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SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease.
J Parkinsons Dis. 2020; 10(3):1023-1031.JP

Abstract

BACKGROUND

α-Synuclein has been related to the pathogenesis of Parkinson's disease (PD), but it has not thoroughly been investigated in idiopathic rapid eye movement sleep behavior disorder (iRBD).

OBJECTIVE

We aimed to explore whether there were different distributions of α-synuclein at a genetic and/or protein level in patients with iRBD.

METHODS

We included 30 patients with iRBD, 30 patients with PD, and 30 age- and sex-matched healthy controls (HCs) in this study. The SNCA methylation and mRNA levels were determined using bisulfite sequencing and quantitative reverse transcription polymerase chain reaction. The plasma levels of exosome α-synuclein were measured using Meso Scale Discovery.

RESULTS

SNCA methylation showed different distribution among HC, iRBD and PD groups (HC vs RBD: p = 0.011; HC vs PD: p < 0.001; RBD vs PD: p = 0.027). However, plasma exosomal α-synuclein levels were only elevated in patients with PD compared to those in HCs (p = 0.027), and were associated with the SNCA methylation only in the PD group (p = 0.030, r = -0.397).

CONCLUSION

SNCA hypomethylation in leukocytes existed both in patients with iRBD and those with PD, indicating that SNCA methylation could be a potential biomarker for early PD diagnosis.

Authors+Show Affiliations

Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China.Department of Neurology, Ruijin Hospital North affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated with the Shanghai Jiao Tong University School of Medicine, Shanghai, China. CAS Center for Excellence in Brain Science and Intelligence Technology, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32444558

Citation

Zhao, Aonan, et al. "SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease." Journal of Parkinson's Disease, vol. 10, no. 3, 2020, pp. 1023-1031.
Zhao A, Li Y, Niu M, et al. SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease. J Parkinsons Dis. 2020;10(3):1023-1031.
Zhao, A., Li, Y., Niu, M., Li, G., Luo, N., Zhou, L., Kang, W., & Liu, J. (2020). SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease. Journal of Parkinson's Disease, 10(3), 1023-1031. https://doi.org/10.3233/JPD-201912
Zhao A, et al. SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease. J Parkinsons Dis. 2020;10(3):1023-1031. PubMed PMID: 32444558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SNCA Hypomethylation in Rapid Eye Movement Sleep Behavior Disorder Is a Potential Biomarker for Parkinson's Disease. AU - Zhao,Aonan, AU - Li,Yuanyuan, AU - Niu,Mengyue, AU - Li,Guanglu, AU - Luo,Ningdi, AU - Zhou,Liche, AU - Kang,Wenyan, AU - Liu,Jun, PY - 2020/5/24/pubmed PY - 2021/9/16/medline PY - 2020/5/24/entrez KW - Parkinson’s disease KW - SNCA hypomethylation KW - biomarker KW - exosome SP - 1023 EP - 1031 JF - Journal of Parkinson's disease JO - J Parkinsons Dis VL - 10 IS - 3 N2 - BACKGROUND: α-Synuclein has been related to the pathogenesis of Parkinson's disease (PD), but it has not thoroughly been investigated in idiopathic rapid eye movement sleep behavior disorder (iRBD). OBJECTIVE: We aimed to explore whether there were different distributions of α-synuclein at a genetic and/or protein level in patients with iRBD. METHODS: We included 30 patients with iRBD, 30 patients with PD, and 30 age- and sex-matched healthy controls (HCs) in this study. The SNCA methylation and mRNA levels were determined using bisulfite sequencing and quantitative reverse transcription polymerase chain reaction. The plasma levels of exosome α-synuclein were measured using Meso Scale Discovery. RESULTS: SNCA methylation showed different distribution among HC, iRBD and PD groups (HC vs RBD: p = 0.011; HC vs PD: p < 0.001; RBD vs PD: p = 0.027). However, plasma exosomal α-synuclein levels were only elevated in patients with PD compared to those in HCs (p = 0.027), and were associated with the SNCA methylation only in the PD group (p = 0.030, r = -0.397). CONCLUSION: SNCA hypomethylation in leukocytes existed both in patients with iRBD and those with PD, indicating that SNCA methylation could be a potential biomarker for early PD diagnosis. SN - 1877-718X UR - https://www.unboundmedicine.com/medline/citation/32444558/SNCA_Hypomethylation_in_Rapid_Eye_Movement_Sleep_Behavior_Disorder_Is_a_Potential_Biomarker_for_Parkinson's_Disease_ L2 - https://content.iospress.com/openurl?genre=article&amp;id=doi:10.3233/JPD-201912 DB - PRIME DP - Unbound Medicine ER -