Tags

Type your tag names separated by a space and hit enter

The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution.
Hum Reprod Update. 2020 Jun 18; 26(4):453-473.HR

Abstract

Following early studies showing no adverse effects, cleavage stage biopsy by zona drilling using acid Tyrode's solution, and removal of single blastomeres for preimplantation genetic testing (PGT) and identification of sex in couples at risk of X-linked disease, was performed by Handyside and colleagues in late 1989, and pregnancies reported in 1990. This method was later used for specific diagnosis of monogenic conditions, and a few years later also for chromosomal structural and/or numerical impairments, thereby establishing a valuable alternative option to prenatal diagnosis. This revolutionary approach in clinical embryology spread worldwide, and several other embryo biopsy strategies developed over three decades in a process that is still ongoing. The rationale of this narrative review is to outline the different biopsy approaches implemented across the years in the workflow of the IVF clinics that provided PGT: their establishment, the first clinical experiences, their downsides, evolution, improvement and standardization. The history ends with a glimpse of the future: minimally/non-invasive PGT and experimental embryo micromanipulation protocols. This grand theme review outlines a timeline of the evolution of embryo biopsy protocols, whose implementation is increasing worldwide together with the increasing application of PGT techniques in IVF. It represents a vade mecum especially for the past, present and upcoming operators and experts in this field to (re)live this history from its dawn to its most likely future.

Authors+Show Affiliations

Clinica Valle Giulia, Genera Center for Reproductive Medicine, Rome, Italy.Clinica Valle Giulia, Genera Center for Reproductive Medicine, Rome, Italy.Igenomix Italy, Marostica, Italy. Dipartimento di Scienze Anatomiche, Istologiche, Medico Legali e dell'Apparato Locomotore, Sezione Istologia ed Embriologia Medica, University of Rome 'Sapienza', Rome, Italy.R&D Department, Igenomix and Incliva, Valencia, Spain.Clinica Valle Giulia, Genera Center for Reproductive Medicine, Rome, Italy.R&D Department, Igenomix and Incliva, Valencia, Spain.Clinica Valle Giulia, Genera Center for Reproductive Medicine, Rome, Italy.School of Biosciences, University of Kent, Canterbury, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32441746

Citation

Cimadomo, Danilo, et al. "The Dawn of the Future: 30 Years From the First Biopsy of a Human Embryo. the Detailed History of an Ongoing Revolution." Human Reproduction Update, vol. 26, no. 4, 2020, pp. 453-473.
Cimadomo D, Rienzi L, Capalbo A, et al. The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. Hum Reprod Update. 2020;26(4):453-473.
Cimadomo, D., Rienzi, L., Capalbo, A., Rubio, C., Innocenti, F., García-Pascual, C. M., Ubaldi, F. M., & Handyside, A. (2020). The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. Human Reproduction Update, 26(4), 453-473. https://doi.org/10.1093/humupd/dmaa019
Cimadomo D, et al. The Dawn of the Future: 30 Years From the First Biopsy of a Human Embryo. the Detailed History of an Ongoing Revolution. Hum Reprod Update. 2020 Jun 18;26(4):453-473. PubMed PMID: 32441746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The dawn of the future: 30 years from the first biopsy of a human embryo. The detailed history of an ongoing revolution. AU - Cimadomo,Danilo, AU - Rienzi,Laura, AU - Capalbo,Antonio, AU - Rubio,Carmen, AU - Innocenti,Federica, AU - García-Pascual,Carmen María, AU - Ubaldi,Filippo Maria, AU - Handyside,Alan, PY - 2019/11/30/received PY - 2020/03/25/revised PY - 2020/5/23/pubmed PY - 2020/5/23/medline PY - 2020/5/23/entrez KW - IVF KW - blastocyst KW - blastomere biopsy KW - embryo KW - history of PGT KW - micromanipulation KW - oocyte KW - polar body biopsy KW - preimplantation genetic testing KW - trophectoderm biopsy SP - 453 EP - 473 JF - Human reproduction update JO - Hum. Reprod. Update VL - 26 IS - 4 N2 - Following early studies showing no adverse effects, cleavage stage biopsy by zona drilling using acid Tyrode's solution, and removal of single blastomeres for preimplantation genetic testing (PGT) and identification of sex in couples at risk of X-linked disease, was performed by Handyside and colleagues in late 1989, and pregnancies reported in 1990. This method was later used for specific diagnosis of monogenic conditions, and a few years later also for chromosomal structural and/or numerical impairments, thereby establishing a valuable alternative option to prenatal diagnosis. This revolutionary approach in clinical embryology spread worldwide, and several other embryo biopsy strategies developed over three decades in a process that is still ongoing. The rationale of this narrative review is to outline the different biopsy approaches implemented across the years in the workflow of the IVF clinics that provided PGT: their establishment, the first clinical experiences, their downsides, evolution, improvement and standardization. The history ends with a glimpse of the future: minimally/non-invasive PGT and experimental embryo micromanipulation protocols. This grand theme review outlines a timeline of the evolution of embryo biopsy protocols, whose implementation is increasing worldwide together with the increasing application of PGT techniques in IVF. It represents a vade mecum especially for the past, present and upcoming operators and experts in this field to (re)live this history from its dawn to its most likely future. SN - 1460-2369 UR - https://www.unboundmedicine.com/medline/citation/32441746/The_dawn_of_the_future:_30_years_from_the_first_biopsy_of_a_human_embryo._The_detailed_history_of_an_ongoing_revolution L2 - https://academic.oup.com/humupd/article-lookup/doi/10.1093/humupd/dmaa019 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.