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Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control.
Eye Contact Lens. 2020 May 14 [Online ahead of print]EC

Abstract

OBJECTIVE

To compare the efficacies of 0.02% atropine eye drops and orthokeratology to control axial length (AL) elongation in children with myopia.

METHODS

In this historical control study, 247 children with myopia whose administration of 0.02% atropine (n=142) or underwent orthokeratology from an earlier study (n=105, control group) were enrolled. Data on AL and other baseline parameters were recorded at baseline and after 1 and 2 years of treatment.

RESULTS

The mean changes in AL in the first and second years of treatment were 0.30±0.21 and 0.28±0.20 mm, respectively, in the 0.02% atropine group and 0.16±0.20 and 0.20±0.16 mm, respectively, in the orthokeratology group. Axial length elongations after 2 years of treatment were 0.58±0.35 and 0.36±0.30 mm (P=0.007) in the 0.02% atropine and orthokeratology groups, respectively. Multivariate regression analyses showed that the AL elongation was significantly faster in the 0.02% atropine group than in the orthokeratology group (β=0.18, P=0.009). In multivariate regression analyses, younger age and shorter baseline AL were associated with a rapid AL elongation in the 0.02% atropine group (βage=-0.04, P=0.01; βAL=-0.17, P=0.03), while younger age, lower baseline spherical equivalent refractive error (SER), and shorter baseline AL were associated with a greater increase in AL in the orthokeratology group (βage=-0.03, P=0.04; βSER=0.06, P=0.03; βAL=-0.11, P=0.009). Faster AL elongation was found in the 0.02% atropine group compared with the orthokeratology group at higher baseline SER (P=0.04, interaction test).

CONCLUSION

Within the limits of this study design, orthokeratology seems to be a better method for controlling AL elongation compared with administration of 0.02% atropine in children with higher myopia over a treatment period of 2 years.

Authors+Show Affiliations

Ophthalmology, The First Affiliated Hospital of Zhengzhou University (Y.L., A.-C.F., W.-Q.W., L.W., B.-X.Z.), Zhengzhou, China; Ophthalmology, The Affiliated Eye Hospital of Suzhou Vocational Health College (N.J.), Suzhou, China; and Ophthalmology, Provincial People's Hospital (J.Q.), Henan Eye Hospital, Zhengzhou, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32443010

Citation

Lyu, Yong, et al. "Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control." Eye & Contact Lens, 2020.
Lyu Y, Ji N, Fu AC, et al. Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control. Eye Contact Lens. 2020.
Lyu, Y., Ji, N., Fu, A. C., Wang, W. Q., Wei, L., Qin, J., & Zhao, B. X. (2020). Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control. Eye & Contact Lens. https://doi.org/10.1097/ICL.0000000000000699
Lyu Y, et al. Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control. Eye Contact Lens. 2020 May 14; PubMed PMID: 32443010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Administration of 0.02% Atropine and Orthokeratology for Myopia Control. AU - Lyu,Yong, AU - Ji,Na, AU - Fu,Ai-Cun, AU - Wang,Wei-Qun, AU - Wei,Li, AU - Qin,Jian, AU - Zhao,Bing-Xin, Y1 - 2020/05/14/ PY - 2020/5/23/entrez PY - 2020/5/23/pubmed PY - 2020/5/23/medline JF - Eye & contact lens JO - Eye Contact Lens N2 - OBJECTIVE: To compare the efficacies of 0.02% atropine eye drops and orthokeratology to control axial length (AL) elongation in children with myopia. METHODS: In this historical control study, 247 children with myopia whose administration of 0.02% atropine (n=142) or underwent orthokeratology from an earlier study (n=105, control group) were enrolled. Data on AL and other baseline parameters were recorded at baseline and after 1 and 2 years of treatment. RESULTS: The mean changes in AL in the first and second years of treatment were 0.30±0.21 and 0.28±0.20 mm, respectively, in the 0.02% atropine group and 0.16±0.20 and 0.20±0.16 mm, respectively, in the orthokeratology group. Axial length elongations after 2 years of treatment were 0.58±0.35 and 0.36±0.30 mm (P=0.007) in the 0.02% atropine and orthokeratology groups, respectively. Multivariate regression analyses showed that the AL elongation was significantly faster in the 0.02% atropine group than in the orthokeratology group (β=0.18, P=0.009). In multivariate regression analyses, younger age and shorter baseline AL were associated with a rapid AL elongation in the 0.02% atropine group (βage=-0.04, P=0.01; βAL=-0.17, P=0.03), while younger age, lower baseline spherical equivalent refractive error (SER), and shorter baseline AL were associated with a greater increase in AL in the orthokeratology group (βage=-0.03, P=0.04; βSER=0.06, P=0.03; βAL=-0.11, P=0.009). Faster AL elongation was found in the 0.02% atropine group compared with the orthokeratology group at higher baseline SER (P=0.04, interaction test). CONCLUSION: Within the limits of this study design, orthokeratology seems to be a better method for controlling AL elongation compared with administration of 0.02% atropine in children with higher myopia over a treatment period of 2 years. SN - 1542-233X UR - https://www.unboundmedicine.com/medline/citation/32443010/Comparison_of_Administration_of_0_02_Atropine_and_Orthokeratology_for_Myopia_Control_ L2 - https://doi.org/10.1097/ICL.0000000000000699 DB - PRIME DP - Unbound Medicine ER -
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