Tags

Type your tag names separated by a space and hit enter

Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis-a compositional magnetic resonance imaging study.
Arthritis Res Ther. 2020 05 29; 22(1):124.AR

Abstract

BACKGROUND

Even though cartilage loss is a known feature of psoriatic arthritis (PsA), little is known about its role in the pathogenesis of PsA. Using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) as a non-invasive marker of the tissue's proteoglycan content, such early (i.e., pre-morphological) changes have been associated with inflammation in rheumatoid arthritis (RA). Yet, this association has not been studied before in PsA.

METHODS

The metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints of 17 patients with active PsA were evaluated by high-resolution clinical standard morphological and dGEMRIC sequences using a 3T MRI scanner (Magnetom Skyra, Siemens) and a dedicated 16-channel hand coil. Images were analyzed by two independent raters for dGEMRIC indices, PsA MRI scores (PsAMRIS), and total cartilage thickness (TCT). Kendall tau correlation coefficients (τ) were calculated.

RESULTS

We found significant negative correlations between dGEMRIC indices and total PsAMRIS (τ = - 0.5, p = 0.012), synovitis (τ = - 0.56, p = 0.006), flexor tenosynovitis (τ = - 0.4, p = 0.049), and periarticular inflammation (τ = - 0.72, p < 0.001). Significant positive correlations were found between TCT and dGEMRIC indices at all joint levels (τ = 0.43, p < 0.001). No significant correlations were determined between dGEMRIC indices and bone erosion, bone edema, or bone proliferation.

CONCLUSION

In PsA, proteoglycan loss as assessed by dGEMRIC is associated with periarticular inflammation, synovitis, and flexor tenosynovitis, but not with bone erosion or proliferation. Thereby, these findings contribute to in vivo concepts of the disease's pathophysiology. Beyond morphology, advanced MRI techniques may be used to assess cartilage composition in PsA and to identify early changes in the cartilage as an imaging biomarker with potential application in detection, monitoring, and prediction of outcomes of PsA.

TRIAL REGISTRATION

2014123117, December 2014.

Authors+Show Affiliations

University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany. danielbenjamin.abrar@med.uni-duesseldorf.de.University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany.University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany.University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany.University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany.University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany.University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225, Düsseldorf, Germany.Department and Hiller Research Unit for Rheumatology, UKD, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.Department and Hiller Research Unit for Rheumatology, UKD, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.Department and Hiller Research Unit for Rheumatology, UKD, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.Department and Hiller Research Unit for Rheumatology, UKD, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.Department and Hiller Research Unit for Rheumatology, UKD, Heinrich Heine University Düsseldorf, Moorenstrasse 5, 40225, Düsseldorf, Germany.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32471515

Citation

Abrar, Daniel B., et al. "Proteoglycan Loss in the Articular Cartilage Is Associated With Severity of Joint Inflammation in Psoriatic Arthritis-a Compositional Magnetic Resonance Imaging Study." Arthritis Research & Therapy, vol. 22, no. 1, 2020, p. 124.
Abrar DB, Schleich C, Nebelung S, et al. Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis-a compositional magnetic resonance imaging study. Arthritis Res Ther. 2020;22(1):124.
Abrar, D. B., Schleich, C., Nebelung, S., Frenken, M., Ullrich, T., Radke, K. L., Antoch, G., Vordenbäumen, S., Brinks, R., Schneider, M., Ostendorf, B., & Sewerin, P. (2020). Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis-a compositional magnetic resonance imaging study. Arthritis Research & Therapy, 22(1), 124. https://doi.org/10.1186/s13075-020-02219-7
Abrar DB, et al. Proteoglycan Loss in the Articular Cartilage Is Associated With Severity of Joint Inflammation in Psoriatic Arthritis-a Compositional Magnetic Resonance Imaging Study. Arthritis Res Ther. 2020 05 29;22(1):124. PubMed PMID: 32471515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proteoglycan loss in the articular cartilage is associated with severity of joint inflammation in psoriatic arthritis-a compositional magnetic resonance imaging study. AU - Abrar,Daniel B, AU - Schleich,Christoph, AU - Nebelung,Sven, AU - Frenken,Miriam, AU - Ullrich,Tim, AU - Radke,Karl Ludger, AU - Antoch,Gerald, AU - Vordenbäumen,Stefan, AU - Brinks,Ralph, AU - Schneider,Matthias, AU - Ostendorf,Benedikt, AU - Sewerin,Philipp, Y1 - 2020/05/29/ PY - 2020/02/07/received PY - 2020/05/14/accepted PY - 2020/5/31/entrez PY - 2020/5/31/pubmed PY - 2020/5/31/medline KW - Arthritis KW - Cartilage KW - Compositional imaging KW - Magnetic resonance imaging KW - Perfusion KW - PsAMRIS KW - Psoriatic arthritis KW - dGEMRIC SP - 124 EP - 124 JF - Arthritis research & therapy JO - Arthritis Res. Ther. VL - 22 IS - 1 N2 - BACKGROUND: Even though cartilage loss is a known feature of psoriatic arthritis (PsA), little is known about its role in the pathogenesis of PsA. Using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) as a non-invasive marker of the tissue's proteoglycan content, such early (i.e., pre-morphological) changes have been associated with inflammation in rheumatoid arthritis (RA). Yet, this association has not been studied before in PsA. METHODS: The metacarpophalangeal (MCP), proximal interphalangeal (PIP), and distal interphalangeal (DIP) joints of 17 patients with active PsA were evaluated by high-resolution clinical standard morphological and dGEMRIC sequences using a 3T MRI scanner (Magnetom Skyra, Siemens) and a dedicated 16-channel hand coil. Images were analyzed by two independent raters for dGEMRIC indices, PsA MRI scores (PsAMRIS), and total cartilage thickness (TCT). Kendall tau correlation coefficients (τ) were calculated. RESULTS: We found significant negative correlations between dGEMRIC indices and total PsAMRIS (τ = - 0.5, p = 0.012), synovitis (τ = - 0.56, p = 0.006), flexor tenosynovitis (τ = - 0.4, p = 0.049), and periarticular inflammation (τ = - 0.72, p < 0.001). Significant positive correlations were found between TCT and dGEMRIC indices at all joint levels (τ = 0.43, p < 0.001). No significant correlations were determined between dGEMRIC indices and bone erosion, bone edema, or bone proliferation. CONCLUSION: In PsA, proteoglycan loss as assessed by dGEMRIC is associated with periarticular inflammation, synovitis, and flexor tenosynovitis, but not with bone erosion or proliferation. Thereby, these findings contribute to in vivo concepts of the disease's pathophysiology. Beyond morphology, advanced MRI techniques may be used to assess cartilage composition in PsA and to identify early changes in the cartilage as an imaging biomarker with potential application in detection, monitoring, and prediction of outcomes of PsA. TRIAL REGISTRATION: 2014123117, December 2014. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/32471515/Proteoglycan_loss_in_the_articular_cartilage_is_associated_with_severity_of_joint_inflammation_in_psoriatic_arthritis-a_compositional_magnetic_resonance_imaging_study L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-020-02219-7 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.