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[Effect of schistosomiasis japonica on the development of gastric and colorectal cancer].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Apr 08; 32(2):148-153.ZX

Abstract

OBJECTIVE

To examine the effect of schistosomiasis on the development of gastric cancer and colorectal cancer.

METHODS

The clinical data of patients with gastric cancer and colorectal cancer with and without schistosomiasis japonica that were admitted to the Yijishan Hospital Affiliated to Wannan Medical College from January 2014 to December 2018 were collected. All cases were divided into schistosomal gastric cancer group and non - schistosomal gastric cancer group, schistosomal colorectal cancer group and non-schistosomal colorectal cancer group. The risk factors of gastric cancer and colorectal cancer were identified using univariate analysis and multivariate logistic regression analysis, and the effects of schistosomiasis on the development and progression of gastric cancer and colorectal cancer were evaluated. In addition, the survival of 32 patients with schistosomal colorectal cancer and 68 cases with non-schistosomal colorectal were estimated using telephone follow-up, and compared.

RESULTS

There were 113 patients with schistosomal gastric cancer and 3 741 cases with non-schistosomal gastric cancer enrolled in this study, and there were significant differences between them in terms of sex ratio, age and prevalence of Helico-bacter pylori infection (all P values < 0.05). Logistic regression analysis revealed that age, H. pylori infection, and schistosomiasis were independent risk factors for gastric cancer (all P values < 0.05). There were 184 patients with schistosomal colorectal cancer and 2 205 cases with non-schistosomal colorectal cancer recruited in this study, and there were significant differences between them in terms of age, sex ratio, rate of history of alcohol consumption and rate of positive fecal occult blood test (all P values < 0.05). The phenotypes of both schistosomal and non-schistosomal colorectal cancer were predominantly ulcerative; however, the proportion of patients with invasive and protruded colorectal cancer was significantly greater than that of patients with non-schistosomal colorectal cancer (P = 0.003). Logistic regression analysis revealed that age (P = 0.003), gender (P = 0.002), phenotype (P = 0.005) and schistosomiasis (P = 0.029) were independent risk factors for colorectal cancer. The 5-year survival rate was significantly higher in patients with schistosomal colorectal cancer (68.90%) than in those with non-schistosomal colorectal cancer (46.40%), and the dead patients with schistosomal colorectal cancer had a significantly greater mean age than those with non-schistosomal colorectal cancer [ (66.33 ± 3.08) years vs. (56.29 ± 1.94), P < 0.05].

CONCLUSIONS

Schistosomiasis may alter the pathogenesis of colorectal cancer, resulting in the differences in the epidemiology, clinical characteristics and 5-year survival rate between patients with schistosomal and non-schistosomal colorectal cancer. Periodical gastrointestinal endoscopy and other examinations are recommended to exclude the likelihood of gastrointestinal cancers in men with anemia of unknown causes and at ages of 60 years living in schistosomiasis-endemic areas.

Authors+Show Affiliations

Graduate School of Wannan Medical College, Wuhu 241001, China.Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu City, Anhui Province, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

32458603

Citation

Wang, Z J., and J H. Yang. "[Effect of Schistosomiasis Japonica On the Development of Gastric and Colorectal Cancer]." Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control, vol. 32, no. 2, 2020, pp. 148-153.
Wang ZJ, Yang JH. [Effect of schistosomiasis japonica on the development of gastric and colorectal cancer]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020;32(2):148-153.
Wang, Z. J., & Yang, J. H. (2020). [Effect of schistosomiasis japonica on the development of gastric and colorectal cancer]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi = Chinese Journal of Schistosomiasis Control, 32(2), 148-153. https://doi.org/10.16250/j.32.1374.2019240
Wang ZJ, Yang JH. [Effect of Schistosomiasis Japonica On the Development of Gastric and Colorectal Cancer]. Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2020 Apr 8;32(2):148-153. PubMed PMID: 32458603.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of schistosomiasis japonica on the development of gastric and colorectal cancer]. AU - Wang,Z J, AU - Yang,J H, PY - 2020/5/28/entrez PY - 2020/5/28/pubmed PY - 2020/6/5/medline KW - Clinical feature KW - Colorectal cancer KW - Gastric cancer KW - Risk factor KW - Schistosomiasis KW - Wuhu area SP - 148 EP - 153 JF - Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control JO - Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi VL - 32 IS - 2 N2 - OBJECTIVE: To examine the effect of schistosomiasis on the development of gastric cancer and colorectal cancer. METHODS: The clinical data of patients with gastric cancer and colorectal cancer with and without schistosomiasis japonica that were admitted to the Yijishan Hospital Affiliated to Wannan Medical College from January 2014 to December 2018 were collected. All cases were divided into schistosomal gastric cancer group and non - schistosomal gastric cancer group, schistosomal colorectal cancer group and non-schistosomal colorectal cancer group. The risk factors of gastric cancer and colorectal cancer were identified using univariate analysis and multivariate logistic regression analysis, and the effects of schistosomiasis on the development and progression of gastric cancer and colorectal cancer were evaluated. In addition, the survival of 32 patients with schistosomal colorectal cancer and 68 cases with non-schistosomal colorectal were estimated using telephone follow-up, and compared. RESULTS: There were 113 patients with schistosomal gastric cancer and 3 741 cases with non-schistosomal gastric cancer enrolled in this study, and there were significant differences between them in terms of sex ratio, age and prevalence of Helico-bacter pylori infection (all P values < 0.05). Logistic regression analysis revealed that age, H. pylori infection, and schistosomiasis were independent risk factors for gastric cancer (all P values < 0.05). There were 184 patients with schistosomal colorectal cancer and 2 205 cases with non-schistosomal colorectal cancer recruited in this study, and there were significant differences between them in terms of age, sex ratio, rate of history of alcohol consumption and rate of positive fecal occult blood test (all P values < 0.05). The phenotypes of both schistosomal and non-schistosomal colorectal cancer were predominantly ulcerative; however, the proportion of patients with invasive and protruded colorectal cancer was significantly greater than that of patients with non-schistosomal colorectal cancer (P = 0.003). Logistic regression analysis revealed that age (P = 0.003), gender (P = 0.002), phenotype (P = 0.005) and schistosomiasis (P = 0.029) were independent risk factors for colorectal cancer. The 5-year survival rate was significantly higher in patients with schistosomal colorectal cancer (68.90%) than in those with non-schistosomal colorectal cancer (46.40%), and the dead patients with schistosomal colorectal cancer had a significantly greater mean age than those with non-schistosomal colorectal cancer [ (66.33 ± 3.08) years vs. (56.29 ± 1.94), P < 0.05]. CONCLUSIONS: Schistosomiasis may alter the pathogenesis of colorectal cancer, resulting in the differences in the epidemiology, clinical characteristics and 5-year survival rate between patients with schistosomal and non-schistosomal colorectal cancer. Periodical gastrointestinal endoscopy and other examinations are recommended to exclude the likelihood of gastrointestinal cancers in men with anemia of unknown causes and at ages of 60 years living in schistosomiasis-endemic areas. SN - 1005-6661 UR - https://www.unboundmedicine.com/medline/citation/32458603/[Effect_of_schistosomiasis_japonica_on_the_development_of_gastric_and_colorectal_cancer]_ L2 - http://www.diseaseinfosearch.org/result/1746 DB - PRIME DP - Unbound Medicine ER -