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The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system.
Cytokine Growth Factor Rev. 2020 06; 53:25-32.CG

Abstract

In 2019-2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. Available evidence indicate that the so called "cytokine storm" an uncontrolled over-production of soluble markers of inflammation which, in turn, sustain an aberrant systemic inflammatory response, is a major responsible for the occurrence of ARDS. Chemokines are low molecular weight proteins with powerful chemoattractant activity which play a role in the immune cell recruitment during inflammation. This review will be aimed at providing an overview of the current knowledge on the involvement of the chemokine/chemokine-receptor system in the cytokine storm related to SARS-CoV-2 infection. Basic and clinical evidences obtained from previous SARS and MERS epidemics and available data from COVID-19 will be taken into account.

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Authors+Show Affiliations

Coperchini F
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, 27100 Pavia, PV, Italy.
Chiovato L
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, 27100 Pavia, PV, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, PV, Italy.
Croce L
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, 27100 Pavia, PV, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, PV, Italy.
Magri F
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, 27100 Pavia, PV, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, PV, Italy.
Rotondi M
Istituti Clinici Scientifici Maugeri IRCCS, Unit of Internal Medicine and Endocrinology, Laboratory for Endocrine Disruptors, 27100 Pavia, PV, Italy; Department of Internal Medicine and Therapeutics, University of Pavia, 27100 Pavia, PV, Italy. Electronic address: mario.rotondi@icsmaugeri.it.

MeSH

BetacoronavirusCOVID-19ChemokinesCoronavirus InfectionsCytokine Release SyndromeHumansPandemicsPneumonia, ViralReceptors, ChemokineSARS-CoV-2Severe Acute Respiratory Syndrome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32446778

Citation

Coperchini, Francesca, et al. "The Cytokine Storm in COVID-19: an Overview of the Involvement of the Chemokine/chemokine-receptor System." Cytokine & Growth Factor Reviews, vol. 53, 2020, pp. 25-32.
Coperchini F, Chiovato L, Croce L, et al. The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system. Cytokine Growth Factor Rev. 2020;53:25-32.
Coperchini, F., Chiovato, L., Croce, L., Magri, F., & Rotondi, M. (2020). The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system. Cytokine & Growth Factor Reviews, 53, 25-32. https://doi.org/10.1016/j.cytogfr.2020.05.003
Coperchini F, et al. The Cytokine Storm in COVID-19: an Overview of the Involvement of the Chemokine/chemokine-receptor System. Cytokine Growth Factor Rev. 2020;53:25-32. PubMed PMID: 32446778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system. AU - Coperchini,Francesca, AU - Chiovato,Luca, AU - Croce,Laura, AU - Magri,Flavia, AU - Rotondi,Mario, Y1 - 2020/05/11/ PY - 2020/05/06/received PY - 2020/05/07/accepted PY - 2020/5/25/pubmed PY - 2020/7/1/medline PY - 2020/5/25/entrez KW - COVID-19 KW - CXCL10 KW - CXCL8 KW - Chemokines KW - Coronavirus KW - Cytokine storm SP - 25 EP - 32 JF - Cytokine & growth factor reviews JO - Cytokine Growth Factor Rev VL - 53 N2 - In 2019-2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. Available evidence indicate that the so called "cytokine storm" an uncontrolled over-production of soluble markers of inflammation which, in turn, sustain an aberrant systemic inflammatory response, is a major responsible for the occurrence of ARDS. Chemokines are low molecular weight proteins with powerful chemoattractant activity which play a role in the immune cell recruitment during inflammation. This review will be aimed at providing an overview of the current knowledge on the involvement of the chemokine/chemokine-receptor system in the cytokine storm related to SARS-CoV-2 infection. Basic and clinical evidences obtained from previous SARS and MERS epidemics and available data from COVID-19 will be taken into account. SN - 1879-0305 UR - https://www.unboundmedicine.com/medline/citation/32446778/The_cytokine_storm_in_COVID_19:_An_overview_of_the_involvement_of_the_chemokine/chemokine_receptor_system_ DB - PRIME DP - Unbound Medicine ER -