Advancement in nanogel formulations provides controlled drug release.Int J Pharm. 2020 Jun 30; 584:119435.IJ
Nanogels are currently considered as promising nanosized drug delivery carriers. Nanogels are made of a crosslinked polymeric network which could encapsulate both hydrophilic and hydrophobic drugs due to their tunable nature. The ability of nanogels to control drug release is vastly described in the literature and researchers are consistently improving the control of drug release from nanogel by designing new polymers having specific sensitivity to a chemical or physical stimulus. In this review, we briefly discuss the definition of nanogels, their release profiles, their specific gel-based characteristics and the pathways of dug release from nanogels. We have focused on the stimuli responsive nanogels and their release profile. This compilation opens the window for understanding the influence of chemical composition and design of various nanogel on their release in the presence and absence of corresponding stimuli such as temperature, pH, enzymes and others. The uniqueness of this review is that it highlights the data of release profiles in terms of the different nanogel composition and triggers. It also points the high potential of nanogels in the list of candidates for drug delivery systems, thanks to their properties regarding drug encapsulation and release, combined advantages of nano-size and swelling characteristics of hydrogel.