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In vitro bactericidal activity of a carbohydrate polymer with zinc oxide for the treatment of chronic wounds.
J Med Microbiol. 2020 Jun; 69(6):874-880.JM

Abstract

Introduction.

Biological adhesives and effective topical therapeutic agents that improve wound healing are urgently required for the treatment of chronic ulcers. A biodegradable adhesive based on a carbohydrate polymer with zinc oxide (CPZO) was shown to possess anti-inflammatory activity and enhance wound healing, but its bactericidal activity was unknown.

Aim.

To investigate the bactericidal activity of CPZO against bacteria commonly present as infectious agents in chronic wounds.Methodology. We examined the bactericidal activity of CPZO against three biofilm-producing bacteria (Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) through three strategies: bacterial suspension, biofilm disruption and in vitro wound biofilm model.

Results.

In suspension cultures, CPZO had direct, potent bactericidal action against S. aureus within 24 h, whereas E. coli took 7 days to be eliminated. By contrast, P. aeruginosa survived up to 14 days with CPZO. CPZO had biofilm disruption activity against clinical isolates of S. aureus in the anti-biofilm test. Finally, in the in vitro wound biofilm model, CPZO dramatically reduced the bacterial viability of S. aureus and P. aeruginosa.

Conclusions.

Together with its previously shown anti-inflammatory properties, the bactericidal activity of CPZO gives it the potential to be a first-line therapeutic option for chronic various ulcers and, possibly, other chronic ulcers, preventing or controlling microbial infections, and leading to the healing of such complicated chronic ulcers.

Authors+Show Affiliations

Direction of Research, Hospital Juárez de México, Cuidad de México, Mexico.Direction of Research, Hospital Juárez de México, Cuidad de México, Mexico.Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.Health Sciences Faculty, Anahuac University, Estado de México, Mexico.Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.Health Sciences Faculty, Anahuac University, Estado de México, Mexico.Department of Microbiology, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico.Direction of Research, Hospital Juárez de México, Cuidad de México, Mexico.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32459619

Citation

Bello-López, Juan Manuel, et al. "In Vitro Bactericidal Activity of a Carbohydrate Polymer With Zinc Oxide for the Treatment of Chronic Wounds." Journal of Medical Microbiology, vol. 69, no. 6, 2020, pp. 874-880.
Bello-López JM, López-Ornelas A, Vilchis-Rangel RE, et al. In vitro bactericidal activity of a carbohydrate polymer with zinc oxide for the treatment of chronic wounds. J Med Microbiol. 2020;69(6):874-880.
Bello-López, J. M., López-Ornelas, A., Vilchis-Rangel, R. E., Ribas-Aparicio, R. M., Del-Moral, P., Donis-Rocandio, J. E., Cueto, J., Aparicio-Ozores, G., & Moreno, J. (2020). In vitro bactericidal activity of a carbohydrate polymer with zinc oxide for the treatment of chronic wounds. Journal of Medical Microbiology, 69(6), 874-880. https://doi.org/10.1099/jmm.0.001204
Bello-López JM, et al. In Vitro Bactericidal Activity of a Carbohydrate Polymer With Zinc Oxide for the Treatment of Chronic Wounds. J Med Microbiol. 2020;69(6):874-880. PubMed PMID: 32459619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro bactericidal activity of a carbohydrate polymer with zinc oxide for the treatment of chronic wounds. AU - Bello-López,Juan Manuel, AU - López-Ornelas,Adolfo, AU - Vilchis-Rangel,Rodolfo Erik, AU - Ribas-Aparicio,Rosa María, AU - Del-Moral,Pamela, AU - Donis-Rocandio,Jenny Elizabeth, AU - Cueto,Jorge, AU - Aparicio-Ozores,Gerardo, AU - Moreno,José, PY - 2020/5/28/pubmed PY - 2020/7/7/medline PY - 2020/5/28/entrez KW - Pebisut KW - bactericidal activity KW - carbohydrate polymer KW - chronic wounds KW - zinc oxide SP - 874 EP - 880 JF - Journal of medical microbiology JO - J. Med. Microbiol. VL - 69 IS - 6 N2 - Introduction. Biological adhesives and effective topical therapeutic agents that improve wound healing are urgently required for the treatment of chronic ulcers. A biodegradable adhesive based on a carbohydrate polymer with zinc oxide (CPZO) was shown to possess anti-inflammatory activity and enhance wound healing, but its bactericidal activity was unknown.Aim. To investigate the bactericidal activity of CPZO against bacteria commonly present as infectious agents in chronic wounds.Methodology. We examined the bactericidal activity of CPZO against three biofilm-producing bacteria (Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) through three strategies: bacterial suspension, biofilm disruption and in vitro wound biofilm model.Results. In suspension cultures, CPZO had direct, potent bactericidal action against S. aureus within 24 h, whereas E. coli took 7 days to be eliminated. By contrast, P. aeruginosa survived up to 14 days with CPZO. CPZO had biofilm disruption activity against clinical isolates of S. aureus in the anti-biofilm test. Finally, in the in vitro wound biofilm model, CPZO dramatically reduced the bacterial viability of S. aureus and P. aeruginosa.Conclusions. Together with its previously shown anti-inflammatory properties, the bactericidal activity of CPZO gives it the potential to be a first-line therapeutic option for chronic various ulcers and, possibly, other chronic ulcers, preventing or controlling microbial infections, and leading to the healing of such complicated chronic ulcers. SN - 1473-5644 UR - https://www.unboundmedicine.com/medline/citation/32459619/In_vitro_bactericidal_activity_of_a_carbohydrate_polymer_with_zinc_oxide_for_the_treatment_of_chronic_wounds L2 - http://jmm.microbiologyresearch.org/pubmed/content/journal/jmm/10.1099/jmm.0.001204 DB - PRIME DP - Unbound Medicine ER -