Tags

Type your tag names separated by a space and hit enter

The amount of cytokine-release defines different shades of Sars-Cov2 infection.
Exp Biol Med (Maywood). 2020 06; 245(11):970-976.EB

Abstract

The recent outbreak of coronavirus disease (COVID 19), spreading from China all around the world in early 2020, has led scientists to investigate the immuno-mediated mechanisms underlying the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection. Depending on the amount of cytokines released as the result of the immunological activation induced by SARS-CoV2, three major clinical phenotypes can be identified: "mild",symbolized as a "drizzle" of cytokines, severe as a "storm", and critical as a "hurricane". In patients with mild symptoms, the release of pro-inflammatory cytokines is balanced to obtain a defense response against the virus which is often self-limiting and overcomes without tissue damage. In severe phenotype, resembling a "cytokine-release syndrome", SARS-CoV2 causes the lysis of the immune-mediators leading to a cytokine storm able to induce lung epithelium damage and acute respiratory distress syndrome. In critical patients, the immune response may become uncontrolled, thus the cytokine burst resembles a form of secondary hemophagocytic lymphohistiocytosis which may result in a multi organ failure. In addition to the standard of care, an immune-modulatory therapy tailored to each one of the different phenotypes should be used in order to prevent or reduce the release of cytokines responsible for organ damage and disease progression.

Authors+Show Affiliations

Rheumatology Unit, Department of Medicine, University of Padova, Padova 35128, Italy.Rheumatology Unit, Department of Medicine, University of Padova, Padova 35128, Italy.Rheumatology Unit, Department of Medicine, University of Padova, Padova 35128, Italy.Rheumatology Unit, Department of Medicine, University of Padova, Padova 35128, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32460624

Citation

Bindoli, S, et al. "The Amount of Cytokine-release Defines Different Shades of Sars-Cov2 Infection." Experimental Biology and Medicine (Maywood, N.J.), vol. 245, no. 11, 2020, pp. 970-976.
Bindoli S, Felicetti M, Sfriso P, et al. The amount of cytokine-release defines different shades of Sars-Cov2 infection. Exp Biol Med (Maywood). 2020;245(11):970-976.
Bindoli, S., Felicetti, M., Sfriso, P., & Doria, A. (2020). The amount of cytokine-release defines different shades of Sars-Cov2 infection. Experimental Biology and Medicine (Maywood, N.J.), 245(11), 970-976. https://doi.org/10.1177/1535370220928964
Bindoli S, et al. The Amount of Cytokine-release Defines Different Shades of Sars-Cov2 Infection. Exp Biol Med (Maywood). 2020;245(11):970-976. PubMed PMID: 32460624.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The amount of cytokine-release defines different shades of Sars-Cov2 infection. AU - Bindoli,S, AU - Felicetti,M, AU - Sfriso,P, AU - Doria,A, Y1 - 2020/05/28/ PY - 2020/5/29/pubmed PY - 2020/7/14/medline PY - 2020/5/29/entrez KW - COVID-19 KW - CRS KW - HLH/MAS KW - SARS-CoV2 KW - cytokines SP - 970 EP - 976 JF - Experimental biology and medicine (Maywood, N.J.) JO - Exp Biol Med (Maywood) VL - 245 IS - 11 N2 - The recent outbreak of coronavirus disease (COVID 19), spreading from China all around the world in early 2020, has led scientists to investigate the immuno-mediated mechanisms underlying the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection. Depending on the amount of cytokines released as the result of the immunological activation induced by SARS-CoV2, three major clinical phenotypes can be identified: "mild",symbolized as a "drizzle" of cytokines, severe as a "storm", and critical as a "hurricane". In patients with mild symptoms, the release of pro-inflammatory cytokines is balanced to obtain a defense response against the virus which is often self-limiting and overcomes without tissue damage. In severe phenotype, resembling a "cytokine-release syndrome", SARS-CoV2 causes the lysis of the immune-mediators leading to a cytokine storm able to induce lung epithelium damage and acute respiratory distress syndrome. In critical patients, the immune response may become uncontrolled, thus the cytokine burst resembles a form of secondary hemophagocytic lymphohistiocytosis which may result in a multi organ failure. In addition to the standard of care, an immune-modulatory therapy tailored to each one of the different phenotypes should be used in order to prevent or reduce the release of cytokines responsible for organ damage and disease progression. SN - 1535-3699 UR - https://www.unboundmedicine.com/medline/citation/32460624/The_amount_of_cytokine_release_defines_different_shades_of_Sars_Cov2_infection_ L2 - https://journals.sagepub.com/doi/10.1177/1535370220928964?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -