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Advancement in nanogel formulations provides controlled drug release.
Int J Pharm. 2020 Jun 30; 584:119435.IJ

Abstract

Nanogels are currently considered as promising nanosized drug delivery carriers. Nanogels are made of a crosslinked polymeric network which could encapsulate both hydrophilic and hydrophobic drugs due to their tunable nature. The ability of nanogels to control drug release is vastly described in the literature and researchers are consistently improving the control of drug release from nanogel by designing new polymers having specific sensitivity to a chemical or physical stimulus. In this review, we briefly discuss the definition of nanogels, their release profiles, their specific gel-based characteristics and the pathways of dug release from nanogels. We have focused on the stimuli responsive nanogels and their release profile. This compilation opens the window for understanding the influence of chemical composition and design of various nanogel on their release in the presence and absence of corresponding stimuli such as temperature, pH, enzymes and others. The uniqueness of this review is that it highlights the data of release profiles in terms of the different nanogel composition and triggers. It also points the high potential of nanogels in the list of candidates for drug delivery systems, thanks to their properties regarding drug encapsulation and release, combined advantages of nano-size and swelling characteristics of hydrogel.

Authors+Show Affiliations

Université de Paris, UTCBS (Chemical and Biological Technologies for Health Group), CNRS, INSERM, Faculté de Pharmacie, 75006 Paris, France.Université de Paris, UTCBS (Chemical and Biological Technologies for Health Group), CNRS, INSERM, Faculté de Pharmacie, 75006 Paris, France.Université de Paris, UTCBS (Chemical and Biological Technologies for Health Group), CNRS, INSERM, Faculté de Pharmacie, 75006 Paris, France. Electronic address: Nathalie.Mignet@parisdescartes.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32439585

Citation

Ahmed, Shayan, et al. "Advancement in Nanogel Formulations Provides Controlled Drug Release." International Journal of Pharmaceutics, vol. 584, 2020, p. 119435.
Ahmed S, Alhareth K, Mignet N. Advancement in nanogel formulations provides controlled drug release. Int J Pharm. 2020;584:119435.
Ahmed, S., Alhareth, K., & Mignet, N. (2020). Advancement in nanogel formulations provides controlled drug release. International Journal of Pharmaceutics, 584, 119435. https://doi.org/10.1016/j.ijpharm.2020.119435
Ahmed S, Alhareth K, Mignet N. Advancement in Nanogel Formulations Provides Controlled Drug Release. Int J Pharm. 2020 Jun 30;584:119435. PubMed PMID: 32439585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advancement in nanogel formulations provides controlled drug release. AU - Ahmed,Shayan, AU - Alhareth,Khair, AU - Mignet,Nathalie, Y1 - 2020/05/19/ PY - 2020/01/10/received PY - 2020/04/23/revised PY - 2020/05/13/accepted PY - 2020/5/23/pubmed PY - 2020/5/23/medline PY - 2020/5/23/entrez KW - Controlled release KW - Crosslinked polymeric network KW - Drug delivery systems KW - Hydrogel KW - Nanogel KW - Triggered release SP - 119435 EP - 119435 JF - International journal of pharmaceutics JO - Int J Pharm VL - 584 N2 - Nanogels are currently considered as promising nanosized drug delivery carriers. Nanogels are made of a crosslinked polymeric network which could encapsulate both hydrophilic and hydrophobic drugs due to their tunable nature. The ability of nanogels to control drug release is vastly described in the literature and researchers are consistently improving the control of drug release from nanogel by designing new polymers having specific sensitivity to a chemical or physical stimulus. In this review, we briefly discuss the definition of nanogels, their release profiles, their specific gel-based characteristics and the pathways of dug release from nanogels. We have focused on the stimuli responsive nanogels and their release profile. This compilation opens the window for understanding the influence of chemical composition and design of various nanogel on their release in the presence and absence of corresponding stimuli such as temperature, pH, enzymes and others. The uniqueness of this review is that it highlights the data of release profiles in terms of the different nanogel composition and triggers. It also points the high potential of nanogels in the list of candidates for drug delivery systems, thanks to their properties regarding drug encapsulation and release, combined advantages of nano-size and swelling characteristics of hydrogel. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/32439585/Advancement_in_nanogel_formulations_provides_controlled_drug_release_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(20)30419-1 DB - PRIME DP - Unbound Medicine ER -
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