Tags

Type your tag names separated by a space and hit enter

The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries.
J Neurol Sci. 2020 07 15; 414:116884.JN

Abstract

A comprehensive review of the neurological disorders reported during the current COVID-19 pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system (CNS), the peripheral nervous system (PNS) and the muscle. CNS manifestations include: headache and decreased responsiveness considered initial indicators of potential neurological involvement; anosmia, hyposmia, hypogeusia, and dysgeusia are frequent early symptoms of coronavirus infection. Respiratory failure, the lethal manifestation of COVID-19, responsible for 264,679 deaths worldwide, is probably neurogenic in origin and may result from the viral invasion of cranial nerve I, progressing into rhinencephalon and brainstem respiratory centers. Cerebrovascular disease, in particular large-vessel ischemic strokes, and less frequently cerebral venous thrombosis, intracerebral hemorrhage and subarachnoid hemorrhage, usually occur as part of a thrombotic state induced by viral attachment to ACE2 receptors in endothelium causing widespread endotheliitis, coagulopathy, arterial and venous thromboses. Acute hemorrhagic necrotizing encephalopathy is associated to the cytokine storm. A frontal hypoperfusion syndrome has been identified. There are isolated reports of seizures, encephalopathy, meningitis, encephalitis, and myelitis. The neurological diseases affecting the PNS and muscle in COVID-19 are less frequent and include Guillain-Barré syndrome; Miller Fisher syndrome; polyneuritis cranialis; and rare instances of viral myopathy with rhabdomyolysis. The main conclusion of this review is the pressing need to define the neurology of COVID-19, its frequency, manifestations, neuropathology and pathogenesis. On behalf of the World Federation of Neurology we invite national and regional neurological associations to create local databases to report cases with neurological manifestations observed during the on-going pandemic. International neuroepidemiological collaboration may help define the natural history of this worldwide problem.

Authors+Show Affiliations

Environmental Neurology Specialty Group of the World Federation of Neurology (ENSG-WFN), London, UK; Department of Neurology, Neurological Institute, Houston Methodist Hospital, 6560 Fannin Street, Suite 802, Houston, TX 77030, USA. Electronic address: gcroman@houstonmethodist.org.Department of Neurology, School of Medicine, Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, USA.Université de Strasbourg, 67000 Strasbourg, France and Association RISE, 67205 Oberhausbergen, France.General (r) French Army Health Services, Malaria Research Unit, UMR 5246 CNRS, Claude-Bernard Lyon-1 University, 69622 Villeurbanne, France.World Congress of Neurology, Marrakesh WCN2011, Moroccan Foundation Against Neurological Disease, Neurology, Mohammed V University of Rabat, Rabat, Morocco.Neurology Department, Jaslok Hospital & Research Center, Professor Emeritus GMC and Sir JJ Group of Hospitals, Mumbai, India.Spanish Neurological Society, Department of Neurology, University Clinic Hospital, Catholic University of Valencia, 46010, Valencia, Spain.Latin America, WFN, Pan American Federation of Neurological Societies (PAFNS), Neurology and Epileptology, Faculty of Medical Sciences, National Autonomous University of Honduras, Tegucigalpa, Honduras.Indian Academy of Neurology. Nagpur, India.World Congress of Neurology, Kyoto WCN2017, National Center of Neurology and Psychiatry (NCNP), Japan, Department of Neurology and Neurological Science, Graduate School of Medical and Dental Sciences, Tokyo, Japan.Turkish Neurological Society, Department of Neurology, Selcuk University Faculty of Medicine, Konya, Turkey.Pakistan International Neuroscience Society, Neurology, Aga Khan University, Karachi, Pakistan.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32464367

Citation

Román, Gustavo C., et al. "The Neurology of COVID-19 Revisited: a Proposal From the Environmental Neurology Specialty Group of the World Federation of Neurology to Implement International Neurological Registries." Journal of the Neurological Sciences, vol. 414, 2020, p. 116884.
Román GC, Spencer PS, Reis J, et al. The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. J Neurol Sci. 2020;414:116884.
Román, G. C., Spencer, P. S., Reis, J., Buguet, A., Faris, M. E. A., Katrak, S. M., Láinez, M., Medina, M. T., Meshram, C., Mizusawa, H., Öztürk, S., & Wasay, M. (2020). The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. Journal of the Neurological Sciences, 414, 116884. https://doi.org/10.1016/j.jns.2020.116884
Román GC, et al. The Neurology of COVID-19 Revisited: a Proposal From the Environmental Neurology Specialty Group of the World Federation of Neurology to Implement International Neurological Registries. J Neurol Sci. 2020 07 15;414:116884. PubMed PMID: 32464367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neurology of COVID-19 revisited: A proposal from the Environmental Neurology Specialty Group of the World Federation of Neurology to implement international neurological registries. AU - Román,Gustavo C, AU - Spencer,Peter S, AU - Reis,Jacques, AU - Buguet,Alain, AU - Faris,Mostafa El Alaoui, AU - Katrak,Sarosh M, AU - Láinez,Miguel, AU - Medina,Marco Tulio, AU - Meshram,Chandrashekhar, AU - Mizusawa,Hidehiro, AU - Öztürk,Serefnur, AU - Wasay,Mohammad, AU - ,, Y1 - 2020/05/07/ PY - 2020/04/29/received PY - 2020/04/30/accepted PY - 2020/5/29/pubmed PY - 2020/7/1/medline PY - 2020/5/29/entrez KW - COVID-19 neurological complications KW - Coronavirus disease 2019 KW - Coronaviruses KW - Endotheliitis KW - Environmental neurology, MERS KW - MERS-CoV KW - Neuroepidemiology KW - Neuropathology KW - Pandemic KW - SARS KW - SARS-CoV-1 KW - SARS-CoV-2 KW - Viral neurotropism KW - Zoonosis SP - 116884 EP - 116884 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 414 N2 - A comprehensive review of the neurological disorders reported during the current COVID-19 pandemic demonstrates that infection with SARS-CoV-2 affects the central nervous system (CNS), the peripheral nervous system (PNS) and the muscle. CNS manifestations include: headache and decreased responsiveness considered initial indicators of potential neurological involvement; anosmia, hyposmia, hypogeusia, and dysgeusia are frequent early symptoms of coronavirus infection. Respiratory failure, the lethal manifestation of COVID-19, responsible for 264,679 deaths worldwide, is probably neurogenic in origin and may result from the viral invasion of cranial nerve I, progressing into rhinencephalon and brainstem respiratory centers. Cerebrovascular disease, in particular large-vessel ischemic strokes, and less frequently cerebral venous thrombosis, intracerebral hemorrhage and subarachnoid hemorrhage, usually occur as part of a thrombotic state induced by viral attachment to ACE2 receptors in endothelium causing widespread endotheliitis, coagulopathy, arterial and venous thromboses. Acute hemorrhagic necrotizing encephalopathy is associated to the cytokine storm. A frontal hypoperfusion syndrome has been identified. There are isolated reports of seizures, encephalopathy, meningitis, encephalitis, and myelitis. The neurological diseases affecting the PNS and muscle in COVID-19 are less frequent and include Guillain-Barré syndrome; Miller Fisher syndrome; polyneuritis cranialis; and rare instances of viral myopathy with rhabdomyolysis. The main conclusion of this review is the pressing need to define the neurology of COVID-19, its frequency, manifestations, neuropathology and pathogenesis. On behalf of the World Federation of Neurology we invite national and regional neurological associations to create local databases to report cases with neurological manifestations observed during the on-going pandemic. International neuroepidemiological collaboration may help define the natural history of this worldwide problem. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/32464367/The_neurology_of_COVID_19_revisited:_A_proposal_from_the_Environmental_Neurology_Specialty_Group_of_the_World_Federation_of_Neurology_to_implement_international_neurological_registries_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(20)30220-3 DB - PRIME DP - Unbound Medicine ER -