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SARS-CoV-2 Infection Leads to Neurological Dysfunction.
J Neuroimmune Pharmacol. 2020 06; 15(2):167-173.JN

Abstract

A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demonstrate headache, nausea and vomiting, up to 40% present also experience dizziness, confusion, cerebrovascular disease, muscle pain, ataxia and seizures. Loss of taste and smell, defects in visual acuity and pain occur in parallel. Such central nervous system (CNS) signs and symptoms linked to laboratory-confirmed SARS-CoV-2 infection is often life threatening. Health care providers currently evaluating patients with neurologic symptoms need consider COVID-19 in any differential diagnosis. These considerations will facilitate prompt testing, isolation and prevention of viral transmission speeding best clinical outcomes. Graphical Abstract.

Authors+Show Affiliations

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Interventional Regeneration Medicine and Imaging Laboratory, Department of Radiology, Stanford University, Palo Alto, CA, 94304, USA.Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. hegendel@unmc.edu.Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA. sid.byrareddy@unmc.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

32447746

Citation

Acharya, Arpan, et al. "SARS-CoV-2 Infection Leads to Neurological Dysfunction." Journal of Neuroimmune Pharmacology : the Official Journal of the Society On NeuroImmune Pharmacology, vol. 15, no. 2, 2020, pp. 167-173.
Acharya A, Kevadiya BD, Gendelman HE, et al. SARS-CoV-2 Infection Leads to Neurological Dysfunction. J Neuroimmune Pharmacol. 2020;15(2):167-173.
Acharya, A., Kevadiya, B. D., Gendelman, H. E., & Byrareddy, S. N. (2020). SARS-CoV-2 Infection Leads to Neurological Dysfunction. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On NeuroImmune Pharmacology, 15(2), 167-173. https://doi.org/10.1007/s11481-020-09924-9
Acharya A, et al. SARS-CoV-2 Infection Leads to Neurological Dysfunction. J Neuroimmune Pharmacol. 2020;15(2):167-173. PubMed PMID: 32447746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 Infection Leads to Neurological Dysfunction. AU - Acharya,Arpan, AU - Kevadiya,Bhavesh D, AU - Gendelman,Howard E, AU - Byrareddy,Siddappa N, Y1 - 2020/05/23/ PY - 2020/04/28/received PY - 2020/05/06/accepted PY - 2020/5/25/pubmed PY - 2020/6/12/medline PY - 2020/5/25/entrez KW - Animal models KW - CNS KW - COVID-19 KW - Guillain-Barré syndrome KW - Neurologic manifestations KW - SARS-CoV-2 KW - Therapeutics SP - 167 EP - 173 JF - Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology JO - J Neuroimmune Pharmacol VL - 15 IS - 2 N2 - A number of neurological disease complications have been seen following infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While most person with COVID-19 respiratory disease demonstrate headache, nausea and vomiting, up to 40% present also experience dizziness, confusion, cerebrovascular disease, muscle pain, ataxia and seizures. Loss of taste and smell, defects in visual acuity and pain occur in parallel. Such central nervous system (CNS) signs and symptoms linked to laboratory-confirmed SARS-CoV-2 infection is often life threatening. Health care providers currently evaluating patients with neurologic symptoms need consider COVID-19 in any differential diagnosis. These considerations will facilitate prompt testing, isolation and prevention of viral transmission speeding best clinical outcomes. Graphical Abstract. SN - 1557-1904 UR - https://www.unboundmedicine.com/medline/citation/32447746/SARS_CoV_2_Infection_Leads_to_Neurological_Dysfunction_ L2 - https://doi.org/10.1007/s11481-020-09924-9 DB - PRIME DP - Unbound Medicine ER -