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Impact of Symbiosis Between Trichomonas vaginalis and Mycoplasma hominis on Vaginal Dysbiosis: A Mini Review.

Abstract

The protozoon Trichomonas vaginalis is responsible for trichomoniasis, a common sexually transmitted infection associated with an increased risk of HIV infection and adverse pregnancy outcomes. The protozoon has the surprising ability to establish a symbiotic relationship with other microorganisms. In fact, most T.vaginalis isolates intracellularly host the vaginal bacterium Mycoplasma hominis and can harbor up to four dsRNA viruses. Moreover, a novel Mycoplasma species named Ca. Mycoplasma girerdii has been recently described as associated with trichomonad cells. Trichomonas vaginalis colonizes the human vagina and its presence causes profound alterations of the resident microbiota, leading to dysbiosis. In healthy women, vaginal microbiota is characterized by the presence of a complex population of aerobic and anaerobic microorganisms living in a physiologically dynamic system dominated by bacteria of the genera Lactobacillus. The most common microbial vaginal imbalance is bacterial vaginosis, a polymicrobial disease associated with several adverse reproductive outcomes and increased risk of HIV infection. Here, we review the current knowledge regarding the interactions between both T.vaginalis and M.hominis and the vaginal microbiota, and we discuss the possibility of a cooperation between T.vaginalis and its symbionts in the development of vaginal dysbiosis.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.Department of Biomedical Sciences, University of Sassari, Sassari, Italy. Mediterranean Center for Disease Control, Sassari, Italy.Department of Biomedical Sciences, University of Sassari, Sassari, Italy. Mediterranean Center for Disease Control, Sassari, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32457847

Citation

Margarita, Valentina, et al. "Impact of Symbiosis Between Trichomonas Vaginalis and Mycoplasma Hominis On Vaginal Dysbiosis: a Mini Review." Frontiers in Cellular and Infection Microbiology, vol. 10, 2020, p. 179.
Margarita V, Fiori PL, Rappelli P. Impact of Symbiosis Between Trichomonas vaginalis and Mycoplasma hominis on Vaginal Dysbiosis: A Mini Review. Front Cell Infect Microbiol. 2020;10:179.
Margarita, V., Fiori, P. L., & Rappelli, P. (2020). Impact of Symbiosis Between Trichomonas vaginalis and Mycoplasma hominis on Vaginal Dysbiosis: A Mini Review. Frontiers in Cellular and Infection Microbiology, 10, 179. https://doi.org/10.3389/fcimb.2020.00179
Margarita V, Fiori PL, Rappelli P. Impact of Symbiosis Between Trichomonas Vaginalis and Mycoplasma Hominis On Vaginal Dysbiosis: a Mini Review. Front Cell Infect Microbiol. 2020;10:179. PubMed PMID: 32457847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of Symbiosis Between Trichomonas vaginalis and Mycoplasma hominis on Vaginal Dysbiosis: A Mini Review. AU - Margarita,Valentina, AU - Fiori,Pier Luigi, AU - Rappelli,Paola, Y1 - 2020/05/08/ PY - 2020/02/13/received PY - 2020/04/03/accepted PY - 2020/5/28/entrez PY - 2020/5/28/pubmed PY - 2020/5/28/medline KW - Mycoplasma hominis KW - Trichomonas vaginalis KW - bacterial vaginosis KW - symbiosis KW - vaginal dysbiosis SP - 179 EP - 179 JF - Frontiers in cellular and infection microbiology JO - Front Cell Infect Microbiol VL - 10 N2 - The protozoon Trichomonas vaginalis is responsible for trichomoniasis, a common sexually transmitted infection associated with an increased risk of HIV infection and adverse pregnancy outcomes. The protozoon has the surprising ability to establish a symbiotic relationship with other microorganisms. In fact, most T.vaginalis isolates intracellularly host the vaginal bacterium Mycoplasma hominis and can harbor up to four dsRNA viruses. Moreover, a novel Mycoplasma species named Ca. Mycoplasma girerdii has been recently described as associated with trichomonad cells. Trichomonas vaginalis colonizes the human vagina and its presence causes profound alterations of the resident microbiota, leading to dysbiosis. In healthy women, vaginal microbiota is characterized by the presence of a complex population of aerobic and anaerobic microorganisms living in a physiologically dynamic system dominated by bacteria of the genera Lactobacillus. The most common microbial vaginal imbalance is bacterial vaginosis, a polymicrobial disease associated with several adverse reproductive outcomes and increased risk of HIV infection. Here, we review the current knowledge regarding the interactions between both T.vaginalis and M.hominis and the vaginal microbiota, and we discuss the possibility of a cooperation between T.vaginalis and its symbionts in the development of vaginal dysbiosis. SN - 2235-2988 UR - https://www.unboundmedicine.com/medline/citation/32457847/Impact_of_Symbiosis_Between_Trichomonas_vaginalis_and_Mycoplasma_hominis_on_Vaginal_Dysbiosis:_A_Mini_Review L2 - https://doi.org/10.3389/fcimb.2020.00179 DB - PRIME DP - Unbound Medicine ER -
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