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Biocompatibility and Antimicrobial Activity of Reynoutria elliptica Extract for Dental Application.
Plants (Basel). 2020 May 26; 9(6)P

Abstract

This study was conducted to determine whether nature-derived Reynoutria elliptica extracts exhibit biocompatibility and antimicrobial effects against oral pathogens such as Streptococcus mutans and Candida albicans. Fine particles of Reynoutria elliptica extract were used to probe for biocompatibility and antimicrobial activity toward these pathogens, and results were evaluated with an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay, spectrophotometric growth inhibitory assay, the total number of colony-forming units (CFU), an agar disk diffusion test, and scanning electron microscopy (SEM). In addition, UV/VIS spectroscopy was used to determine the levels of flavonoid and polyphenol in experimental solutions. Several experimental groups showed cell viability higher than 70%, and the antimicrobial activity toward both S. mutans and C. albicans was significantly higher than was that seen for the control group. In CFU and agar disk diffusion tests with C. albicans, increases in the concentration of Reynoutria elliptica extract led to significantly increased antimicrobial effects. Additionally, SEM results showed that Reynoutria elliptica extract changed the morphology and density of S. mutans and C. albicans. The results of this research can be applied to the use of Reynoutria elliptica extracts for the development of oral products that are biologically friendly and can control oral diseases such as dental caries and candida-associated denture stomatitis.

Authors+Show Affiliations

Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul 03722, Korea.Department of Dental Hygiene, Hanseo University, Chungcheongnam-do 31962, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32466520

Citation

Yang, Song-Yi, and Min-Kyung Kang. "Biocompatibility and Antimicrobial Activity of Reynoutria Elliptica Extract for Dental Application." Plants (Basel, Switzerland), vol. 9, no. 6, 2020.
Yang SY, Kang MK. Biocompatibility and Antimicrobial Activity of Reynoutria elliptica Extract for Dental Application. Plants (Basel). 2020;9(6).
Yang, S. Y., & Kang, M. K. (2020). Biocompatibility and Antimicrobial Activity of Reynoutria elliptica Extract for Dental Application. Plants (Basel, Switzerland), 9(6). https://doi.org/10.3390/plants9060670
Yang SY, Kang MK. Biocompatibility and Antimicrobial Activity of Reynoutria Elliptica Extract for Dental Application. Plants (Basel). 2020 May 26;9(6) PubMed PMID: 32466520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biocompatibility and Antimicrobial Activity of Reynoutria elliptica Extract for Dental Application. AU - Yang,Song-Yi, AU - Kang,Min-Kyung, Y1 - 2020/05/26/ PY - 2020/05/11/received PY - 2020/05/22/revised PY - 2020/05/24/accepted PY - 2020/5/30/entrez PY - 2020/5/30/pubmed PY - 2020/5/30/medline KW - Candida albicans KW - Reynoutria elliptica extract KW - Streptococcus mutans KW - antibacterial KW - antifungal KW - cell viability KW - dental materials JF - Plants (Basel, Switzerland) JO - Plants (Basel) VL - 9 IS - 6 N2 - This study was conducted to determine whether nature-derived Reynoutria elliptica extracts exhibit biocompatibility and antimicrobial effects against oral pathogens such as Streptococcus mutans and Candida albicans. Fine particles of Reynoutria elliptica extract were used to probe for biocompatibility and antimicrobial activity toward these pathogens, and results were evaluated with an MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay, spectrophotometric growth inhibitory assay, the total number of colony-forming units (CFU), an agar disk diffusion test, and scanning electron microscopy (SEM). In addition, UV/VIS spectroscopy was used to determine the levels of flavonoid and polyphenol in experimental solutions. Several experimental groups showed cell viability higher than 70%, and the antimicrobial activity toward both S. mutans and C. albicans was significantly higher than was that seen for the control group. In CFU and agar disk diffusion tests with C. albicans, increases in the concentration of Reynoutria elliptica extract led to significantly increased antimicrobial effects. Additionally, SEM results showed that Reynoutria elliptica extract changed the morphology and density of S. mutans and C. albicans. The results of this research can be applied to the use of Reynoutria elliptica extracts for the development of oral products that are biologically friendly and can control oral diseases such as dental caries and candida-associated denture stomatitis. SN - 2223-7747 UR - https://www.unboundmedicine.com/medline/citation/32466520/Biocompatibility_and_Antimicrobial_Activity_of_Reynoutria_elliptica_Extract_for_Dental_Application L2 - https://www.mdpi.com/resolver?pii=plants9060670 DB - PRIME DP - Unbound Medicine ER -
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