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Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19.
ACS Chem Neurosci. 2020 06 17; 11(12):1701-1703.AC

Abstract

The 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic disease that is dominated by pulmonary symptoms. However, recent reports of isolation of the virus from cerebrospinal fluid (CSF) coupled with radiological evidence of zones of necrosis in the brain, have elucidated the neurotropic potential of SARS-CoV-2. The acute respiratory failure seen in patients with COVID-19 is alarming and could be due to the effects of SARS-CoV-2 on the central respiratory regulatory centers in the brainstem. Appropriate interventions can be implemented to prevent severe outcomes of neurological invasion by SARS-CoV-2 to reduce the morbidity and mortality of patients with COVID-19. It is of paramount importance that the scientific community alerts the healthcare professionals of the pieces of evidence that can herald them on the covert neurological deficits in progress in COVID-19.

Authors+Show Affiliations

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.Mount Auburn Hospital, Boston Urogynecology Associates, Cambridge, Massachusetts 02138, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32469504

Citation

Baig, Abdul Mannan, and Erin C. Sanders. "Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19." ACS Chemical Neuroscience, vol. 11, no. 12, 2020, pp. 1701-1703.
Baig AM, Sanders EC. Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19. ACS Chem Neurosci. 2020;11(12):1701-1703.
Baig, A. M., & Sanders, E. C. (2020). Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19. ACS Chemical Neuroscience, 11(12), 1701-1703. https://doi.org/10.1021/acschemneuro.0c00286
Baig AM, Sanders EC. Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19. ACS Chem Neurosci. 2020 06 17;11(12):1701-1703. PubMed PMID: 32469504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19. AU - Baig,Abdul Mannan, AU - Sanders,Erin C, Y1 - 2020/05/29/ PY - 2020/5/30/pubmed PY - 2020/6/27/medline PY - 2020/5/30/entrez KW - ACE2 KW - COVID-19 KW - SARS-CoV-2 KW - anosmia KW - healthcare in COVID-19 KW - neurovirulence SARS-CoV-2 SP - 1701 EP - 1703 JF - ACS chemical neuroscience JO - ACS Chem Neurosci VL - 11 IS - 12 N2 - The 2019 novel coronavirus disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a zoonotic disease that is dominated by pulmonary symptoms. However, recent reports of isolation of the virus from cerebrospinal fluid (CSF) coupled with radiological evidence of zones of necrosis in the brain, have elucidated the neurotropic potential of SARS-CoV-2. The acute respiratory failure seen in patients with COVID-19 is alarming and could be due to the effects of SARS-CoV-2 on the central respiratory regulatory centers in the brainstem. Appropriate interventions can be implemented to prevent severe outcomes of neurological invasion by SARS-CoV-2 to reduce the morbidity and mortality of patients with COVID-19. It is of paramount importance that the scientific community alerts the healthcare professionals of the pieces of evidence that can herald them on the covert neurological deficits in progress in COVID-19. SN - 1948-7193 UR - https://www.unboundmedicine.com/medline/citation/32469504/Heralding_Healthcare_Professionals:_Recognition_of_Neurological_Deficits_in_COVID_19_ L2 - https://doi.org/10.1021/acschemneuro.0c00286 DB - PRIME DP - Unbound Medicine ER -