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Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man.
J Clin Pharmacol. 1988 Dec; 28(12):1136-40.JC

Abstract

We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten subjects following 500 mg oral ingestion of each product. Nicotinuric acid is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid. Although both products demonstrated controlled release profiles, the rate of appearance of nicotinic and nicotinuric acid in the urine as well as the rate of in vitro drug dissolution of the Bronson product were more rapid compared with Nicobid. Moreover, the total amounts of nicotinic acid and nicotinuric acid recovered in the urine after 24 hours were greater for the Bronson product (P less than .05). Since sustained presentation of nicotinic acid to the liver may correlate with clinical antihyperlipidemic effects, our results suggest that the Bronson product may prove to be a clinically useful preparation.

Authors+Show Affiliations

Department of Pharmacy, Brigham and Women's Hospital, Boston, Massachusetts.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3243933

Citation

Figge, H L., et al. "Comparison of Excretion of Nicotinuric Acid After Ingestion of Two Controlled Release Nicotinic Acid Preparations in Man." Journal of Clinical Pharmacology, vol. 28, no. 12, 1988, pp. 1136-40.
Figge HL, Figge J, Souney PF, et al. Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man. J Clin Pharmacol. 1988;28(12):1136-40.
Figge, H. L., Figge, J., Souney, P. F., Sacks, F. M., Shargel, L., Janosik, J. E., & Kaul, A. F. (1988). Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man. Journal of Clinical Pharmacology, 28(12), 1136-40.
Figge HL, et al. Comparison of Excretion of Nicotinuric Acid After Ingestion of Two Controlled Release Nicotinic Acid Preparations in Man. J Clin Pharmacol. 1988;28(12):1136-40. PubMed PMID: 3243933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of excretion of nicotinuric acid after ingestion of two controlled release nicotinic acid preparations in man. AU - Figge,H L, AU - Figge,J, AU - Souney,P F, AU - Sacks,F M, AU - Shargel,L, AU - Janosik,J E, AU - Kaul,A F, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 1136 EP - 40 JF - Journal of clinical pharmacology JO - J Clin Pharmacol VL - 28 IS - 12 N2 - We tested an inexpensive controlled-release nicotinic acid product (Bronson Pharmaceuticals, LaCanada, CA) and compared it with the standard, more expensive, controlled release product, Nicobid (Rorer Pharmaceuticals), by measuring the 24 hour urinary recovery of nicotinic and nicotinuric acids from ten subjects following 500 mg oral ingestion of each product. Nicotinuric acid is the major detoxification product of nicotinic acid and may serve as a simple quantitative index of hepatic biotransformation of nicotinic acid. Although both products demonstrated controlled release profiles, the rate of appearance of nicotinic and nicotinuric acid in the urine as well as the rate of in vitro drug dissolution of the Bronson product were more rapid compared with Nicobid. Moreover, the total amounts of nicotinic acid and nicotinuric acid recovered in the urine after 24 hours were greater for the Bronson product (P less than .05). Since sustained presentation of nicotinic acid to the liver may correlate with clinical antihyperlipidemic effects, our results suggest that the Bronson product may prove to be a clinically useful preparation. SN - 0091-2700 UR - https://www.unboundmedicine.com/medline/citation/3243933/Comparison_of_excretion_of_nicotinuric_acid_after_ingestion_of_two_controlled_release_nicotinic_acid_preparations_in_man_ DB - PRIME DP - Unbound Medicine ER -