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Relationship between the Diabetic Polyneuropathy Index and the Neurological Findings of Diabetic Polyneuropathy.
Intern Med. 2020 Aug 15; 59(16):1957-1962.IM

Abstract

Objective To achieve an accurate quantification in diabetic polyneuropathy (DPN), we developed a new electrophysiological index that we called the DPN index. The relationship between the DPN index and the neurological findings in diabetic patients was assessed. Methods The DPN index was calculated by the mean value of percentages of four parameters (tibial compound muscle action potential amplitude / F wave minimum latency, sural sensory nerve action potential amplitude / sensory nerve conduction velocity) against the mean normal values. Twenty healthy subjects were recruited as a control group. Patients A total of 348 diabetic patients who were hospitalized in our hospital during the period from December 2016 to August 2019 were retrospectively studied. The correlations between the DPN index and five neurological findings (subjective sensory symptoms, diminished or absent Achilles tendon reflex, impaired tactile and vibration sense, low coefficient of variation of R-R interval) were evaluated. Results The DPN index in healthy subjects was 129.3±32.7%. The DPN index in diabetic patients with one or more neurological findings was significantly lower than that in diabetic patients without any neurological findings (p<0.01: 89.3±27.8% vs. 118.4±21.2%). For each of the five neurological findings, the DPN index in the group with an abnormality was significantly lower than that in the group without any abnormality (each p<0.01). Spearman's correlation coefficients indicated that a greater number of neurological findings resulted in a lower DPN index (r=-0.711, p<0.01). Conclusion Our study suggested that the DPN index is useful for evaluating the severity of DPN.

Authors+Show Affiliations

Department of Neurology, Kawasaki Medical School, Japan.Department of Neurology, Kawasaki Medical School General Medical Center, Japan.Department of Neurology, Okayama Kyokuto Hospital, Japan.Department of Neurology, Kawasaki Medical School, Japan.Central Laboratory, Kawasaki Medical School, Japan.Central Laboratory, Kawasaki Medical School, Japan.Department of Neurology, Kawasaki Medical School, Japan.Department of Neurology, Kawasaki Medical School, Japan.Department of Neurology, Kawasaki Medical School, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32448837

Citation

Hemmi, Shoji, et al. "Relationship Between the Diabetic Polyneuropathy Index and the Neurological Findings of Diabetic Polyneuropathy." Internal Medicine (Tokyo, Japan), vol. 59, no. 16, 2020, pp. 1957-1962.
Hemmi S, Kurokawa K, Nagai T, et al. Relationship between the Diabetic Polyneuropathy Index and the Neurological Findings of Diabetic Polyneuropathy. Intern Med. 2020;59(16):1957-1962.
Hemmi, S., Kurokawa, K., Nagai, T., Yokoi, K., Okamoto, T., Asano, A., Murakami, T., Mihara, M., & Sunada, Y. (2020). Relationship between the Diabetic Polyneuropathy Index and the Neurological Findings of Diabetic Polyneuropathy. Internal Medicine (Tokyo, Japan), 59(16), 1957-1962. https://doi.org/10.2169/internalmedicine.4499-20
Hemmi S, et al. Relationship Between the Diabetic Polyneuropathy Index and the Neurological Findings of Diabetic Polyneuropathy. Intern Med. 2020 Aug 15;59(16):1957-1962. PubMed PMID: 32448837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between the Diabetic Polyneuropathy Index and the Neurological Findings of Diabetic Polyneuropathy. AU - Hemmi,Shoji, AU - Kurokawa,Katsumi, AU - Nagai,Taiji, AU - Yokoi,Keiichi, AU - Okamoto,Toshio, AU - Asano,Akio, AU - Murakami,Tatsufumi, AU - Mihara,Masahito, AU - Sunada,Yoshihide, Y1 - 2020/05/23/ PY - 2020/5/26/pubmed PY - 2020/5/26/medline PY - 2020/5/26/entrez KW - F wave minimum latency KW - compound muscle action potential KW - diabetes KW - diabetic polyneuropathy index KW - sensory nerve action potential KW - sensory nerve conduction velocity SP - 1957 EP - 1962 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 59 IS - 16 N2 - Objective To achieve an accurate quantification in diabetic polyneuropathy (DPN), we developed a new electrophysiological index that we called the DPN index. The relationship between the DPN index and the neurological findings in diabetic patients was assessed. Methods The DPN index was calculated by the mean value of percentages of four parameters (tibial compound muscle action potential amplitude / F wave minimum latency, sural sensory nerve action potential amplitude / sensory nerve conduction velocity) against the mean normal values. Twenty healthy subjects were recruited as a control group. Patients A total of 348 diabetic patients who were hospitalized in our hospital during the period from December 2016 to August 2019 were retrospectively studied. The correlations between the DPN index and five neurological findings (subjective sensory symptoms, diminished or absent Achilles tendon reflex, impaired tactile and vibration sense, low coefficient of variation of R-R interval) were evaluated. Results The DPN index in healthy subjects was 129.3±32.7%. The DPN index in diabetic patients with one or more neurological findings was significantly lower than that in diabetic patients without any neurological findings (p<0.01: 89.3±27.8% vs. 118.4±21.2%). For each of the five neurological findings, the DPN index in the group with an abnormality was significantly lower than that in the group without any abnormality (each p<0.01). Spearman's correlation coefficients indicated that a greater number of neurological findings resulted in a lower DPN index (r=-0.711, p<0.01). Conclusion Our study suggested that the DPN index is useful for evaluating the severity of DPN. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/32448837/Relationship_between_the_Diabetic_Polyneuropathy_Index_and_the_Neurological_Findings_of_Diabetic_Polyneuropathy_ L2 - https://dx.doi.org/10.2169/internalmedicine.4499-20 DB - PRIME DP - Unbound Medicine ER -