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Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment.
Cancer Radiother. 2020 Jul; 24(4):332-334.CR

Abstract

Monte Carlo simulations of γ/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient "acid-spike" response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy.

Authors+Show Affiliations

Département de médecine nucléaire et de radiobiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12(e) Avenue Nord, Sherbrooke, Québec, J1H 5N4, Canada. Electronic address: jean-paul.jay-gerin@USherbrooke.ca.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32446537

Citation

Jay-Gerin, J-P. "Ultra-high Dose-rate (FLASH) Radiotherapy: Generation of Early, Transient, Strongly Acidic Spikes in the Irradiated Tumor Environment." Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique, vol. 24, no. 4, 2020, pp. 332-334.
Jay-Gerin JP. Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment. Cancer Radiother. 2020;24(4):332-334.
Jay-Gerin, J. P. (2020). Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment. Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique, 24(4), 332-334. https://doi.org/10.1016/j.canrad.2019.11.004
Jay-Gerin JP. Ultra-high Dose-rate (FLASH) Radiotherapy: Generation of Early, Transient, Strongly Acidic Spikes in the Irradiated Tumor Environment. Cancer Radiother. 2020;24(4):332-334. PubMed PMID: 32446537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultra-high dose-rate (FLASH) radiotherapy: Generation of early, transient, strongly acidic spikes in the irradiated tumor environment. A1 - Jay-Gerin,J-P, Y1 - 2020/05/20/ PY - 2019/10/23/received PY - 2019/11/05/revised PY - 2019/11/13/accepted PY - 2020/5/25/pubmed PY - 2020/6/26/medline PY - 2020/5/25/entrez KW - Acid spike KW - Chemical yield KW - Eau liquide KW - FLASH radiotherapy KW - Hydronium ion (H(3)O(+)) KW - Liquid water KW - Monte Carlo track chemistry simulation KW - Pic d’acidité KW - Radiolyse KW - Radiolysis KW - Radiothérapie « FLASH » KW - Rendement en ions hydronium (H(3)O(+)) KW - Simulation Monte Carlo de la chimie des trajectoires KW - pH SP - 332 EP - 334 JF - Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique JO - Cancer Radiother VL - 24 IS - 4 N2 - Monte Carlo simulations of γ/fast electron-radiolysis of water show that the in situ formation of H3O+ temporarily renders each "native" isolated spur/track region very acidic. For pulsed (FLASH) irradiation with high dose rate, this early time, transient "acid-spike" response is shown to extend evenly across the entire irradiated volume. Since pH controls many cellular processes, this study highlights the need to consider these spikes of acidity in understanding the fundamental mechanisms underlying FLASH radiotherapy. SN - 1769-6658 UR - https://www.unboundmedicine.com/medline/citation/32446537/Ultra-high_dose-rate_(FLASH)_radiotherapy:_Generation_of_early,_transient,_strongly_acidic_spikes_in_the_irradiated_tumor_environment L2 - https://linkinghub.elsevier.com/retrieve/pii/S1278-3218(20)30060-3 DB - PRIME DP - Unbound Medicine ER -