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Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients.
Nat Commun. 2020 05 29; 11(1):2800.NC

Abstract

Understanding the particle size distribution in the air and patterns of environmental contamination of SARS-CoV-2 is essential for infection prevention policies. Here we screen surface and air samples from hospital rooms of COVID-19 patients for SARS-CoV-2 RNA. Environmental sampling is conducted in three airborne infection isolation rooms (AIIRs) in the ICU and 27 AIIRs in the general ward. 245 surface samples are collected. 56.7% of rooms have at least one environmental surface contaminated. High touch surface contamination is shown in ten (66.7%) out of 15 patients in the first week of illness, and three (20%) beyond the first week of illness (p = 0.01, χ2 test). Air sampling is performed in three of the 27 AIIRs in the general ward, and detects SARS-CoV-2 PCR-positive particles of sizes >4 µm and 1-4 µm in two rooms, despite these rooms having 12 air changes per hour. This warrants further study of the airborne transmission potential of SARS-CoV-2.

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Authors+Show Affiliations

Chia PY
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Coleman KK
Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
Tan YK
DSO National Laboratories, Singapore, Singapore.
Ong SWX
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore.
Gum M
DSO National Laboratories, Singapore, Singapore.
Lau SK
DSO National Laboratories, Singapore, Singapore.
Lim XF
DSO National Laboratories, Singapore, Singapore.
Lim AS
DSO National Laboratories, Singapore, Singapore.
Sutjipto S
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore.
Lee PH
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore.
Son TT
Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
Young BE
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Milton DK
Maryland Institute for Applied Environmental Health, University of Maryland School of Public Health, College Park, MD, USA.
Gray GC
Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. School of Medicine and Global Health Institute, Duke University, Durham, NC, USA. Global Health Research Center, Duke Kunshan University, Kunshan, China.
Schuster S
Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, Singapore.
Barkham T
Tan Tock Seng Hospital, Singapore, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
De PP
Tan Tock Seng Hospital, Singapore, Singapore. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Vasoo S
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Chan M
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore.
Ang BSP
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Tan BH
DSO National Laboratories, Singapore, Singapore.
Leo YS
National Centre for Infectious Diseases, Singapore, Singapore. Tan Tock Seng Hospital, Singapore, Singapore. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ng OT
National Centre for Infectious Diseases, Singapore, Singapore. Oon_Tek_Ng@ncid.sg. Tan Tock Seng Hospital, Singapore, Singapore. Oon_Tek_Ng@ncid.sg. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Oon_Tek_Ng@ncid.sg.
Wong MSY
DSO National Laboratories, Singapore, Singapore.
Marimuthu K
National Centre for Infectious Diseases, Singapore, Singapore. kalisvar_marimuthu@ncid.sg. Tan Tock Seng Hospital, Singapore, Singapore. kalisvar_marimuthu@ncid.sg. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. kalisvar_marimuthu@ncid.sg.
Singapore 2019 Novel Coronavirus Outbreak Research Team
No affiliation info available

MeSH

AdultBetacoronavirusCOVID-19Coronavirus InfectionsCross-Sectional StudiesEnvironmental MicrobiologyFemaleHospitalsHumansMaleMiddle AgedPandemicsParticle SizeParticulate MatterPatients' RoomsPneumonia, ViralSARS-CoV-2Time Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32472043

Citation

Chia, Po Ying, et al. "Detection of Air and Surface Contamination By SARS-CoV-2 in Hospital Rooms of Infected Patients." Nature Communications, vol. 11, no. 1, 2020, p. 2800.
Chia PY, Coleman KK, Tan YK, et al. Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients. Nat Commun. 2020;11(1):2800.
Chia, P. Y., Coleman, K. K., Tan, Y. K., Ong, S. W. X., Gum, M., Lau, S. K., Lim, X. F., Lim, A. S., Sutjipto, S., Lee, P. H., Son, T. T., Young, B. E., Milton, D. K., Gray, G. C., Schuster, S., Barkham, T., De, P. P., Vasoo, S., Chan, M., ... Marimuthu, K. (2020). Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients. Nature Communications, 11(1), 2800. https://doi.org/10.1038/s41467-020-16670-2
Chia PY, et al. Detection of Air and Surface Contamination By SARS-CoV-2 in Hospital Rooms of Infected Patients. Nat Commun. 2020 05 29;11(1):2800. PubMed PMID: 32472043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of air and surface contamination by SARS-CoV-2 in hospital rooms of infected patients. AU - Chia,Po Ying, AU - Coleman,Kristen Kelli, AU - Tan,Yian Kim, AU - Ong,Sean Wei Xiang, AU - Gum,Marcus, AU - Lau,Sok Kiang, AU - Lim,Xiao Fang, AU - Lim,Ai Sim, AU - Sutjipto,Stephanie, AU - Lee,Pei Hua, AU - Son,Than The, AU - Young,Barnaby Edward, AU - Milton,Donald K, AU - Gray,Gregory C, AU - Schuster,Stephan, AU - Barkham,Timothy, AU - De,Partha Pratim, AU - Vasoo,Shawn, AU - Chan,Monica, AU - Ang,Brenda Sze Peng, AU - Tan,Boon Huan, AU - Leo,Yee-Sin, AU - Ng,Oon-Tek, AU - Wong,Michelle Su Yen, AU - Marimuthu,Kalisvar, AU - ,, Y1 - 2020/05/29/ PY - 2020/04/07/received PY - 2020/05/18/accepted PY - 2020/5/31/entrez PY - 2020/5/31/pubmed PY - 2020/6/17/medline SP - 2800 EP - 2800 JF - Nature communications JO - Nat Commun VL - 11 IS - 1 N2 - Understanding the particle size distribution in the air and patterns of environmental contamination of SARS-CoV-2 is essential for infection prevention policies. Here we screen surface and air samples from hospital rooms of COVID-19 patients for SARS-CoV-2 RNA. Environmental sampling is conducted in three airborne infection isolation rooms (AIIRs) in the ICU and 27 AIIRs in the general ward. 245 surface samples are collected. 56.7% of rooms have at least one environmental surface contaminated. High touch surface contamination is shown in ten (66.7%) out of 15 patients in the first week of illness, and three (20%) beyond the first week of illness (p = 0.01, χ2 test). Air sampling is performed in three of the 27 AIIRs in the general ward, and detects SARS-CoV-2 PCR-positive particles of sizes >4 µm and 1-4 µm in two rooms, despite these rooms having 12 air changes per hour. This warrants further study of the airborne transmission potential of SARS-CoV-2. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/32472043/full_citation L2 - https://doi.org/10.1038/s41467-020-16670-2 DB - PRIME DP - Unbound Medicine ER -