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The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells.
Virology. 2020 08; 547:7-11.V

Abstract

SARS-COV-2 has recently emerged as a new public health threat. Herein, we report that the FDA-approved drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro molar concentration. Treatment of cells with auranofin resulted in a 95% reduction in the viral RNA at 48 h after infection. Auranofin treatment dramatically reduced the expression of SARS-COV-2-induced cytokines in human cells. These data indicate that auranofin could be a useful drug to limit SARS-CoV-2 infection and associated lung injury due to its antiviral, anti-inflammatory and anti-reactive oxygen species (ROS) properties. Further animal studies are warranted to evaluate the safety and efficacy of auranofin for the management of SARS-COV-2 associated disease.

Authors+Show Affiliations

Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, 30303, Georgia. Electronic address: hrothan@gsu.edu.Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, 30303, Georgia.Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, 30303, Georgia.Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, 30303, Georgia.Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, 30303, Georgia.Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, 30303, Georgia. Electronic address: mkumar8@gsu.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32442105

Citation

Rothan, Hussin A., et al. "The FDA-approved Gold Drug Auranofin Inhibits Novel Coronavirus (SARS-COV-2) Replication and Attenuates Inflammation in Human Cells." Virology, vol. 547, 2020, pp. 7-11.
Rothan HA, Stone S, Natekar J, et al. The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells. Virology. 2020;547:7-11.
Rothan, H. A., Stone, S., Natekar, J., Kumari, P., Arora, K., & Kumar, M. (2020). The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells. Virology, 547, 7-11. https://doi.org/10.1016/j.virol.2020.05.002
Rothan HA, et al. The FDA-approved Gold Drug Auranofin Inhibits Novel Coronavirus (SARS-COV-2) Replication and Attenuates Inflammation in Human Cells. Virology. 2020;547:7-11. PubMed PMID: 32442105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells. AU - Rothan,Hussin A, AU - Stone,Shannon, AU - Natekar,Janhavi, AU - Kumari,Pratima, AU - Arora,Komal, AU - Kumar,Mukesh, Y1 - 2020/05/19/ PY - 2020/04/11/received PY - 2020/05/03/revised PY - 2020/05/05/accepted PY - 2020/5/23/pubmed PY - 2020/6/26/medline PY - 2020/5/23/entrez KW - Anti-inflammatory KW - Antiviral KW - Auranofin KW - COVID-19 KW - SARS-COV-2 SP - 7 EP - 11 JF - Virology JO - Virology VL - 547 N2 - SARS-COV-2 has recently emerged as a new public health threat. Herein, we report that the FDA-approved drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro molar concentration. Treatment of cells with auranofin resulted in a 95% reduction in the viral RNA at 48 h after infection. Auranofin treatment dramatically reduced the expression of SARS-COV-2-induced cytokines in human cells. These data indicate that auranofin could be a useful drug to limit SARS-CoV-2 infection and associated lung injury due to its antiviral, anti-inflammatory and anti-reactive oxygen species (ROS) properties. Further animal studies are warranted to evaluate the safety and efficacy of auranofin for the management of SARS-COV-2 associated disease. SN - 1096-0341 UR - https://www.unboundmedicine.com/medline/citation/32442105/The_FDA-approved_gold_drug_auranofin_inhibits_novel_coronavirus_(SARS-COV-2)_replication_and_attenuates_inflammation_in_human_cells L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(20)30081-7 DB - PRIME DP - Unbound Medicine ER -