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A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2.
FEBS J. 2020 Sep; 287(17):3633-3650.FJ

Abstract

The emergence of the SARS-CoV-2 strain of the human coronavirus has thrown the world into the midst of a new pandemic. In the human body, the virus causes COVID-19, a disease characterized by shortness of breath, fever, and pneumonia, which can be fatal in vulnerable individuals. SARS-CoV-2 has characteristics of past human coronaviruses, with close genomic similarities to SARS-CoV, the virus that causes the disease SARS. Like these related coronaviruses, SARS-CoV-2 is transmitted through the inhalation of droplets and interaction with contaminated surfaces. Across the world, laboratories are developing candidate vaccines for the virus - with vaccine trials underway in the United States and the United Kingdom - and considering various drugs for possible treatments and prophylaxis. Here, we provide an overview of SARS-CoV-2 by analyzing its virology, epidemiology, and modes of transmission while examining the current progress of testing procedures and possible treatments through drugs and vaccines.

Links

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Authors+Show Affiliations

Atzrodt CL
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Maknojia I
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
McCarthy RDP
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Oldfield TM
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Po J
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Ta KTL
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Stepp HE
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Clements TP
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.

MeSH

Adenosine MonophosphateAlanineAntiviral AgentsCOVID-19COVID-19 TestingCOVID-19 VaccinesCoronavirus InfectionsDrug CombinationsHumansHydroxychloroquineInterferon beta-1aLopinavirMiddle East Respiratory Syndrome CoronavirusPandemicsRespiration, ArtificialRitonavirSevere acute respiratory syndrome-related coronavirusSARS-CoV-2Severe Acute Respiratory SyndromeSeverity of Illness IndexCOVID-19 Drug Treatment

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32446285

Citation

Atzrodt, Cassandra L., et al. "A Guide to COVID-19: a Global Pandemic Caused By the Novel Coronavirus SARS-CoV-2." The FEBS Journal, vol. 287, no. 17, 2020, pp. 3633-3650.
Atzrodt CL, Maknojia I, McCarthy RDP, et al. A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. FEBS J. 2020;287(17):3633-3650.
Atzrodt, C. L., Maknojia, I., McCarthy, R. D. P., Oldfield, T. M., Po, J., Ta, K. T. L., Stepp, H. E., & Clements, T. P. (2020). A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. The FEBS Journal, 287(17), 3633-3650. https://doi.org/10.1111/febs.15375
Atzrodt CL, et al. A Guide to COVID-19: a Global Pandemic Caused By the Novel Coronavirus SARS-CoV-2. FEBS J. 2020;287(17):3633-3650. PubMed PMID: 32446285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Guide to COVID-19: a global pandemic caused by the novel coronavirus SARS-CoV-2. AU - Atzrodt,Cassandra L, AU - Maknojia,Insha, AU - McCarthy,Robert D P, AU - Oldfield,Tiara M, AU - Po,Jonathan, AU - Ta,Kenny T L, AU - Stepp,Hannah E, AU - Clements,Thomas P, Y1 - 2020/06/16/ PY - 2020/5/12/received PY - 2020/4/6/revised PY - 2020/5/19/accepted PY - 2020/5/24/pubmed PY - 2020/12/29/medline PY - 2020/5/24/entrez KW - ACE2 KW - COVID-19 KW - CRISPR KW - MERS KW - MERS-CoV KW - SARS KW - SARS-CoV KW - SARS-CoV-2 KW - coronavirus KW - vaccine SP - 3633 EP - 3650 JF - The FEBS journal JO - FEBS J VL - 287 IS - 17 N2 - The emergence of the SARS-CoV-2 strain of the human coronavirus has thrown the world into the midst of a new pandemic. In the human body, the virus causes COVID-19, a disease characterized by shortness of breath, fever, and pneumonia, which can be fatal in vulnerable individuals. SARS-CoV-2 has characteristics of past human coronaviruses, with close genomic similarities to SARS-CoV, the virus that causes the disease SARS. Like these related coronaviruses, SARS-CoV-2 is transmitted through the inhalation of droplets and interaction with contaminated surfaces. Across the world, laboratories are developing candidate vaccines for the virus - with vaccine trials underway in the United States and the United Kingdom - and considering various drugs for possible treatments and prophylaxis. Here, we provide an overview of SARS-CoV-2 by analyzing its virology, epidemiology, and modes of transmission while examining the current progress of testing procedures and possible treatments through drugs and vaccines. SN - 1742-4658 UR - https://www.unboundmedicine.com/medline/citation/32446285/A_Guide_to_COVID_19:_a_global_pandemic_caused_by_the_novel_coronavirus_SARS_CoV_2_ DB - PRIME DP - Unbound Medicine ER -