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Chest CT-based differential diagnosis of 28 patients with suspected corona virus disease 2019 (COVID-19).
Br J Radiol. 2020 Aug; 93(1112):20200243.BJ

Abstract

OBJECTIVES

The chest CT findings that can distinguish patients with corona virus disease 2019 (COVID-19) from those with clinically suspected COVID-19 but subsequently found to be COVID-19 negative have not previously been described in detail. The purpose of this study was to determine the distinctions among patients with COVID-19 by comparing the imaging findings of patients with suspected confirmed COVID-19 and those of patients initially suspected to have COVID-19 who were ultimately negative for the disease.

METHODS

28 isolated suspected in-patients with COVID-19 were enrolled in this retrospective study from January 22, 2020 to February 6, 2020. 12 patients were confirmed to have positive severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) RNA results, and 16 patients had negative results. The thin-section CT imaging findings and clinical and laboratory data of all the patients were evaluated.

RESULTS

There were no significant differences between the 12 confirmed COVID-19 (SARS-Cov-2-positive) patients and 16 SARS-CoV-2-negative patients in epidemiology and most of the clinical features or laboratory data. The CT images showed that the incidence of pure/mixed ground-glass opacities (GGOs) was not different between COVID-19 and SARS-CoV-2-negative patients [9/12 (75.0%) vs 10/16 (62.5%), p = 0.687], but pure/mixed GGOs in the peripheral were more common in patients with COVID-19 [11/12 (91.7%) vs 6/16 (37.5%), p = 0.006]. There were no significant differences in the number of lesions, bilateral lung involvement, large irregular/patchy opacities, rounded opacities, linear opacities, crazy-paving patterns, halo signs, interlobular septal thickening or air bronchograms.

CONCLUSIONS

Although peripheral pure/mixed GGOs on CT may help distinguish patients with COVID-19 from clinically suspected but negative patients, CT cannot replace RT-PCR testing.

ADVANCES IN KNOWLEDGE

Peripheral pure/mixed GGOs on-chest CT findings can be helpful in distinguishing patients with COVID-19 from those with clinically suspected COVID-19 but subsequently found to be COVID-19 negative.

Authors+Show Affiliations

Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Infectious Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Infectious Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.Department of Infectious Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32450727

Citation

Xie, Sidong, et al. "Chest CT-based Differential Diagnosis of 28 Patients With Suspected Corona Virus Disease 2019 (COVID-19)." The British Journal of Radiology, vol. 93, no. 1112, 2020, p. 20200243.
Xie S, Lei Z, Chen X, et al. Chest CT-based differential diagnosis of 28 patients with suspected corona virus disease 2019 (COVID-19). Br J Radiol. 2020;93(1112):20200243.
Xie, S., Lei, Z., Chen, X., Liu, W., Wang, X., Dong, Y., Guo, Y., Duan, Y., Cao, H., Qin, J., & Lin, B. (2020). Chest CT-based differential diagnosis of 28 patients with suspected corona virus disease 2019 (COVID-19). The British Journal of Radiology, 93(1112), 20200243. https://doi.org/10.1259/bjr.20200243
Xie S, et al. Chest CT-based Differential Diagnosis of 28 Patients With Suspected Corona Virus Disease 2019 (COVID-19). Br J Radiol. 2020;93(1112):20200243. PubMed PMID: 32450727.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chest CT-based differential diagnosis of 28 patients with suspected corona virus disease 2019 (COVID-19). AU - Xie,Sidong, AU - Lei,Ziying, AU - Chen,Xiuzhen, AU - Liu,Weimin, AU - Wang,Xiaohong, AU - Dong,Yunxu, AU - Guo,Yuefei, AU - Duan,Yani, AU - Cao,Huijuan, AU - Qin,Jie, AU - Lin,Bingliang, Y1 - 2020/06/02/ PY - 2021/08/01/pmc-release PY - 2020/5/27/pubmed PY - 2020/7/28/medline PY - 2020/5/27/entrez SP - 20200243 EP - 20200243 JF - The British journal of radiology JO - Br J Radiol VL - 93 IS - 1112 N2 - OBJECTIVES: The chest CT findings that can distinguish patients with corona virus disease 2019 (COVID-19) from those with clinically suspected COVID-19 but subsequently found to be COVID-19 negative have not previously been described in detail. The purpose of this study was to determine the distinctions among patients with COVID-19 by comparing the imaging findings of patients with suspected confirmed COVID-19 and those of patients initially suspected to have COVID-19 who were ultimately negative for the disease. METHODS: 28 isolated suspected in-patients with COVID-19 were enrolled in this retrospective study from January 22, 2020 to February 6, 2020. 12 patients were confirmed to have positive severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) RNA results, and 16 patients had negative results. The thin-section CT imaging findings and clinical and laboratory data of all the patients were evaluated. RESULTS: There were no significant differences between the 12 confirmed COVID-19 (SARS-Cov-2-positive) patients and 16 SARS-CoV-2-negative patients in epidemiology and most of the clinical features or laboratory data. The CT images showed that the incidence of pure/mixed ground-glass opacities (GGOs) was not different between COVID-19 and SARS-CoV-2-negative patients [9/12 (75.0%) vs 10/16 (62.5%), p = 0.687], but pure/mixed GGOs in the peripheral were more common in patients with COVID-19 [11/12 (91.7%) vs 6/16 (37.5%), p = 0.006]. There were no significant differences in the number of lesions, bilateral lung involvement, large irregular/patchy opacities, rounded opacities, linear opacities, crazy-paving patterns, halo signs, interlobular septal thickening or air bronchograms. CONCLUSIONS: Although peripheral pure/mixed GGOs on CT may help distinguish patients with COVID-19 from clinically suspected but negative patients, CT cannot replace RT-PCR testing. ADVANCES IN KNOWLEDGE: Peripheral pure/mixed GGOs on-chest CT findings can be helpful in distinguishing patients with COVID-19 from those with clinically suspected COVID-19 but subsequently found to be COVID-19 negative. SN - 1748-880X UR - https://www.unboundmedicine.com/medline/citation/32450727/Chest_CT_based_differential_diagnosis_of_28_patients_with_suspected_corona_virus_disease_2019__COVID_19__ L2 - https://www.birpublications.org/doi/10.1259/bjr.20200243?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -