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Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent.
Nutrients. 2020 May 21; 12(5)N

Abstract

Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a 'second face'-as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties.

Authors+Show Affiliations

DNA Damage Laboratory of Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.DNA Damage Laboratory of Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.DNA Damage Laboratory of Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.DNA Damage Laboratory of Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32455696

Citation

Kaźmierczak-Barańska, Julia, et al. "Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent." Nutrients, vol. 12, no. 5, 2020.
Kaźmierczak-Barańska J, Boguszewska K, Adamus-Grabicka A, et al. Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. Nutrients. 2020;12(5).
Kaźmierczak-Barańska, J., Boguszewska, K., Adamus-Grabicka, A., & Karwowski, B. T. (2020). Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. Nutrients, 12(5). https://doi.org/10.3390/nu12051501
Kaźmierczak-Barańska J, et al. Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. Nutrients. 2020 May 21;12(5) PubMed PMID: 32455696.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two Faces of Vitamin C-Antioxidative and Pro-Oxidative Agent. AU - Kaźmierczak-Barańska,Julia, AU - Boguszewska,Karolina, AU - Adamus-Grabicka,Angelika, AU - Karwowski,Bolesław T, Y1 - 2020/05/21/ PY - 2020/04/23/received PY - 2020/05/17/revised PY - 2020/05/19/accepted PY - 2020/5/28/entrez PY - 2020/5/28/pubmed PY - 2020/5/28/medline KW - DNA lesions KW - anticancer activity KW - antioxidants KW - pro-oxidative factor KW - radioprotective properties KW - vitamin C JF - Nutrients JO - Nutrients VL - 12 IS - 5 N2 - Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a 'second face'-as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/32455696/Two_Faces_of_Vitamin_C-Antioxidative_and_Pro-Oxidative_Agent L2 - https://www.mdpi.com/resolver?pii=nu12051501 DB - PRIME DP - Unbound Medicine ER -
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