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Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort.
Am J Gastroenterol. 2020 08; 115(8):1293-1297.AJ

Abstract

INTRODUCTION

This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake.

METHODS

NutriNet-Santé cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC.

RESULTS

Among the 105,832 participants, 27 reported incident CD and 48 reported incident UC. The relative risks of CD decreased with dietary zinc intakes. Compared with participants with the lowest tertile of zinc intake, the relative risks for CD were 0.60 (95% confidence interval [0.22-1.66]) and 0.12 (95% confidence interval [0.02-0.73]) for the second and the highest tertiles, respectively (Ptrend = 0.02). No significant association was observed for UC.

DISCUSSION

Dietary zinc intake was inversely associated with incident CD.

Authors+Show Affiliations

Equipe de Recherche en épidémiologie nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France. Département de santé publique, hôpital Avicenne (APHP), Bobigny, France.Service de Gastroentérologie et nutrition pédiatrique, Hôpital Robert Debré (APHP), Paris, France.Service de gastroentérologie, Hôpital Avicenne (APHP), Bobigny, France.Service de gastroentérologie, Hôpital Charles Nicolle, Rouen, France.Equipe de Recherche en épidémiologie nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France. Département de santé publique, hôpital Avicenne (APHP), Bobigny, France.Equipe de Recherche en épidémiologie nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France.Service de Gastroentérologie et nutrition pédiatrique, Hôpital Robert Debré (APHP), Paris, France. Centre de recherche sur l'inflammation, UMR1149 INSERM et Université de Paris, Paris, France.Equipe de Recherche en épidémiologie nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France. Département de santé publique, hôpital Avicenne (APHP), Bobigny, France.UMR PNCA, AgroParisTech, INRA, Université Paris-Saclay, Paris, France.Equipe de Recherche en épidémiologie nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France. Département de santé publique, hôpital Avicenne (APHP), Bobigny, France.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32467505

Citation

Vasseur, Pauline, et al. "Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort." The American Journal of Gastroenterology, vol. 115, no. 8, 2020, pp. 1293-1297.
Vasseur P, Dugelay E, Benamouzig R, et al. Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort. Am J Gastroenterol. 2020;115(8):1293-1297.
Vasseur, P., Dugelay, E., Benamouzig, R., Savoye, G., Hercberg, S., Touvier, M., Hugot, J. P., Julia, C., Lan, A., & Buscail, C. (2020). Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort. The American Journal of Gastroenterology, 115(8), 1293-1297. https://doi.org/10.14309/ajg.0000000000000688
Vasseur P, et al. Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort. Am J Gastroenterol. 2020;115(8):1293-1297. PubMed PMID: 32467505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort. AU - Vasseur,Pauline, AU - Dugelay,Emmanuelle, AU - Benamouzig,Robert, AU - Savoye,Guillaume, AU - Hercberg,Serge, AU - Touvier,Mathilde, AU - Hugot,Jean-Pierre, AU - Julia,Chantal, AU - Lan,Annaïg, AU - Buscail,Camille, PY - 2020/5/30/pubmed PY - 2020/9/29/medline PY - 2020/5/30/entrez SP - 1293 EP - 1297 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 115 IS - 8 N2 - INTRODUCTION: This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake. METHODS: NutriNet-Santé cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC. RESULTS: Among the 105,832 participants, 27 reported incident CD and 48 reported incident UC. The relative risks of CD decreased with dietary zinc intakes. Compared with participants with the lowest tertile of zinc intake, the relative risks for CD were 0.60 (95% confidence interval [0.22-1.66]) and 0.12 (95% confidence interval [0.02-0.73]) for the second and the highest tertiles, respectively (Ptrend = 0.02). No significant association was observed for UC. DISCUSSION: Dietary zinc intake was inversely associated with incident CD. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/32467505/Dietary_Zinc_Intake_and_Inflammatory_Bowel_Disease_in_the_French_NutriNet_Santé_Cohort_ L2 - https://Insights.ovid.com/pubmed?pmid=32467505 DB - PRIME DP - Unbound Medicine ER -