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A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged with Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography.
Am J Ophthalmol. 2020 09; 217:240-251.AJ

Abstract

PURPOSE

Indocyanine green angiography (ICGA) was compared with swept-source optical coherence tomography angiography (SS-OCTA) for the detection of polypoidal choroidal vasculopathy (PCV).

DESIGN

Retrospective, cross-sectional.

METHODS

Patients with treatment-naïve PCV based on ICGA imaging underwent same-day SS-OCTA imaging at Kyung Hee University Medical Center between April 2017 and November 2018. ICGA and SS-OCTA images were graded independently. SS-OCTA images were graded using both flow and structural information. Images were graded for the number of polypoidal lesions and the total lesion area, which included both the polypoidal lesions and the branching vascular networks (BVNs).

RESULTS

A total of 31 eyes from 30 patients were enrolled. Polypoidal lesions were identified in all eyes using both modalities, and there was agreement on the number of polypoidal lesions in 17 eyes (55%). In 12 eyes (39%), SS-OCTA graders identified a greater number of polypoidal lesions, and in 2 eyes (6%) ICGA graders identified more lesions. There was no significant difference in the lesion area measurements (standard deviation = 1.09, P = .08). The lesion with the largest difference in area measurements resulted from focal areas of atrophy, misdiagnosed as polypoidal lesions on ICGA, and a low-lying serous retinal pigment epithelial detachment erroneously identified as part of the BVN by ICGA graders. SS-OCTA imaging correctly diagnosed the focal areas of atrophy and the serous retinal pigment epitheial detachment.

CONCLUSIONS

SS-OCTA imaging was comparable to ICGA for the diagnosis of treatment-naïve PCV. However, SS-OCTA might be better than ICGA in correctly identifying both polypoidal lesions and BVNs in treatment-naïve PCV.

Authors+Show Affiliations

Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea.Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea.Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea. Electronic address: syyu@khu.ac.kr.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

32445699

Citation

Kim, Kiyoung, et al. "A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged With Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography." American Journal of Ophthalmology, vol. 217, 2020, pp. 240-251.
Kim K, Yang J, Feuer W, et al. A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged with Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography. Am J Ophthalmol. 2020;217:240-251.
Kim, K., Yang, J., Feuer, W., Gregori, G., Kim, E. S., Rosenfeld, P. J., & Yu, S. Y. (2020). A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged with Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography. American Journal of Ophthalmology, 217, 240-251. https://doi.org/10.1016/j.ajo.2020.05.017
Kim K, et al. A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged With Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography. Am J Ophthalmol. 2020;217:240-251. PubMed PMID: 32445699.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged with Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography. AU - Kim,Kiyoung, AU - Yang,Jin, AU - Feuer,William, AU - Gregori,Giovanni, AU - Kim,Eung Suk, AU - Rosenfeld,Philip J, AU - Yu,Seung-Young, Y1 - 2020/05/21/ PY - 2019/12/24/received PY - 2020/05/12/revised PY - 2020/05/13/accepted PY - 2020/5/24/pubmed PY - 2020/10/7/medline PY - 2020/5/24/entrez SP - 240 EP - 251 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 217 N2 - PURPOSE: Indocyanine green angiography (ICGA) was compared with swept-source optical coherence tomography angiography (SS-OCTA) for the detection of polypoidal choroidal vasculopathy (PCV). DESIGN: Retrospective, cross-sectional. METHODS: Patients with treatment-naïve PCV based on ICGA imaging underwent same-day SS-OCTA imaging at Kyung Hee University Medical Center between April 2017 and November 2018. ICGA and SS-OCTA images were graded independently. SS-OCTA images were graded using both flow and structural information. Images were graded for the number of polypoidal lesions and the total lesion area, which included both the polypoidal lesions and the branching vascular networks (BVNs). RESULTS: A total of 31 eyes from 30 patients were enrolled. Polypoidal lesions were identified in all eyes using both modalities, and there was agreement on the number of polypoidal lesions in 17 eyes (55%). In 12 eyes (39%), SS-OCTA graders identified a greater number of polypoidal lesions, and in 2 eyes (6%) ICGA graders identified more lesions. There was no significant difference in the lesion area measurements (standard deviation = 1.09, P = .08). The lesion with the largest difference in area measurements resulted from focal areas of atrophy, misdiagnosed as polypoidal lesions on ICGA, and a low-lying serous retinal pigment epithelial detachment erroneously identified as part of the BVN by ICGA graders. SS-OCTA imaging correctly diagnosed the focal areas of atrophy and the serous retinal pigment epitheial detachment. CONCLUSIONS: SS-OCTA imaging was comparable to ICGA for the diagnosis of treatment-naïve PCV. However, SS-OCTA might be better than ICGA in correctly identifying both polypoidal lesions and BVNs in treatment-naïve PCV. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/32445699/A_Comparison_Study_of_Polypoidal_Choroidal_Vasculopathy_Imaged_with_Indocyanine_Green_Angiography_and_Swept_Source_Optical_Coherence_Tomography_Angiography_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(20)30247-6 DB - PRIME DP - Unbound Medicine ER -