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A Comparison of Clinical and Chest CT Findings in Patients With Influenza A (H1N1) Virus Infection and Coronavirus Disease (COVID-19).
AJR Am J Roentgenol. 2020 11; 215(5):1065-1071.AA

Abstract

OBJECTIVE.

The purpose of this study was to compare clinical and chest CT findings in patients with influenza A (H1N1) pneumonia and coronavirus disease (COVID-19) pneumonia. MATERIALS AND

METHODS.

Thirty patients with diagnosed influenza A (H1N1) virus infection (group A) and 30 patients with diagnosed COVID-19 (group B) were retrospectively enrolled in the present study. The clinical characteristics and chest CT findings of the two groups were compared.

RESULTS.

Fever, cough, expectoration, and dyspnea were the main symptoms in both groups with viral pneumonia, with cough and expectoration more frequently found in group A. Lymphopenia, an elevated C-reactive protein level, and an increased erythrocyte sedimentation rate were common laboratory test findings in the two groups. The median time from symptom onset to CT in group A and group B was 6 and 15 days, respectively, and the median total CT score of the pulmonary lobes involved was 6 and 13, respectively. Linear opacification, crazy-paving sign, vascular enlargement, were more common in group B. In contrast, bronchiectasis and pleural effusion were more common in group A. Other common CT features, including peripheral or peribronchovascular distribution, ground-glass opacities (GGOs), consolidation, subpleural line, air bronchogram, and bronchial distortion, did not show statistical significance.

CONCLUSION.

On CT, the significant differences between influenza A (H1N1) pneumonia and COVID-19 pneumonia were findings of linear opacification, crazy-paving sign, vascular enlargement, pleural thickening, and pleural effusion, which were more common in patients with COVID-19 pneumonia, and bronchiectasis and pleural effusion, which were more common in patients with influenza A (H1N1) pneumonia. Other imaging findings, including peripheral or peribronchovascular distribution, ground-glass opacities (GGO), consolidation, subpleural line, air bronchogram, and bronchial distortion, were not significantly different between the two patient groups.

Authors+Show Affiliations

Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China. Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, #139, Renmin Middle Rd, Changsha 410011, China.Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, #139, Renmin Middle Rd, Changsha 410011, China.Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, #139, Renmin Middle Rd, Changsha 410011, China.Department of Pulmonary and Critical Care Medicine, Second Xiangya Hospital, Central South University, #139, Renmin Middle Rd, Changsha 410011, China.Department of Radiology, Second Xiangya Hospital, Central South University, Changsha, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32452731

Citation

Yin, Zhilan, et al. "A Comparison of Clinical and Chest CT Findings in Patients With Influenza a (H1N1) Virus Infection and Coronavirus Disease (COVID-19)." AJR. American Journal of Roentgenology, vol. 215, no. 5, 2020, pp. 1065-1071.
Yin Z, Kang Z, Yang D, et al. A Comparison of Clinical and Chest CT Findings in Patients With Influenza A (H1N1) Virus Infection and Coronavirus Disease (COVID-19). AJR Am J Roentgenol. 2020;215(5):1065-1071.
Yin, Z., Kang, Z., Yang, D., Ding, S., Luo, H., & Xiao, E. (2020). A Comparison of Clinical and Chest CT Findings in Patients With Influenza A (H1N1) Virus Infection and Coronavirus Disease (COVID-19). AJR. American Journal of Roentgenology, 215(5), 1065-1071. https://doi.org/10.2214/AJR.20.23214
Yin Z, et al. A Comparison of Clinical and Chest CT Findings in Patients With Influenza a (H1N1) Virus Infection and Coronavirus Disease (COVID-19). AJR Am J Roentgenol. 2020;215(5):1065-1071. PubMed PMID: 32452731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Comparison of Clinical and Chest CT Findings in Patients With Influenza A (H1N1) Virus Infection and Coronavirus Disease (COVID-19). AU - Yin,Zhilan, AU - Kang,Zhen, AU - Yang,Danhui, AU - Ding,Shuizi, AU - Luo,Hong, AU - Xiao,Enhua, Y1 - 2020/05/26/ PY - 2020/5/27/pubmed PY - 2020/10/30/medline PY - 2020/5/27/entrez KW - COVID-19 KW - CT KW - coronavirus disease KW - influenza A (H1N1) virus KW - pneumonia KW - viral pneumonia SP - 1065 EP - 1071 JF - AJR. American journal of roentgenology JO - AJR Am J Roentgenol VL - 215 IS - 5 N2 - OBJECTIVE. The purpose of this study was to compare clinical and chest CT findings in patients with influenza A (H1N1) pneumonia and coronavirus disease (COVID-19) pneumonia. MATERIALS AND METHODS. Thirty patients with diagnosed influenza A (H1N1) virus infection (group A) and 30 patients with diagnosed COVID-19 (group B) were retrospectively enrolled in the present study. The clinical characteristics and chest CT findings of the two groups were compared. RESULTS. Fever, cough, expectoration, and dyspnea were the main symptoms in both groups with viral pneumonia, with cough and expectoration more frequently found in group A. Lymphopenia, an elevated C-reactive protein level, and an increased erythrocyte sedimentation rate were common laboratory test findings in the two groups. The median time from symptom onset to CT in group A and group B was 6 and 15 days, respectively, and the median total CT score of the pulmonary lobes involved was 6 and 13, respectively. Linear opacification, crazy-paving sign, vascular enlargement, were more common in group B. In contrast, bronchiectasis and pleural effusion were more common in group A. Other common CT features, including peripheral or peribronchovascular distribution, ground-glass opacities (GGOs), consolidation, subpleural line, air bronchogram, and bronchial distortion, did not show statistical significance. CONCLUSION. On CT, the significant differences between influenza A (H1N1) pneumonia and COVID-19 pneumonia were findings of linear opacification, crazy-paving sign, vascular enlargement, pleural thickening, and pleural effusion, which were more common in patients with COVID-19 pneumonia, and bronchiectasis and pleural effusion, which were more common in patients with influenza A (H1N1) pneumonia. Other imaging findings, including peripheral or peribronchovascular distribution, ground-glass opacities (GGO), consolidation, subpleural line, air bronchogram, and bronchial distortion, were not significantly different between the two patient groups. SN - 1546-3141 UR - https://www.unboundmedicine.com/medline/citation/32452731/A_Comparison_of_Clinical_and_Chest_CT_Findings_in_Patients_With_Influenza_A__H1N1__Virus_Infection_and_Coronavirus_Disease__COVID_19__ L2 - https://www.ajronline.org/doi/10.2214/AJR.20.23214 DB - PRIME DP - Unbound Medicine ER -