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Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients.
Head Neck. 2020 Jul; 42(7):1583-1590.HN

Abstract

OBJECTIVE

To investigate olfactory dysfunction (OD) in patients with mild coronavirus disease 2019 (COVID-19) through patient-reported outcome questionnaires and objective psychophysical testing.

METHODS

COVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome-22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey. Objective OD was evaluated using psychophysical tests.

RESULTS

Eighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip.

CONCLUSION

A significant proportion of COVID-19 patients reporting OD do not have OD on objective testing.

Authors+Show Affiliations

COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France. Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Neurology, CHU de Charleroi, Charleroi, Belgium.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Otorhinolaryngology-Head and Neck Surgery, Hospital Universitario Donostia, San Sebastian, Spain.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Head and Neck Surgery, EpiCURA Hospital, Belgium.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Otolaryngology-Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Brussels, Belgium. Department of Dean, Faculté de Médecine et Pharmacie, Université de Mons (UMONS), Mons, Belgium.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium.COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Marseille, France. Department of Otolaryngology-Head and Neck Surgery, University of Western Ontario, London, Ontario, Canada.Department of Human Anatomy and Experimental Oncology, Faculty of Medicine, UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Bruxelles, CHU Saint-Pierre, School of Medicine, Université Libre de Bruxelles, Brussels, Belgium. Department of Head and Neck Surgery, EpiCURA Hospital, Belgium.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32437033

Citation

Lechien, Jerome R., et al. "Objective Olfactory Evaluation of Self-reported Loss of Smell in a Case Series of 86 COVID-19 Patients." Head & Neck, vol. 42, no. 7, 2020, pp. 1583-1590.
Lechien JR, Cabaraux P, Chiesa-Estomba CM, et al. Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients. Head Neck. 2020;42(7):1583-1590.
Lechien, J. R., Cabaraux, P., Chiesa-Estomba, C. M., Khalife, M., Hans, S., Calvo-Henriquez, C., Martiny, D., Journe, F., Sowerby, L., & Saussez, S. (2020). Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients. Head & Neck, 42(7), 1583-1590. https://doi.org/10.1002/hed.26279
Lechien JR, et al. Objective Olfactory Evaluation of Self-reported Loss of Smell in a Case Series of 86 COVID-19 Patients. Head Neck. 2020;42(7):1583-1590. PubMed PMID: 32437033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Objective olfactory evaluation of self-reported loss of smell in a case series of 86 COVID-19 patients. AU - Lechien,Jerome R, AU - Cabaraux,Pierre, AU - Chiesa-Estomba,Carlos M, AU - Khalife,Mohamad, AU - Hans,Stéphane, AU - Calvo-Henriquez,Christian, AU - Martiny,Delphine, AU - Journe,Fabrice, AU - Sowerby,Leigh, AU - Saussez,Sven, Y1 - 2020/05/21/ PY - 2020/05/02/received PY - 2020/05/06/accepted PY - 2020/5/22/pubmed PY - 2020/7/21/medline PY - 2020/5/22/entrez KW - COVID-19 KW - anosmia KW - coronavirus KW - evaluation KW - olfaction KW - olfactory KW - smell KW - taste SP - 1583 EP - 1590 JF - Head & neck JO - Head Neck VL - 42 IS - 7 N2 - OBJECTIVE: To investigate olfactory dysfunction (OD) in patients with mild coronavirus disease 2019 (COVID-19) through patient-reported outcome questionnaires and objective psychophysical testing. METHODS: COVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome-22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey. Objective OD was evaluated using psychophysical tests. RESULTS: Eighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip. CONCLUSION: A significant proportion of COVID-19 patients reporting OD do not have OD on objective testing. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/32437033/Objective_olfactory_evaluation_of_self_reported_loss_of_smell_in_a_case_series_of_86_COVID_19_patients_ L2 - https://doi.org/10.1002/hed.26279 DB - PRIME DP - Unbound Medicine ER -