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Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets.
Pharmaceuticals (Basel). 2020 May 18; 13(5)P

Abstract

This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies.

Authors+Show Affiliations

Centro Militar de Farmacia de la Defensa, Carretera M-609 de Miraflores, Km 34, Colmenar Viejo, 28770 Madrid, Spain.Unidad Docente de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, E-28871 Madrid, Spain.Unidad Docente de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Alcalá, Alcalá de Henares, E-28871 Madrid, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32443638

Citation

Alejandro, Blasco, et al. "Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets." Pharmaceuticals (Basel, Switzerland), vol. 13, no. 5, 2020.
Alejandro B, Guillermo T, Ángeles PM. Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. Pharmaceuticals (Basel). 2020;13(5).
Alejandro, B., Guillermo, T., & Ángeles, P. M. (2020). Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. Pharmaceuticals (Basel, Switzerland), 13(5). https://doi.org/10.3390/ph13050100
Alejandro B, Guillermo T, Ángeles PM. Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. Pharmaceuticals (Basel). 2020 May 18;13(5) PubMed PMID: 32443638.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and Evaluation of Loperamide HCl Oro Dispersible Tablets. AU - Alejandro,Blasco, AU - Guillermo,Torrado, AU - Ángeles,Peña M, Y1 - 2020/05/18/ PY - 2020/04/18/received PY - 2020/05/08/revised PY - 2020/05/14/accepted PY - 2020/5/24/entrez PY - 2020/5/24/pubmed PY - 2020/5/24/medline KW - loperamide hydrochloride KW - orodispersible tablet KW - physicochemical characterization JF - Pharmaceuticals (Basel, Switzerland) JO - Pharmaceuticals (Basel) VL - 13 IS - 5 N2 - This work proposes the design of novel oral disintegrating tablets (ODTs) of loperamide HCl with special emphasis on disintegration and dissolution studies. The main goal was augmenting the adherence to treatment of diseases which happen with diarrhea in soldiers who are exposed to diverse kinds of hostile environments. Optimized orally disintegrating tablets were prepared by the direct compression method from galenic development to the industrial scale technique, thanks to strategic and support actions between the Spanish Army Force Lab and the Department of Biomedical Sciences (UAH). The results show that loperamide HCl ODT offers a rapid beginning of action and improvement in the bioavailability of poorly absorbed drugs. The manufactured ODTs complied with the pharmacopeia guidelines regarding hardness, weight variation, thickness, friability, drug content, wetting time, percentage of water absorption, disintegration time, and in vitro dissolution profile. Drug compatibility with excipients was checked by DSC, FTIR, and SEM studies. SN - 1424-8247 UR - https://www.unboundmedicine.com/medline/citation/32443638/Formulation_and_Evaluation_of_Loperamide_HCl_Oro_Dispersible_Tablets L2 - https://www.mdpi.com/resolver?pii=ph13050100 DB - PRIME DP - Unbound Medicine ER -
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