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Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study.
Head Neck. 2020 Jul; 42(7):1560-1569.HN

Abstract

BACKGROUND

Objective data on chemosensitive disorders during COVID-19 are lacking in the Literature.

METHODS

Multicenter cohort study that involved four Italian hospitals. Three hundred and forty-five COVID-19 patients underwent objective chemosensitive evaluation.

RESULTS

Chemosensitive disorders self-reported by 256 patients (74.2%) but the 30.1% of the 89 patients who did not report dysfunctions proved objectively hyposmic. Twenty-five percentage of patients were seen serious long-lasting complaints. All asymptomatic patients had a slight lowering of the olfactory threshold. No significant correlations were found between the presence and severity of chemosensitive disorders and the severity of the clinical course. On the contrary, there is a significant correlation between the duration of the olfactory and gustatory symptoms and the development of severe COVID-19.

CONCLUSIONS

Patients under-report the frequency of chemosensitive disorders. Contrary to recent reports, such objective testing refutes the proposal that the presence of olfactory and gustatory dysfunction may predict a milder course, but instead suggests that those with more severe disease neglect such symptoms in the setting of severe respiratory disease.

Authors+Show Affiliations

Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Sassari, Italy.King's College, London, UK.Maxillofacial Surgery Unit, University Hospital of Naples "Federico II", Naples, Italy.Maxillofacial Surgery Operative Unit; Bellaria and Maggiore Hospital, AUSL, Bologna, Italy.Otolaryngology Operative Unit, University Hospital of Sassari, Sassari, Italy.Maxillofacial Surgery Department, San Paolo Hospital, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.Maxillofacial Surgery Department, San Paolo Hospital, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.Otolaryngology Operative Unit, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy.Otolaryngology Operative Unit, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy.Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.Infectious Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Infectious Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Otolaryngology Operative Unit, University Hospital of Sassari, Sassari, Italy.Respiratory Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Respiratory Diseases Operative Unit, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Salerno, Italy.Surveillance and Prevention Department, University Hospital of Sassari, Sassari, Italy.Otolaryngology Operative Unit, University Hospital of Sassari, Sassari, Italy.Infectious Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Infectious Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Respiratory Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Respiratory Diseases Operative Unit, University Hospital of Sassari, Sassari, Italy.Otolaryngology Operative Unit, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, Baronissi, Salerno, Italy.University of Turin, Turin, Italy.Maxillofacial Surgery Department, San Paolo Hospital, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Sassari, Italy.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

32437022

Citation

Vaira, Luigi Angelo, et al. "Olfactory and Gustatory Function Impairment in COVID-19 Patients: Italian Objective Multicenter-study." Head & Neck, vol. 42, no. 7, 2020, pp. 1560-1569.
Vaira LA, Hopkins C, Salzano G, et al. Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head Neck. 2020;42(7):1560-1569.
Vaira, L. A., Hopkins, C., Salzano, G., Petrocelli, M., Melis, A., Cucurullo, M., Ferrari, M., Gagliardini, L., Pipolo, C., Deiana, G., Fiore, V., De Vito, A., Turra, N., Canu, S., Maglio, A., Serra, A., Bussu, F., Madeddu, G., Babudieri, S., ... De Riu, G. (2020). Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. Head & Neck, 42(7), 1560-1569. https://doi.org/10.1002/hed.26269
Vaira LA, et al. Olfactory and Gustatory Function Impairment in COVID-19 Patients: Italian Objective Multicenter-study. Head Neck. 2020;42(7):1560-1569. PubMed PMID: 32437022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study. AU - Vaira,Luigi Angelo, AU - Hopkins,Claire, AU - Salzano,Giovanni, AU - Petrocelli,Marzia, AU - Melis,Andrea, AU - Cucurullo,Marco, AU - Ferrari,Mario, AU - Gagliardini,Laura, AU - Pipolo,Carlotta, AU - Deiana,Giovanna, AU - Fiore,Vito, AU - De Vito,Andrea, AU - Turra,Nicola, AU - Canu,Sara, AU - Maglio,Angelantonio, AU - Serra,Antonello, AU - Bussu,Francesco, AU - Madeddu,Giordano, AU - Babudieri,Sergio, AU - Giuseppe Fois,Alessandro, AU - Pirina,Pietro, AU - Salzano,Francesco A, AU - De Riu,Pierluigi, AU - Biglioli,Federico, AU - De Riu,Giacomo, Y1 - 2020/05/21/ PY - 2020/04/30/received PY - 2020/05/04/accepted PY - 2020/5/22/pubmed PY - 2020/7/21/medline PY - 2020/5/22/entrez KW - COVID-19 KW - ageusia KW - anosmia KW - smell KW - taste SP - 1560 EP - 1569 JF - Head & neck JO - Head Neck VL - 42 IS - 7 N2 - BACKGROUND: Objective data on chemosensitive disorders during COVID-19 are lacking in the Literature. METHODS: Multicenter cohort study that involved four Italian hospitals. Three hundred and forty-five COVID-19 patients underwent objective chemosensitive evaluation. RESULTS: Chemosensitive disorders self-reported by 256 patients (74.2%) but the 30.1% of the 89 patients who did not report dysfunctions proved objectively hyposmic. Twenty-five percentage of patients were seen serious long-lasting complaints. All asymptomatic patients had a slight lowering of the olfactory threshold. No significant correlations were found between the presence and severity of chemosensitive disorders and the severity of the clinical course. On the contrary, there is a significant correlation between the duration of the olfactory and gustatory symptoms and the development of severe COVID-19. CONCLUSIONS: Patients under-report the frequency of chemosensitive disorders. Contrary to recent reports, such objective testing refutes the proposal that the presence of olfactory and gustatory dysfunction may predict a milder course, but instead suggests that those with more severe disease neglect such symptoms in the setting of severe respiratory disease. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/32437022/Olfactory_and_gustatory_function_impairment_in_COVID_19_patients:_Italian_objective_multicenter_study_ L2 - https://doi.org/10.1002/hed.26269 DB - PRIME DP - Unbound Medicine ER -