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Effects of dabigatran and fondaparinux on degloving injuries: An experimental study.
Ulus Travma Acil Cerrahi Derg. 2020 May; 26(3):343-350.UT

Abstract

BACKGROUND

Management of the skin degloving injuries is still a problematic issue, and the avulsed part of the skin may become necrotic. We hypothesized that the anticoagulant pharmacological agents, fondaparinux and dabigatran may be beneficial in the treatment of degloving injuries by enhancing the viability of the reattached flap.

METHODS

Twenty four Wistar rats were divided into three groups as follows: control group (Group 1), fondaparinux group (Group 2) and dabigatran group (Group 3). A model of a degloving injury on the tail of rats was developed in all groups. After 15 minutes, the avulsed flaps were sutured back. Group 1 received 1ml/day saline intraperitoneally for 10 days. Group 2 received 0.3 ml/kg/day fondaparinux intraperitoneally for 10 days. Group 3 received 30 mg/kg/day dabigatran orally for 10 days. At the end of the treatments, gross morphological and histopathological tail tissue survivals were evaluated.

RESULTS

Histopathological examination of the fondaparinux and dabigatran groups revealed that the tail skin was mostly viable with mild inflammation. The mean necrotic length in tails and severity of inflammation was significantly higher in the control group compared to the fondaparinux and dabigatran groups (p<0.05). No statistically significant differences were noted between the fondaparinux and dabigatran groups in histopathologic evaluations. There was no significant difference in necrosis lengths and the other histopathological parameters between dabigatran and fondaparinux groups.

CONCLUSION

Dabigatran and fondaparinux improved tissue survival in skin degloving injuries concerning gross morphological and histopathological findings. However, the findings of this study should be supported and improved by new experimental and especially clinical studies.

Authors+Show Affiliations

Department of Plastic Reconstructive and Aesthetic Surgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş-Turkey.Department of Plastic Reconstructive and Aesthetic Surgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş-Turkey.Department of Pharmacology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş-Turkey.Department of Pathology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş-Turkey.Department of Plastic Reconstructive and Aesthetic Surgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş-Turkey.Department of Pediatric Surgery, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş-Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32436968

Citation

Ural, Alper, et al. "Effects of Dabigatran and Fondaparinux On Degloving Injuries: an Experimental Study." Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES, vol. 26, no. 3, 2020, pp. 343-350.
Ural A, Bilgen F, Altıntaş Aykan D, et al. Effects of dabigatran and fondaparinux on degloving injuries: An experimental study. Ulus Travma Acil Cerrahi Derg. 2020;26(3):343-350.
Ural, A., Bilgen, F., Altıntaş Aykan, D., Bahar, A. Y., Bekerecioğlu, M., & Altıntaş Ural, D. (2020). Effects of dabigatran and fondaparinux on degloving injuries: An experimental study. Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES, 26(3), 343-350. https://doi.org/10.14744/tjtes.2020.26678
Ural A, et al. Effects of Dabigatran and Fondaparinux On Degloving Injuries: an Experimental Study. Ulus Travma Acil Cerrahi Derg. 2020;26(3):343-350. PubMed PMID: 32436968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dabigatran and fondaparinux on degloving injuries: An experimental study. AU - Ural,Alper, AU - Bilgen,Fatma, AU - Altıntaş Aykan,Duygun, AU - Bahar,Abdulkadir Yasir, AU - Bekerecioğlu,Mehmet, AU - Altıntaş Ural,Dilan, PY - 2020/5/22/entrez PY - 2020/5/22/pubmed PY - 2020/5/22/medline SP - 343 EP - 350 JF - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES JO - Ulus Travma Acil Cerrahi Derg VL - 26 IS - 3 N2 - BACKGROUND: Management of the skin degloving injuries is still a problematic issue, and the avulsed part of the skin may become necrotic. We hypothesized that the anticoagulant pharmacological agents, fondaparinux and dabigatran may be beneficial in the treatment of degloving injuries by enhancing the viability of the reattached flap. METHODS: Twenty four Wistar rats were divided into three groups as follows: control group (Group 1), fondaparinux group (Group 2) and dabigatran group (Group 3). A model of a degloving injury on the tail of rats was developed in all groups. After 15 minutes, the avulsed flaps were sutured back. Group 1 received 1ml/day saline intraperitoneally for 10 days. Group 2 received 0.3 ml/kg/day fondaparinux intraperitoneally for 10 days. Group 3 received 30 mg/kg/day dabigatran orally for 10 days. At the end of the treatments, gross morphological and histopathological tail tissue survivals were evaluated. RESULTS: Histopathological examination of the fondaparinux and dabigatran groups revealed that the tail skin was mostly viable with mild inflammation. The mean necrotic length in tails and severity of inflammation was significantly higher in the control group compared to the fondaparinux and dabigatran groups (p<0.05). No statistically significant differences were noted between the fondaparinux and dabigatran groups in histopathologic evaluations. There was no significant difference in necrosis lengths and the other histopathological parameters between dabigatran and fondaparinux groups. CONCLUSION: Dabigatran and fondaparinux improved tissue survival in skin degloving injuries concerning gross morphological and histopathological findings. However, the findings of this study should be supported and improved by new experimental and especially clinical studies. SN - 1306-696X UR - https://www.unboundmedicine.com/medline/citation/32436968/Effects_of_dabigatran_and_fondaparinux_on_degloving_injuries:_An_experimental_study_ L2 - http://www.journalagent.com/pubmed/linkout.asp?ISSN=1306-696X&amp;PMID=32436968 DB - PRIME DP - Unbound Medicine ER -
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