma glucose (PPG) often remains uncontrolled. Basal-bolus insulin regimens are complex and carry the risk of weight gain and hypoglycaemia. Recently, fixed-ratio combinations (FRCs) of BI and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown efficacy in reducing both FPG and PPG with a single injection and without increased risk of hypoglycaemia or weight gain. IDegLira, a titratable FRC of insulin degludec (100 U/mL) and liraglutide is currently available in Japan and USA/EU at a ratio of 1 U (unit):0.036 mg. iGlarLixi (insulin glargine 100 U/mL and lixisenatide at a ratio of 1:1 (20 U/20 μg) has recently been approved in Japan. Phase 3 trials in Japan for IDegLira (DUAL Japan) and iGlarLixi (LixiLan JP) have shown that both FRCs are efficacious. This review provides an overview of IDegLira and iGlarLixi (Japanese formulation) and considers their potential use as new therapeutic options to address the clinical need for early glycaemic control in Japanese people with T2D. This article is protected by copyright. All rights reserved.

Authors+Show Affiliations

Division of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, Kurashiki, Japan.Medical Affairs, Tokyo, Japan.Medical Affairs, Guildford, UK. Department of Diabetes and Endocrinology, University of Swansea, Swansea, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32436323

Citation

Kaneto, Hideaki, et al. "Fixed-ratio Combination of Basal Insulin and Glucagon-like Peptide-1 Receptor Agonists in the Treatment of Japanese People With Type 2 Diabetes: an Innovative Solution to a Complex Therapeutic Challenge." Diabetes, Obesity & Metabolism, 2020.
Kaneto H, Koshida R, Baxter M. Fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonists in the treatment of Japanese people with type 2 diabetes: An innovative solution to a complex therapeutic challenge. Diabetes Obes Metab. 2020.
Kaneto, H., Koshida, R., & Baxter, M. (2020). Fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonists in the treatment of Japanese people with type 2 diabetes: An innovative solution to a complex therapeutic challenge. Diabetes, Obesity & Metabolism. https://doi.org/10.1111/dom.14095
Kaneto H, Koshida R, Baxter M. Fixed-ratio Combination of Basal Insulin and Glucagon-like Peptide-1 Receptor Agonists in the Treatment of Japanese People With Type 2 Diabetes: an Innovative Solution to a Complex Therapeutic Challenge. Diabetes Obes Metab. 2020 May 20; PubMed PMID: 32436323.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fixed-ratio combination of basal insulin and glucagon-like peptide-1 receptor agonists in the treatment of Japanese people with type 2 diabetes: An innovative solution to a complex therapeutic challenge. AU - Kaneto,Hideaki, AU - Koshida,Ryusuke, AU - Baxter,Mike, Y1 - 2020/05/20/ PY - 2020/02/28/received PY - 2020/05/12/revised PY - 2020/05/19/accepted PY - 2020/5/22/entrez KW - GLP-1 analogue KW - antidiabetic drug KW - glycaemic control KW - insulin therapy KW - type 2 diabetes JF - Diabetes, obesity & metabolism JO - Diabetes Obes Metab N2 - Over 10 million people in Japan have known or suspected type 2 diabetes (T2D), and this number is expected to rise. Although many people require therapy escalation due to the progressive nature of T2D, this appears to be suboptimal in Japanese real-world clinical practice. Insulin therapy tends to be introduced only when glycaemic control is very poor (mean HbA1c >9%). Although basal insulin (BI) therapy is effective in reducing fasting plasma glucose (FPG), postprandial plasma glucose (PPG) often remains uncontrolled. Basal-bolus insulin regimens are complex and carry the risk of weight gain and hypoglycaemia. Recently, fixed-ratio combinations (FRCs) of BI and glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown efficacy in reducing both FPG and PPG with a single injection and without increased risk of hypoglycaemia or weight gain. IDegLira, a titratable FRC of insulin degludec (100 U/mL) and liraglutide is currently available in Japan and USA/EU at a ratio of 1 U (unit):0.036 mg. iGlarLixi (insulin glargine 100 U/mL and lixisenatide at a ratio of 1:1 (20 U/20 μg) has recently been approved in Japan. Phase 3 trials in Japan for IDegLira (DUAL Japan) and iGlarLixi (LixiLan JP) have shown that both FRCs are efficacious. This review provides an overview of IDegLira and iGlarLixi (Japanese formulation) and considers their potential use as new therapeutic options to address the clinical need for early glycaemic control in Japanese people with T2D. This article is protected by copyright. All rights reserved. SN - 1463-1326 UR - https://www.unboundmedicine.com/medline/citation/32436323/Fixed-ratio_combination_of_basal_insulin_and_glucagon-like_peptide-1_receptor_agonists_in_the_treatment_of_Japanese_people_with_type_2_diabetes:_An_innovative_solution_to_a_complex_therapeutic_challenge L2 - https://doi.org/10.1111/dom.14095 DB - PRIME DP - Unbound Medicine ER -
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