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Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function.
Naunyn Schmiedebergs Arch Pharmacol. 2020 10; 393(10):1911-1920.NS

Abstract

In the modern world, indiscriminate human activities impelled environmental toxicity through heavy metals such as cadmium (Cd) that poses significant health hazards to the flora and fauna. Multiple mechanisms such as oxidative stress, inflammation, apoptotic cell death, and chromosomal aberrations underlie the Cd-induced organ toxicity with the liver and kidneys bearing most of the brunt. Fumaric acid (FA) is an organic acid (C4H4O4) omnipresent in nature and attributed with such properties (e.g., antioxidant, anti-inflammatory, analgesic, chemopreventive, anti-psoriatic, immunomodulatory, and neuroprotective) that may bestow relief in Cd-induced liver damage. Hence, in the present study, the protective effects of FA were determined in Cd-induced hepatotoxicity in rats. Wistar rats were chronically exposed to Cd (5 mg/kg, p.o.) to induce liver dysfunction. The rats were subjected to FA (1.25, 2.5, 5 mg/kg; p.o.) pre-treatment for 28 days to observe effects on liver and serum biomarkers of oxidative stress, enzymatic activities, and hepatic damage (liver histopathology). Body weights, feed/water intake, body mass index (BMI), and non-invasive parameters (FIB-4 score; AST/ALT ratio) were quantified. Cd-triggered hepatic injury in rats through oxidative stress, derangement of hepatic serum biomarkers (ALT, AST, ALP, LDH, bilirubin, cholesterol, triglycerides, uric acid, and platelet count), and pathogenic alteration in non-invasive parameters. FA pre-treatment significantly protected rat livers against Cd toxicity by decreasing oxidative stress and improving the hepatic serum biomarkers and non-invasive parameters. In a histopathological analysis, FA prevented Cd-accrued hepatocellular damage. Fumaric acid showed potential to avert hepatic injury against cadmium in rats. Graphical abstract.

Authors+Show Affiliations

Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, 140111, India.Department of Biomedical Sciences, College of Pharmacy, Shaqra University, Al Dawadmi, Kingdom of Saudi Arabia.Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai Rajpura, Patiala, Punjab, 140401, India.Department of Pharmacology, Amar Shaheed Baba Ajit Singh Jujhar Singh Memorial College of Pharmacy, Bela, Ropar, Punjab, 140111, India. kushwah_ph05@yahoo.co.in.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32440768

Citation

Kaur, Gurpreet, et al. "Fumaric Acid Protect the Cadmium-induced Hepatotoxicity in Rats: Owing to Its Antioxidant, Anti-inflammatory Action and Aid in Recast the Liver Function." Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 393, no. 10, 2020, pp. 1911-1920.
Kaur G, Shivanandappa TB, Kumar M, et al. Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(10):1911-1920.
Kaur, G., Shivanandappa, T. B., Kumar, M., & Kushwah, A. S. (2020). Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function. Naunyn-Schmiedeberg's Archives of Pharmacology, 393(10), 1911-1920. https://doi.org/10.1007/s00210-020-01900-7
Kaur G, et al. Fumaric Acid Protect the Cadmium-induced Hepatotoxicity in Rats: Owing to Its Antioxidant, Anti-inflammatory Action and Aid in Recast the Liver Function. Naunyn Schmiedebergs Arch Pharmacol. 2020;393(10):1911-1920. PubMed PMID: 32440768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fumaric acid protect the cadmium-induced hepatotoxicity in rats: owing to its antioxidant, anti-inflammatory action and aid in recast the liver function. AU - Kaur,Gurpreet, AU - Shivanandappa,Thippeswamy Boreddy, AU - Kumar,Manish, AU - Kushwah,Ajay Singh, Y1 - 2020/05/21/ PY - 2020/02/19/received PY - 2020/05/08/accepted PY - 2020/5/23/pubmed PY - 2021/8/12/medline PY - 2020/5/23/entrez KW - Cadmium KW - Fumaric acid KW - Hepatotoxicity KW - Oxidative stress SP - 1911 EP - 1920 JF - Naunyn-Schmiedeberg's archives of pharmacology JO - Naunyn Schmiedebergs Arch Pharmacol VL - 393 IS - 10 N2 - In the modern world, indiscriminate human activities impelled environmental toxicity through heavy metals such as cadmium (Cd) that poses significant health hazards to the flora and fauna. Multiple mechanisms such as oxidative stress, inflammation, apoptotic cell death, and chromosomal aberrations underlie the Cd-induced organ toxicity with the liver and kidneys bearing most of the brunt. Fumaric acid (FA) is an organic acid (C4H4O4) omnipresent in nature and attributed with such properties (e.g., antioxidant, anti-inflammatory, analgesic, chemopreventive, anti-psoriatic, immunomodulatory, and neuroprotective) that may bestow relief in Cd-induced liver damage. Hence, in the present study, the protective effects of FA were determined in Cd-induced hepatotoxicity in rats. Wistar rats were chronically exposed to Cd (5 mg/kg, p.o.) to induce liver dysfunction. The rats were subjected to FA (1.25, 2.5, 5 mg/kg; p.o.) pre-treatment for 28 days to observe effects on liver and serum biomarkers of oxidative stress, enzymatic activities, and hepatic damage (liver histopathology). Body weights, feed/water intake, body mass index (BMI), and non-invasive parameters (FIB-4 score; AST/ALT ratio) were quantified. Cd-triggered hepatic injury in rats through oxidative stress, derangement of hepatic serum biomarkers (ALT, AST, ALP, LDH, bilirubin, cholesterol, triglycerides, uric acid, and platelet count), and pathogenic alteration in non-invasive parameters. FA pre-treatment significantly protected rat livers against Cd toxicity by decreasing oxidative stress and improving the hepatic serum biomarkers and non-invasive parameters. In a histopathological analysis, FA prevented Cd-accrued hepatocellular damage. Fumaric acid showed potential to avert hepatic injury against cadmium in rats. Graphical abstract. SN - 1432-1912 UR - https://www.unboundmedicine.com/medline/citation/32440768/Fumaric_acid_protect_the_cadmium_induced_hepatotoxicity_in_rats:_owing_to_its_antioxidant_anti_inflammatory_action_and_aid_in_recast_the_liver_function_ L2 - https://dx.doi.org/10.1007/s00210-020-01900-7 DB - PRIME DP - Unbound Medicine ER -