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One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test.
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Oct 05; 239:118474.SA

Abstract

Asenapine maleate was approved by the FDA for the treatment of schizophrenia and mania or mixed episodes with bipolar I disorder. In the present article, two spectroscopic methods were developed and validated for the determination of asenapine. Both methods depend on association complex formation between xanthine based dye (eosin Y) and the cited drug in acetate buffer pH = 3.8. In the spectrophotometric method (method I), the absorbance of the formed complex was estimated at maximum wavelength of 545 nm and Beer's law was obeyed in the range of 1-12 μg mL-1. The spectrofluorimetric method (method II) depends on measuring the quenching effect of the drug on the native fluorescence of eosin Y at 545 nm after excitation at 303 nm. The linearity range of method II was 0.4-3.2 μg mL-1. The limits of detection were 0.24 and 0.08 μg mL-1 for method I and II, respectively. The instructions of ICH were followed to fully validate the developed analytical procedures. The formation constant of the reaction was 3.93 × 104 while its Gibb's free energy was -2.6 × 104 J mol-1. Finally, the methods were applied for the analysis of pharmaceutical tablets and for evaluation of their content uniformity.

Authors+Show Affiliations

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt. Electronic address: ahmedabuhassan@azhar.edu.eg.Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32450539

Citation

Abu-Hassan, Ahmed A., et al. "One-pot Reaction for Determination of Asenapine Maleate Through Facile Complex Formation With Xanthine Based Dye: Application to Content Uniformity Test." Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, vol. 239, 2020, p. 118474.
Abu-Hassan AA, Ali R, Derayea SM. One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test. Spectrochim Acta A Mol Biomol Spectrosc. 2020;239:118474.
Abu-Hassan, A. A., Ali, R., & Derayea, S. M. (2020). One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 239, 118474. https://doi.org/10.1016/j.saa.2020.118474
Abu-Hassan AA, Ali R, Derayea SM. One-pot Reaction for Determination of Asenapine Maleate Through Facile Complex Formation With Xanthine Based Dye: Application to Content Uniformity Test. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Oct 5;239:118474. PubMed PMID: 32450539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-pot reaction for determination of Asenapine maleate through facile complex formation with xanthine based dye: Application to content uniformity test. AU - Abu-Hassan,Ahmed A, AU - Ali,Ramadan, AU - Derayea,Sayed M, Y1 - 2020/05/14/ PY - 2020/04/01/received PY - 2020/04/21/revised PY - 2020/05/10/accepted PY - 2020/5/26/pubmed PY - 2020/5/26/medline PY - 2020/5/26/entrez KW - Asenapine maleate KW - Colorimetry KW - Content uniformity test KW - Eosin Y KW - Spectrofluorimetry SP - 118474 EP - 118474 JF - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy JO - Spectrochim Acta A Mol Biomol Spectrosc VL - 239 N2 - Asenapine maleate was approved by the FDA for the treatment of schizophrenia and mania or mixed episodes with bipolar I disorder. In the present article, two spectroscopic methods were developed and validated for the determination of asenapine. Both methods depend on association complex formation between xanthine based dye (eosin Y) and the cited drug in acetate buffer pH = 3.8. In the spectrophotometric method (method I), the absorbance of the formed complex was estimated at maximum wavelength of 545 nm and Beer's law was obeyed in the range of 1-12 μg mL-1. The spectrofluorimetric method (method II) depends on measuring the quenching effect of the drug on the native fluorescence of eosin Y at 545 nm after excitation at 303 nm. The linearity range of method II was 0.4-3.2 μg mL-1. The limits of detection were 0.24 and 0.08 μg mL-1 for method I and II, respectively. The instructions of ICH were followed to fully validate the developed analytical procedures. The formation constant of the reaction was 3.93 × 104 while its Gibb's free energy was -2.6 × 104 J mol-1. Finally, the methods were applied for the analysis of pharmaceutical tablets and for evaluation of their content uniformity. SN - 1873-3557 UR - https://www.unboundmedicine.com/medline/citation/32450539/One-pot_reaction_for_determination_of_Asenapine_maleate_through_facile_complex_formation_with_xanthine_based_dye:_Application_to_content_uniformity_test L2 - https://linkinghub.elsevier.com/retrieve/pii/S1386-1425(20)30452-2 DB - PRIME DP - Unbound Medicine ER -
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