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An isolated vaginal metastasis from intestinal signet ring cell carcinoma: a case report and literature review.
BMC Cancer. 2020 May 27; 20(1):478.BC

Abstract

BACKGROUND

Isolated vaginal metastases from intestinal signet ring cell carcinoma are extremely rare. There are no reported cases in the domestic or foreign literature. The characteristics of such cases of metastasis remain relatively unknown. As a life-threatening malignant tumor, it is very important to carry out a systemic tumor examination and transvaginal biopsy, even though clinical symptoms are not typical and there is no systemic tumor history.

CASE PRESENTATION

We present a case of an isolated vaginal metastasis from intestinal cancer in a 45-year-old female patient. The patient experienced a small amount of irregular vaginal bleeding and difficulty urinating. She had no history of systemic cancer. An early physical examination and transvaginal ultrasound (TVS) showed marked thickening of the entire vaginal wall. Pelvic nuclear magnetic resonance imaging (MRI) and a colposcopic biopsy were used to diagnose her with chronic vaginitis. An analysis of the vaginal wall biopsy showed signet ring cell carcinoma. Colorectal colonoscopy revealed advanced interstitial signet ring cell carcinoma as the primary source of vaginal wall infiltration. We review previous case reports of vaginal metastases from colorectal cancer and discuss the symptoms, pathological type, and outcomes.

CONCLUSIONS

We hypothesize that vaginal wall thickening and stiffness accompanied by chronic inflammatory-like changes may be clinical features of a vaginal metastasis of signet ring cell carcinoma of the intestine. We also emphasize that it is very important to perform a systemic tumor examination in a timely manner when a patient has the abovementioned symptoms.

Authors+Show Affiliations

The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. TiananJiang@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32460802

Citation

Zhu, Xiao Dan, et al. "An Isolated Vaginal Metastasis From Intestinal Signet Ring Cell Carcinoma: a Case Report and Literature Review." BMC Cancer, vol. 20, no. 1, 2020, p. 478.
Zhu XD, Wang J, You QH, et al. An isolated vaginal metastasis from intestinal signet ring cell carcinoma: a case report and literature review. BMC Cancer. 2020;20(1):478.
Zhu, X. D., Wang, J., You, Q. H., & Jiang, T. A. (2020). An isolated vaginal metastasis from intestinal signet ring cell carcinoma: a case report and literature review. BMC Cancer, 20(1), 478. https://doi.org/10.1186/s12885-020-06950-x
Zhu XD, et al. An Isolated Vaginal Metastasis From Intestinal Signet Ring Cell Carcinoma: a Case Report and Literature Review. BMC Cancer. 2020 May 27;20(1):478. PubMed PMID: 32460802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An isolated vaginal metastasis from intestinal signet ring cell carcinoma: a case report and literature review. AU - Zhu,Xiao Dan, AU - Wang,Jin, AU - You,Qin Han, AU - Jiang,Tian An, Y1 - 2020/05/27/ PY - 2019/08/23/received PY - 2020/05/11/accepted PY - 2020/5/29/entrez PY - 2020/5/29/pubmed PY - 2020/5/29/medline KW - Intestinal signet ring cell carcinoma KW - Ultrasound KW - Vaginal chronic inflammation KW - Vaginal metastasis SP - 478 EP - 478 JF - BMC cancer JO - BMC Cancer VL - 20 IS - 1 N2 - BACKGROUND: Isolated vaginal metastases from intestinal signet ring cell carcinoma are extremely rare. There are no reported cases in the domestic or foreign literature. The characteristics of such cases of metastasis remain relatively unknown. As a life-threatening malignant tumor, it is very important to carry out a systemic tumor examination and transvaginal biopsy, even though clinical symptoms are not typical and there is no systemic tumor history. CASE PRESENTATION: We present a case of an isolated vaginal metastasis from intestinal cancer in a 45-year-old female patient. The patient experienced a small amount of irregular vaginal bleeding and difficulty urinating. She had no history of systemic cancer. An early physical examination and transvaginal ultrasound (TVS) showed marked thickening of the entire vaginal wall. Pelvic nuclear magnetic resonance imaging (MRI) and a colposcopic biopsy were used to diagnose her with chronic vaginitis. An analysis of the vaginal wall biopsy showed signet ring cell carcinoma. Colorectal colonoscopy revealed advanced interstitial signet ring cell carcinoma as the primary source of vaginal wall infiltration. We review previous case reports of vaginal metastases from colorectal cancer and discuss the symptoms, pathological type, and outcomes. CONCLUSIONS: We hypothesize that vaginal wall thickening and stiffness accompanied by chronic inflammatory-like changes may be clinical features of a vaginal metastasis of signet ring cell carcinoma of the intestine. We also emphasize that it is very important to perform a systemic tumor examination in a timely manner when a patient has the abovementioned symptoms. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/32460802/An_isolated_vaginal_metastasis_from_intestinal_signet_ring_cell_carcinoma:_a_case_report_and_literature_review L2 - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-06950-x DB - PRIME DP - Unbound Medicine ER -
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