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Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USA.
Emerg Infect Dis. 2020 Aug; 26(8):1671-1678.EI

Abstract

We describe the contact investigation for an early confirmed case of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the United States. Contacts of the case-patient were identified, actively monitored for symptoms, interviewed for a detailed exposure history, and tested for SARS-CoV-2 infection by real-time reverse transcription PCR (rRT-PCR) and ELISA. Fifty contacts were identified and 38 (76%) were interviewed, of whom 11 (29%) reported unprotected face-to-face interaction with the case-patient. Thirty-seven (74%) had respiratory specimens tested by rRT-PCR, and all tested negative. Twenty-three (46%) had ELISA performed on serum samples collected ≈6 weeks after exposure, and none had detectable antibodies to SARS-CoV-2. Among contacts who were tested, no secondary transmission was identified in this investigation, despite unprotected close interactions with the infectious case-patient.

Authors

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Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

32470316

Citation

Chu, Victoria T., et al. "Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient With COVID-19, Washington, USA." Emerging Infectious Diseases, vol. 26, no. 8, 2020, pp. 1671-1678.
Chu VT, Freeman-Ponder B, Lindquist S, et al. Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USA. Emerg Infect Dis. 2020;26(8):1671-1678.
Chu, V. T., Freeman-Ponder, B., Lindquist, S., Spitters, C., Kawakami, V., Dyal, J. W., Clark, S., Bruce, H., Duchin, J. S., DeBolt, C., Podczervinski, S., D'Angeli, M., Pettrone, K., Zacks, R., Vahey, G., Holshue, M. L., Lang, M., Burke, R. M., Rolfes, M. A., ... Biggs, H. M. (2020). Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USA. Emerging Infectious Diseases, 26(8), 1671-1678. https://doi.org/10.3201/eid2608.201423
Chu VT, et al. Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient With COVID-19, Washington, USA. Emerg Infect Dis. 2020;26(8):1671-1678. PubMed PMID: 32470316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USA. AU - Chu,Victoria T, AU - Freeman-Ponder,Brandi, AU - Lindquist,Scott, AU - Spitters,Christopher, AU - Kawakami,Vance, AU - Dyal,Jonathan W, AU - Clark,Shauna, AU - Bruce,Hollianne, AU - Duchin,Jeffrey S, AU - DeBolt,Chas, AU - Podczervinski,Sara, AU - D'Angeli,Marisa, AU - Pettrone,Kristen, AU - Zacks,Rachael, AU - Vahey,Grace, AU - Holshue,Michelle L, AU - Lang,Misty, AU - Burke,Rachel M, AU - Rolfes,Melissa A, AU - Marlow,Mariel, AU - Midgley,Claire M, AU - Lu,Xiaoyan, AU - Lindstrom,Stephen, AU - Hall,Aron J, AU - Fry,Alicia M, AU - Thornburg,Natalie J, AU - Gerber,Susan I, AU - Pillai,Satish K, AU - Biggs,Holly M, Y1 - 2020/05/29/ PY - 2020/5/30/pubmed PY - 2020/7/30/medline PY - 2020/5/30/entrez KW - 2019 novel coronavirus disease KW - COVID-19 KW - SARS-CoV-2 KW - contact tracing KW - coronavirus KW - coronavirus disease KW - respiratory infections KW - serology KW - severe acute respiratory syndrome coronavirus 2 KW - viruses KW - zoonoses SP - 1671 EP - 1678 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 26 IS - 8 N2 - We describe the contact investigation for an early confirmed case of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the United States. Contacts of the case-patient were identified, actively monitored for symptoms, interviewed for a detailed exposure history, and tested for SARS-CoV-2 infection by real-time reverse transcription PCR (rRT-PCR) and ELISA. Fifty contacts were identified and 38 (76%) were interviewed, of whom 11 (29%) reported unprotected face-to-face interaction with the case-patient. Thirty-seven (74%) had respiratory specimens tested by rRT-PCR, and all tested negative. Twenty-three (46%) had ELISA performed on serum samples collected ≈6 weeks after exposure, and none had detectable antibodies to SARS-CoV-2. Among contacts who were tested, no secondary transmission was identified in this investigation, despite unprotected close interactions with the infectious case-patient. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/32470316/Investigation_and_Serologic_Follow_Up_of_Contacts_of_an_Early_Confirmed_Case_Patient_with_COVID_19_Washington_USA_ L2 - https://doi.org/10.3201/eid2608.201423 DB - PRIME DP - Unbound Medicine ER -